2018 American Transplant Congress
Donor-Derived Cell-Free DNA Identifies Antibody-Mediated Rejection with Graft Injury in DSA-Positive Kidney Transplant Recipients
Purpose: Donor-derived cell-free DNA (dd-cfDNA) discriminates active rejection in kidney transplant patients. Donor-specific antibodies (DSA) to HLA antigens are associated with risk of antibody-mediated rejection…2018 American Transplant Congress
Introduction of Direct Acting Antivirals for HCV: Fewer Kidney Discards but a Long Way to Go
Organ shortage remains a great challenge facing the field of kidney transplantation. Donor hepatitis C virus positivity (DHCV+) is one of the highest ranking factors…2018 American Transplant Congress
Epitope/Eplet Mismatch in Pediatric Renal Transplantation and Development of Donor Specific Antibody
Background: De-novo donor specific antibody (DSA) is one of the strongest independent predictors of graft loss with HLA mismatching being a major risk factor for…2018 American Transplant Congress
Evolving Trends in Demographic and Medical Characteristics of Liver Transplant Recipients
IntroductionThe characteristics of liver transplant (LT) recipients have evolved over time as centers adapt to allocation policy changes and the shifting demographics of the US…2018 American Transplant Congress
Comparison of Induction and Maintenance Immunosuppression Regimens in Intestinal and Multivisceral Transplantation: An Analysis of the UNOS Registry
Aim: Induction and maintenance immunosuppression regimens in intestinal transplant widely vary among centers. The aim of this study was to investigate an association between immunosuppression…2018 American Transplant Congress
Multicentre Epidemiological Study on Prevalence of Recurrent Glomerular Disease Post-Transplantation in the United Kingdom
Introduction: Primary glomerulonephritidies (GN) can recur in the renal allograft and are possibly associated with poorer allograft outcome. The prevalence of recurrence varies widely and…2018 American Transplant Congress
Belatacept Maintenance Immunosuppression Use and Outcomes in the Real-World Clinical Setting Using OPTN/UNOS Kidney Transplant Registry
1Duke University Medical Center, Durham, NC; 2CTI Consulting, Raleigh, NC.
Introduction:Belatacept (BEL) was FDA approved for Kidney Transplantation (KTx) June 2011. It has largely been evaluated in two controlled trials (N Engl J Med 2016;374:333-43).…2018 American Transplant Congress
Aggressive Immunosuppression Minimization Shortens BK Viremia, Does Not Improve Outcome, but Increases the Risk of De Novo Donor Specific Antibodies in Kidney Recipients
Background: Immunosuppression (IS) minimization is the gold-standard treatment of BK virus (BKV) viremia in kidney transplant recipients (KTRs). However, the optimal approach to IS reduction…2018 American Transplant Congress
Discard and Post-Transplant Outcomes Associated with Organs Donated after Drug-Overdose Death
The United States faces an overdose epidemic primarily affecting young adults who might represent a novel source of viable deceased-donor organs. Utilization and outcomes associated…2018 American Transplant Congress
The Utility of a CD31/CD68 Dual Immunohistochemical Stain to Improve Accurate Diagnosis of Antibody Mediated Rejection in Cardiac Transplantation
Thoracic Pathology, University of Texas Southwestern Medical Center, Dallas, TX.
Antibody mediated rejection (AMR) occurs in 10%-20% of cardiac transplant patients and is associated with increased mortality. The endomyocardial biopsy, used to identify microvascular injury…
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