2018 American Transplant Congress
Determining the Relative Immunogenicity of HLA Mismatches with Calcineurin Inhibitor Immunosuppression: An Analysis of the BENEFIT and BENEFIT-EXT Renal Transplant Cohort
We studied the relative immunogenicity of HLA-A, -B, -C, -DR and -DQ MM (serological) in a cohort of 291 kidney transplant patients from the BENEFIT…2018 American Transplant Congress
Urinary Tract Infections after Renal Transplantation: Is Male Gender a Risk Factor for Resistant Microorganisms?
Nephrology, Marmara University, School of Medicine, Istanbul, Turkey.
Introduction: Renal transplantation is the most effective treatment method for patients with the end-stage renal disease. The most common infections among these patients are urinary…2018 American Transplant Congress
Ischemia Reperfusion Injury in Liver Transplantation is Associated with Acute Kidney Injury: Role of Inflammatory Mediators
1Surgery, Indiana University, Indianapolis; 2Surgery, University of Pavia, Pavia, Italy.
Background: The impact of liver allograft ischemia/reperfusion injury (IRI) on native renal function remains to be characterized. We hypothesized that elevated levels of circulating inflammatory…2018 American Transplant Congress
Screening of RhoA/ROCK Inhibitors for the Ability to Prevent Chronic Rejection of Mouse Cardiac Allografts
Objectives. Chronic rejection of transplanted organs is a major obstacle in human organ transplantation. Although the mechanisms of chronic rejection are poorly understood it is…2018 American Transplant Congress
Ex Vivo Expanded Regulatory B Cells Promote Allograft Survival through IL-10-Dependent Pathway
Massachusetts General Hospital, Boston.
Immunomodulatory capacity of B cells make them a promising therapeutic tool for autoimmune and alloimmune response in patients. We found that transplant tolerance induced by…2018 American Transplant Congress
Recombinant Relaxin Protects Liver Transplants from Ischemia-Reperfusion Damage via Hepatocyte Glucocorticoid Receptor: From Bench-to-Bedside
Hepatic ischemia-reperfusion injury (IRI) represents a major risk factor of early graft dysfunction and acute/chronic rejection as well as a key obstacle to expanding the…2018 American Transplant Congress
Decreased Long-Term Survival with Antithymocyte Globulin Induction in Elderly Kidney Transplant Recipients
Henry Ford Transplant Institute, Detroit, MI.
Purpose: Long-term consequences of immunosuppression on the elderly is still unclear. This data to evaluates long-term outcomes for younger (Y) versus elderly (E) kidney transplant…2018 American Transplant Congress
Non-Medical Factors Predict Receipt and Type of Kidney Transplant in Veterans
VA Kidney Transplant Centers: IA, OR, PA, TN, Iowa City, Portland, Pittsburgh, Nashville.
Background: African Americans, Hispanic Americans and other minorities have a higher incidence of end-stage kidney disease but lower rates of both deceased and living donor…2018 American Transplant Congress
Outcomes of Pregnancies in Female Liver Transplant Recipients
The purpose of this study is to describe 544 pregnancies in 278 liver transplant recipients reporting to the Transplant Pregnancy Registry International (TPR) from 1991…2018 American Transplant Congress
Enrichment of Endogenous Donor-Reactive Tregs in the Spleen and Graft during Transplantation Tolerance is the Result of Treg Proliferation and Conversion from Tconv
Surgery and Medicine, University of Chicago, Chicago, IL.
Foxp3+ regulatory T cells (Tregs) are critical mediators of immune tolerance and are absolutely required for allograft tolerance in animal models. In addition, clinical trials…
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