Am J Transplant, Volume 18, Suppl 3 Archives - Page 79 of 211 - ATC Abstracts

2018 American Transplant Congress
Analyzing Geographic Disparity in the US Heart Allocation System
F. Karami,¹ M. Nayebpour,² M. Gentili,¹ N. Koizumi,² A. Rivard.³
¹Industrial Engineering, University of Louisville, Louisville, KY; ²Schar School of Policy and Government, George Mason University, Arlington; ³Department of Radiology, Cleveland Clinic, Abu Dhabi, United Arab Emirates.
Introduction: In the United States, the system to allocate solid organs for transplantation is regulated and maintained by the United Network for Organ Sharing (UNOS).…
2018 American Transplant Congress
Survey of Rabbit Anti-Thymocyte Globulin Usage for Kidney Transplant Induction Therapy in the United States
K. Foster,¹ A. Dodson,² K. Gutierrez.²
¹Samford University McWhorter School of Pharmacy, Birmingham, AL; ²Comprehensive Transplant Institute, UAB Hospital, Birmingham, AL.
Background: Rabbit anti-thymocyte globulin (rATG) has become the most widely used induction agent in kidney transplantation (KTx) and has recently received FDA approval for this…
2018 American Transplant Congress
Autologous Adipose-Derived Stem Cells with In Vivo Immunomodulatory Properties Can Be Generated in Allograft Recipients under Immunosuppression
A. Sicard,¹ J. Rodriguez,² P. Petruzzo,³ J. Kanitakis,⁴ O. Damour,² L. Badet,⁵ A. Gazarian,⁶ F. Buron,¹ O. Thaunat,¹ K. Tarte,⁷ C. Mesnard,⁷ C. Auxenfans,² E. Morelon.¹
¹Department of Transplantation, Nephrology and Clinical Immunology, Edouard Herriot Hospital, Lyon, France; ²Cells and Tissue Bank, Edouard Herriot Hospital, Lyon, France; ³University of Cagliari, Cagliari, Italy; ⁴Department of Dermatology, Edouard Herriot Hospital, Lyon, France; ⁵Department of Urology and Transplantation, Edouard Herriot Hospital, Lyon, France; ⁶Clinique du Parc, Lyon, France; ⁷University Hospital of Rennes, Rennes, France.
PurposeTo determine if it is possible to generate mesenchymal stem cells (MSC) with potent in vivo immunomodulatory properties in allograft recipients under immunosuppression, we analyzed…
2018 American Transplant Congress
A Retrospective Review of De Novo Coccidioidomycosis among Remote Solid Organ Transplant Recipients in Arizona
T. Zangeneh,¹ J. August,¹ N. Beatty,¹ K. Asbury,² L. Mi,² J. Blair.²
¹Medicine/Division of Infectious Diseases, University of Arizona/Banner University Medical Center/Valley Fever Center for Excellence, Tucson, AZ; ²Medicine/Division of Infectious Diseases, Mayo Clinic Hospital, Phoenix, AZ.
Background: Solid organ transplant (SOT) recipients residing in a Coccidioides-endemic region that acquire infection are at risk for complicated and protracted infection. Following transplantation, prophylaxis…
2018 American Transplant Congress
Characterization of Viral and Host Cell Genomic Alterations in EBV+ PTLD
Y. Balachandran,¹ M. McPherson,¹ S. Boyd,² C. Esquivel,¹ S. Krams,¹ O. Martinez.¹
¹Abdominal Transplant, Stanford University, Stanford; ²Pathology, Stanford University, Stanford.
Post-transplant lymphoproliferative disorder (PTLD) is a potentially fatal complication of organ transplantation characterized by abnormal proliferation of lymphoid cells in the setting of immunosuppression after…
2018 American Transplant Congress
Risk Factors and Outcomes with Extended-Spectrum Beta-Lactamase-Producing Enterobacteriaceae Bloodstream Infections among Solid Organ Transplant Recipients
J. Anesi,¹ E. Blumberg,¹ E. Lautenbach,¹ P. Tamma,² K. Thom,³ K. Alby,¹ W. Bilker,¹ J. Omorogbe,¹ P. Tolomeo,¹ A. Werzen,³ K. Nemati,² J. Han.¹
¹University of Pennsylvania, Philadelphia, PA; ²Johns Hopkins University, Baltimore, MD; ³University of Maryland, Baltimore, MD.
Objective: Solid organ transplant recipients (SOTR) have been significantly impacted by the emergence of multidrug-resistant bacteria, including extended-spectrum beta-lactamase (ESBL)-producing Enterobacteriaceae (EB). We determined the…
2018 American Transplant Congress
MERTK Mediates Transplant Tolerance via IFN-a Regulation of MDSCs and Tregs
L. Zhang, M. DeBerge, E. Thorp, X. Luo.
Northwestern University Feinberg School of Medicine, Chicago.
Introduction: MERTK is one of the TAM receptor tyrosine kinases (RTKs) that mediate homeostatic phagocytosis of apoptotic cells, and transmit regulatory signals that modulate immune…
2018 American Transplant Congress
Pilot Study of Plasma Cell Niche-Targeted Therapy for Enhancement of Proteasome Inhibitor Effectiveness
S. Tremblay,¹ C. Castro-Rojas,² J. Driscoll,¹ S. Knechtle,³ A. Shields,¹ R. Alloway,¹ H. Singh,² D. Hildeman,² E. Woodle.¹
¹UCincinnati, Cincinnati; ²Cincinnati Children's, Cincinnati; ³Duke, Durham.
HLA antibody (Ab)-secreting bone marrow (BM) plasma cell (PC) survival depends on niche occupancy via a CXCR4 (PC)-CXCL12 (BM stromal cell) interaction. Plerixafor inhibits CXCR4-CXCL12…
2018 American Transplant Congress
Robotic Assisted Live Donor Kidney Transplantation – Technique and Outcomes
H. Pahari,¹ B. Waldman,² J. Stracke,¹ L. Malinzak,¹ J. Denny,¹ D. Kim,¹ W. Jeong,³ M. Menon,³ A. Yoshida.¹
¹Transplant Surgery, Henry Ford Hospital, Detroit, MI; ²Wayne State University, Detroit, MI; ³Urology, Henry Ford Hospital, Detroit, MI.
Background: Robotic assisted kidney transplantation (RAKT) is now a feasible minimally invasive option in place of open living donor kidney transplant (OKT). Here, we briefly…
2018 American Transplant Congress
Frequency of Whole-Organ in Lieu of Split-Liver Transplantation over the Last Decade: Children Experienced Increased Wait Time and Death
P. Valentino,¹ S. Emre,² L. Li,³ Y. Deng,³ G. Gan,³ D. Mulligan,² U. Ekong,¹ M. Rodriguez-Davalos.⁴
¹Pediatrics, Hepatology, Yale University, New Haven, CT; ²Surgery, Transplant, Yale University, New Haven, CT; ³Yale Center for Analytical Sciences, Yale University, New Haven, CT; ⁴Surgery, Transplant, Primary Children's Hospital, Salt Lake City, UT.
Background: Organ shortage is a barrier in liver transplantation (LT). Split liver transplantation (SLT) increases organ utilization where a donor provides segmental grafts to 2…