Am J Transplant, Volume 18, Suppl 3 Archives - Page 73 of 211 - ATC Abstracts

2018 American Transplant Congress
LAG-3 Deletion Upregulates Memory in a Dendritic Cell-Dependent Process
S. Gibney,¹ M. Efre,¹ T. Ashry,¹ C. Yang,¹ T. O'Shea,^1,2 R. White,² P. Russell,¹ J. Madsen,¹ R. Colvin,² A. Alessandrini.^1,2
¹Center for Transplantation Sciences, Department of Surgery, Massachusetts General Hospital, Boston, MA; ²Department of Pathology, Massachusetts General Hospital, Boston, MA.
Introduction. Cardiac transplantation is critical for management of severe heart failure, but cardiac allografts frequently undergo chronic T-cell-mediated allograft rejection. Our research demonstrates that Lymphocyte…
2018 American Transplant Congress
Thymus Co-Transplantation Promotes Donor-Specific Tolerance in Allogeneic Heart Transplantation
J. Kwun,¹ J. Li,² C. Rouse,³ J. Park,¹ A. Kirk,¹ L. Markert.²
¹Surgery, Duke University, Durham, NC; ²Pediatrics, Duke University, Durham, NC; ³Laboratory Animal Resources, Duke University, Durham, NC.
Background: Allogeneic thymus has been investigated to achieve donor-specific tolerance in organ transplantation. Often thymus co-transplantation induces long-term graft survival in immunodeficient and total lymphoid…
2018 American Transplant Congress
The LncRNA MALAT1 Induces Tolerogenic DCs and Antigen Specific Tregs Subsequently Mediating Cardiac Allograft Tolerance in Mice via MiR-155/DC-SIGN/IL10 Axis
M. Zhang,^1,2 J. Wu,^1,2 H. Zhang,^1,2 M. Liu,^1,2 Y. Zheng,^1,2 X. Jin,^1,2 S. Li,^1,2 Q. Zhao,^1,2 X. Liu,^1,2 Y. Sun,^1,2 B. Yu.^1,2
¹Department of Cardiology, The Second Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang, China; ²The Key Laboratory of Myocardial Ischemia, Harbin Medical University, Ministry of Education, Harbin, Heilongjiang, China.
Background: Tolerogenic dendritic cells(DCs) by shaping T cells immunity and inducing Tregs play critical roles in the induction of allograft tolerance in transplantation. Long noncoding…
2018 American Transplant Congress
Regulation of Indoleamine 2,3-Dioxygenase in Porcine Kidney Transplants
Y. Wang,¹ X. Fang,¹ D. Kleven,¹ C. Ho,² S. Nahman,^1,3 T. Merchen.¹
¹Augusta University, Augusta, GA; ²Gift of Life Michigan, Ann Arbor, MI; ³Norwood VAMC, Augusta, GA.
Indoleamine 2,3-dioxygenase (IDO) is an endogenous immunosuppressant exerting its effects through tryptophan depletion and kynurenine generation. Kynurenine 3-monooxygenase (KMO) is a downstream enzyme from IDO…
2018 American Transplant Congress
Normothermic Ex-Vivo Kidney Perfusion Restores the Genetic Profile of Marginal Kidney Grafts Subjected to Warm Ischemia
P. Urbanellis,¹ M. Hamar,¹ I. Linares,¹ D. Kollmann,¹ S. Ganesh,¹ R. John,¹ P. Yip,¹ I. Mucsi,¹ A. Ghanekar,¹ D. Bagli,² A. Konvalinka,¹ D. Grant,¹ L. Robinson,² M. Selzner.¹
¹University Health Network, Toronto, ON, Canada; ²SickKids Hospital, Toronto, ON, Canada.
Background: Increasing evidence demonstrates the superiority of normothermic ex-vivo kidney perfusion (NEVKP) over cold storage (CS) for marginal renal grafts. To account for this improvement,…
2018 American Transplant Congress
The Overriding Importance of HLA-DR Donor-Specific Antibody That is Correlated to CAV after Heart Transplant
E. Kransdorf, J. Patel, M. Kittleson, S. Dimbil, R. Levine, D. Geft, D. Chang, L. Czer, J. Kobashigawa.
Cedars Sinai Medical Center, Los Angeles.
Purpose: Class II donor specific anti-HLA antibodies (DSA) have been correlated to subsequent CAV development. More specifically, HLA-DQ has been most reported for CAV development.…
2018 American Transplant Congress
Congestive Hepatic Fibrosis: Correlation with Cardiac Hemodynamics and Changes after VAD or Cardiac Transplant
S. Dhingra,¹ A. Segura,³ N. Cortes-Santiago,¹ M. Schwartz,⁵ S. Mittal,⁴ P. Jalal,² G. Sood.²
¹Pathology and Immunology, Baylor College of Medicine, Houston, TX; ²Surgery, Division of Abdominal Transplantation, Baylor College of Medicine, Houston, TX; ³Cardiovasular Pathology, Texas Heart Institute, Houston, TX; ⁴Gastroenterology, Kelsey Seybold Clinic, Houston, TX; ⁵Pathology, Houston Methodist Hospital, Houston, TX.
Background: Chronic heart failure causes chronic passive congestion of liver that can progress to advanced fibrosis. Liver biopsy is performed for assessment of fibrosis to…
2018 American Transplant Congress
Heart Transplantation in Patients with Complex Congenital Heart Disease
M. Kittleson, J. Patel, E. Kransdorf, S. Dimbil, R. Levine, D. Geft, D. Chang, L. Czer, J. Kobashigawa, R. Garg, E. Zahn.
Cedars Sinai Medical Center, Los Angeles.
Purpose: As medical and surgical management of complex congenital heart disease (CCHD) improves, patients may survive into adulthood to suffer from end-stage heart failure and…
2018 American Transplant Congress
Evanescent Antibodies: A Report on the Natural History of Anti-Blood Group A₂ Antibodies and Their Rapid Resolution in Patients Awaiting A₂ to B Transplantation
S. Radomski, S. Rosen-Bronson, D. Li, M. Awwad, G. Vranic, B. Javaid, P. Abrams, S. Yi, M. Cooper, A. Gilbert.
Medstar Georgetown Transplant Institute, Medstar Georgetown University Hospital, Washington, DC.
Introduction: Despite the benefits of A2 to B transplants, centers have been reluctant to adopt such a program due to unanswered questions including whether elevation…
2018 American Transplant Congress
Kidney Transplantation in Older Recipients: Preemptive High KDPI Kidney vs. Lower KDPI Kidney after Varying Dialysis Vintage
B. Chopra, S. Hussain, K. Sureshkumar.
Nephrology and Hypertension, Allegheny General Hospital, Pittsburgh, PA.
Dialysis vintage is an independent predictor of adverse long-term kidney transplant outcomes. Transplantation of "marginal" kidneys also results in inferior outcomes. We sought to analyze…