ATC Abstracts

American Transplant Congress abstracts

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  • 2018 American Transplant Congress

    Kidney Allografts Confer Tolerance upon Co-Transplanted Heart Allografts by Promoting Tregs

    C. Yang,1 T. Ashry,1 I. Rosales,2 J. Ge,1 T. O'Shea,1 R. White,2 P. Russell,1 J. Madsen,1 R. Colvin,2 A. Alessandrini.1

    1Center for Transplantation Sciences, Department of Surgery, Massachusetts General Hospital, Boston; 2Department of Pathology, Massachusetts General Hospital, Boston.

    The same mixed chimerism-based protocol that induces tolerance of nonhuman primate kidney allografts results in rejection of heart allografts. However, when the two organs from…
  • 2018 American Transplant Congress

    Association between Everolimus Trough Levels, Onset of Related Adverse Events, and Treatment Discontinuation after Liver Transplantation: 24-Month Results from the H2304 Study

    J. Fung,1 F. Saliba,1 H. Schlitt,1 G. Junge,2 K. McCague,3 D. Patel,3 M. Charlton.1

    1H2304 Study Group, Chicago; 2Novartis Pharma AG, Basel, Switzerland; 3Novartis Pharmaceuticals Corporation, East Hanover.

    Purpose: Evaluation of mammalian target of rapamycin inhibitor (mTORi)-related adverse events (AEs) and drug trough levels (C0) at onset may aid their management in liver…
  • 2018 American Transplant Congress

    Enhancement of Endogenous omega-3 Protect against Ischemia-Reperfusion Renal Injury in Fat-1 Mice

    D. Choi,1 Y. Ham,1 K. Na,1 K. Lee,1 J-.J. Kim,1,2 J. Jeong.1,3

    1Nephrology, Chungnam National University, Daejeon, Korea; 2Biomedical Science, Jungwon University, Chungbuk, Korea; 3Medical Science, Chungnam National University, Daejeong, Korea.

    Introduction : Fat-1 transgenic mice produce [omega]3-Polyunsaturated fatty acids ([omega]3-PUFAs) from [omega]6-Polyunsaturated fatty acids ([omega]6-PUFAs) without a dietary [omega]3-PUFAs supplement, leading to a high accumulation…
  • 2018 American Transplant Congress

    Liver Biopsy Fibrosis Not Liver Imaging Predicts Survival after Heart Transplant

    J. Patel, M. Kittleson, E. Kransdorf, R. Levine, S. Dimbil, D. Geft, D. Chang, L. Czer, J. Kobashigawa.

    Cedars Sinai Medical Center, Los Angeles.

    Purpose: Hepatic dysfunction is common in patients with cardiomyopathy being evaluated for heart transplant (HT). ISHLT guidelines highlight the need for liver evaluation in patients…
  • 2018 American Transplant Congress

    Kidney Graft Outcomes in Combined Heart-Kidney Transplantation: A UNOS Database Analysis 2000-2015

    A. Riaz, O. Adebiyi, D. Mishler, M. Yaqub, T. Taber, A. Sharfuddin.

    Indiana University, Indianapolis.

    Background: Combined Heart-Kidney Transplantation (CHKT) is the optimal therapy for patients with advanced renal dysfunction. Our aim was to analyze kidney specific graft outcomes in…
  • 2018 American Transplant Congress

    Risk of Infection in Treatment of Acute Cellular Rejection in Heart Transplant Recipients

    T. Fallah, A. Logan, A. Rumore, C. Doligalski.

    Tampa General Hospital, Tampa, FL; University of North Carolina, Chapel Hill, NC.

    There has been no publication of the incidence of infection (infxn) after the treatment of acute cellular rejection (ACR) in heart transplant recipients (HTR). We…
  • 2018 American Transplant Congress

    Changes in Gene Expression of Selected Genes in Patient with Type 1 Diabetes in Peripheral Blood

    M. Klak, J. Cichoń, F. Ambrożkiewicz, A. Berman, M. Serwańska-Świętek, M. Wszoła.

    Foundation for Research and Science Development, Warsaw, Poland.

    Insulin, a main anabolic peptide hormone, regulates metabolism of carbohydrates, proteins, lipids and affects DNA synthesis or apoptosis. Lack of insulin secretion by destroyed beta…
  • 2018 American Transplant Congress

    A Decade of Dual Kidney Transplantation Reveals Excellent Patient Outcomes from Otherwise Discarded Organs

    I. Rajput, S. Farid, A. Hakeem, M. Jameel, N. Ahmad, O. Masood.

    Department of Organ Transplantation, St. James's University Hospital, Leeds, United Kingdom.

    IntroductionBridging the disparity between the kidney waiting list and donor pool remains challenging. For highly sensitised patients and older recipients the wait is contributing to…
  • 2018 American Transplant Congress

    Kidney Transplant Outcomes in Patients with CPRA Values > 98% after Implementation of the New OPTN/UNOS Kidney Allocation System (KAS): A Single Center Study Update

    N. Kaur,1 M. Kamoun,2 J. Kearns,2 J. Trofe-Clark,1 P. Abt,3 M. Levine,3 S. Goral.1

    1Department of Medicine, Renal-Electrolyte and Hypertension Division, Hospital of the University of Pennsylvania, Philadelphia; 2Pathology and Laboratory Medicine, Hospital of the University of Pennsylvania, Philadelphia; 3Surgery, Hospital of the University of Pennsylvania, Philadelphia.

    Background: Sensitized patients in the past have had prolonged waiting times and greater incidence of death while on the waiting list. On December 4, 2014,…
  • 2018 American Transplant Congress

    Impact of Immunogenicity on Kidney Allograft Survival in Patients Treated with Induction Therapy

    D. Bekbolsynov, B. Mierzejewska, M. Rees, J. Ortiz, O. Ekwenna, S. Stepkowski.

    University of Toledo, Toledo.

    Background. The induction therapy is currently used in the majority of kidney transplant recipients, regardless of their level of donor/recipient compatibility. We examined whether lower…
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