2019 American Transplant Congress
The Effects of Chronic Kidney Disease on Antiviral T Cell Response
*Purpose: Accumulation of memory T cells bearing markers of sustained antigen stimulation have been described in patients with chronic kidney disease (CKD). Cytomegalovirus (CMV) establishes…2019 American Transplant Congress
Circulating Exosomes with Cardiac Self-Antigens (Cardiac Myosin and Vimentin) and De Novo Development of Antibodies to Cardiac Self-Antigens Precedes Chronic Cardiac Allograft Rejection
Norton Thoracic Institute, St. Joseph’s Hospital and Medical Center, Phoenix, AZ
*Purpose: The aim of the study is to determine the kinetics of induction of circulating exosomes with cardiac self-antigens (SAgs), cardiac myosin (MYO) and Vimentin…2019 American Transplant Congress
FK506 Influence Glucose Metabolism by Short Chain Fatty Acid
*Purpose: FK506 is one of the most common immunosuppressant drugs in organ transplantation, which have been demonstrated to cause glucose metabolism disorder and alterd the…2019 American Transplant Congress
Changes in Kidney Offer Acceptance for Pediatric Candidates Post-KAS
Johns Hopkins University, Baltimore, MD
*Purpose:Stakeholders have expressed concerns regarding kidney transplant rates for pediatric candidates under KAS. To better understand what might be driving potential declines in access, we…2019 American Transplant Congress
Anti-HLA IgM Antibodies Are Reduced in Highly-HLA Sensitized Patients Transplanted after Imlifidase (IdeS) Treatment
*Purpose: Immunoglobulin-degrading enzyme from Streptococcus pyogenes (IdeS, Imlifidase) has been used to reduce antibody levels to promote transplant of highly sensitized patients. In vitro experiments…2019 American Transplant Congress
Molecular Analysis of Rejection and Injury in Human Liver Transplant Biopsies: First Results of the INTERLIVER Study
University of Alberta, Edmonton AB, AB, Canada
*Purpose: The relationship of histologic liver transplant biopsy assessments to actual rejection and injury is unclear. Recent progress in molecular reclassification of kidney, heart, and…2019 American Transplant Congress
MHC Molecule-Ablated Human Endothelial Cells Form Alloimmune-Evasive Microvessels
*Purpose: “Off the shelf” tissue-engineered organs will require use of allogeneic cell sources. Allogeneic human endothelial cells (ECs), necessary for organ perfusion, can initiate graft…2019 American Transplant Congress
Senescent Cell Clearance with Senolytic Drugs Improves Cardiac Allograft Survival by Targeting mt-DNA Mediated Immune Responses
*Purpose: Older organs represent an underutilized potential. We dissected alloimmune responses when transplanting older organs and tested if the depletion of senescent cells in older…2019 American Transplant Congress
More Than Meets the Eye: The Use of Serial Intravascular Ultrasound for Assessment of Cardiac Allograft Vasculopathy after Heart Transplantation
1Stanford University, Palo Alto, CA, 2University of Toronto, Toronto, ON, Canada
*Purpose: Cardiac allograft vasculopathy (CAV) is the “Achilles heel” of long-term survival after heart transplantation. While conventional coronary angiography is recognised as the standard for…2019 American Transplant Congress
Prevention of Ischemia Reperfusion Injury (IRI) & ABMR in HLA Sensitized Patients Treated with C1 Esterase Inhibitor (C1INH): Long-Term Follow Up
Cedars Sinai Medical Ctr, Los Angeles, CA
*Purpose: Delayed graft function (DGF) after kidney transplantation is a consequence of IRI/DGF. IRI/DGF requires intense medical management, is costly and predisposes to risk for…
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