ATC Abstracts

American Transplant Congress abstracts

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  • 2018 American Transplant Congress

    False-Positive Flow-Cytometric T Cell Crossmatch Associated with Blood Type Antigen Expressed on Lymphocytes in ABO Incompatible Kidney Transplantation

    D. Iwami,1 M. Ito,2 K. Hotta,1 H. Higuchi,1 N. Shinohara.1

    1Renal and Genitourinary Surgery, Hokkaido University, Graduate School of Medicine, Sapporo, Japan; 2Division of Laboratory and Transfusion Medicine, Hokkaido University Hospital, Sapporo, Japan.

    Background: Flow-cytometric T cell crossmatch (FTXM) uses live donor lymphocytes to detect anti-donor-human leukocyte antigen (HLA) IgG antibodies. Therefore, the results can be affected by…
  • 2018 American Transplant Congress

    In Vivo and In Vitro PPAR-y Activation Decreases M1-Macrophage Polarization and Improves Liver Ischemia Reperfusion Injury

    I. Linares,1 A. Bartczak,1 K. Farrokhi,1 D. Kollmann,1 M. Kaths,1 M. Hamar,1 P. Urbanellis,1 S. Ganesh,1 O. Adeyi,2 P. Yip,3 M. Selzner,1 N. Selzner.1

    1Multi Organ Transplant Program, Toronto General Hospital, Toronto, ON, Canada; 2Department of Pathology, Toronto General Hospital, Toronto, ON, Canada; 3Laboratory of Medicine and Pathobiology, Toronto General Hospital, Toronto, ON, Canada.

    Background:M1-Macrophage polarization has been studied as a potential target to decrease inflammatory response in sepsis and inflammation-related diseases. Its role in the setting of inflammatory…
  • 2018 American Transplant Congress

    Donor-Derived Cell-Free DNA Outperforms Serum Creatinine Changes for Identifying Kidney Transplant Rejection

    M. Weir,1 D. Hiller,2 J. Yee,2 A. Matas.3

    1University of Maryland School of Medicine, Baltimore, MD; 2CareDx, Brisbane, CA; 3University of Minnesota School of Medicine, Minneapolis, MN.

    Purpose: In the DART study, donor-derived cell-free DNA (dd-cfDNA) discriminated biopsy-based diagnosis of active rejection in kidney transplant patients but serum creatinine (sCr) level did…
  • 2018 American Transplant Congress

    NK Cells in Allograft Kidney Biopsies during Rejection: Detection, Quantification, and Precise Localization Using Multiplex Immunofluorescence

    M. Terada,1 J. Duong Van Huyen,2 F. Drieux,4 C. Legendre,3 P. Bruneval,1 M. Rabant.2

    1Pathology Department, Georges Pompidou European Hospital, Paris, France; 2Pathology Department, Necker-Enfants Malades Hospital, Paris, France; 3Kidney Transplantation Department, Necker-Enfants Malades Hospital, Paris, France; 4Pathology Department, Centre Henri Becquerel, Rouen, France.

    Introduction: Among the complex cellular interplay engaged in renal rejection, recent transcriptomic analysis of renal biopsies has detected NK cell transcripts in the setting of…
  • 2018 American Transplant Congress

    Urinary Chemokine CXCL-10 in Long Term Renal Transplant Patients Associates with Urinary Tract Infections and Microvascular Damage

    G. Irish,1,2 M. Hockley,1,2 S. Kireta,1,2 J. Johnson,1,2 R. Carroll.1,2

    1Central and Northern Adelaide Renal and Transplantation Service, Royal Adelaide Hospital, Adelaide, South Australia, Australia; 2The Faculty of Health and Medical Sciences, The University of Adelaide, Adelaide, South Australia, Australia.

    Non-invasive biomarkers are needed to predict rejection post kidney transplantation. In the early transplant period, urinary CXCL-9 and CXCL-10 associate with rejection. We assessed the…
  • 2018 American Transplant Congress

    Kidney Transplantation in ESKD Patients with a History of Sickle Cell Disease/Trait

    A. Lee, G. Malat, M. Harhay, L. Levin, G. Xiao, S. Guy, D. Reich, K. Ranganna.

    Department of Medicine, Division of Nephrology & Hypertension, Drexel University College of Medicine, Philadelphia, PA.

    Introduction:Kidney transplantation in Sickle Cell Disease patients is fraught with complications, including increased risk of infection and thrombosis. We present long term outcomes of patients…
  • 2018 American Transplant Congress

    Contemporary Desensitization with Low Dose Rituximab Ensures Kidney Transplant Outcome beyond ABO Blood Type Incompatibility:A Comparison between past Regimens in Single Institute

    H. Harada, Y. Wada, A. Mitsuke, T. Hirose, N. Fukuzawa, T. Seki.

    Kidney Transplant Surgery and Urology, Sapporo City General Hospital, Sapporo, Japan.

    INTRODUCTION: An ABO incompatible kidney transplant (ABOiKT) requires desensitization (DS). The ways of DS have been changed chronologically and the outcome could have been subsequently…
  • 2018 American Transplant Congress

    Using Machine Learning and Simulation to Compare High Risk Kidney Transplant Survival to Waiting for a Non High Risk Organ

    E. Mark, D. Goldsman, P. Keskinocak, B. Gurbaxani.

    H. Milton Stewart School of Industrial and Systems Engineering, Georgia Institute of Technology, Atlanta, GA.

    The purpose of this study is to help patients decide whether to accept a kidney from a donor with a potential disease. We consider infectious…
  • 2018 American Transplant Congress

    Early Infectious Outcomes of Older Adults Undergoing Kidney Transplantation (KT). A Case Control Study

    M. Hemmersbach-Miller,1,2 K. Schmader.3

    1Infectious Diseases, Duke University Medical Center, Durham, NC; 2Duke Clinical Research Institute, Durham, NC; 3Geriatrics, Duke University Medical Center, Durham, NC.

    Study Purpose: Our aim was to investigate if among older KT recipient, the types of infections, number of rejections, graft and patient survival in the…
  • 2018 American Transplant Congress

    Diabetic Nephropathy after Kidney Transplantation in Patients with Pre-Transplantation Type II Diabetes May Occur Later and Be Less Common Than Previously Thought

    A. Cimeno, J. Munley, S. Sultan, M. Weir, S. Bartlett, C. Drachenberg, A. Hararian, J. Bromberg, J. Scalea.

    Surgery, University of Maryland, Baltimore, MD.

    Background: Classical medical teaching suggests that diabetic nephropathy occurs more quickly in transplanted kidneys than in the native kidneys. The largest report of post-transplantation diabetic…
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