Am J Transplant, Volume 18, Suppl 3 Archives - Page 69 of 211 - ATC Abstracts

2018 American Transplant Congress
Influence of Initial Tumor Burden and Wait Times on Post-Transplant Outcomes after Down-Staging of Hepatocellular Carcinoma (HCC)
N. Mehta, J. Dodge, F. Yao.
UCSF, San Francisco.
Background: A new national policy has adopted the UNOS Region 5 down-staging protocol for liver transplant (LT) in HCC meeting the following inclusion criteria -…
2018 American Transplant Congress
OX40 Costimulation Prevents Induction of Foxp3⁺ Tregs through Upregulation of Novel Repressors of Foxp3 Gene Expression
X. Zhang,¹ X. Xiao,¹ P. Lan,¹ J. Li,¹ Y. Dou,¹ W. Chen,¹ N. Ishii,² S. Chen,¹ E. Taparowsky,³ X. Li.^1,4
¹Immunobiology & Transplant Research Center, Houston Methodist Hospital, Houston, TX; ²Department of Microbiology and Immunology, Tohoku University, Sendai, Japan; ³Department of Biological Sciences, Perdue University, Lafayette, IN; ⁴Department of Surgery, Weill Cornell Medical College of Cornell University, New York, NY.
Foxp3+ Tregs are essential for the induction of transplant tolerance and OX40 costimulation is known to break transplant tolerance. The exact mechanism of OX40 in…
2018 American Transplant Congress
The Cost Savings of Preemptive Kidney Transplantation
P. Dean,¹ H. Heien,² K. Swanson,² B. Borah,² L. Sangaralingham,² J. Naessens,² M. Stegall.¹
¹Division of Transplantation Surgery, Mayo Clinic, Rochester, MN; ²Robert D. and Patricia E. Kern Center for the Science of Health Care Delivery, Mayo Clinic, Rochester, MD.
Introduction: Preemptive kidney transplantation (PreKTx) is associated with improved patient survival and quality of life. The goal of this study was to compare the costs…
2018 American Transplant Congress
Identification of Macrophage Innate Receptors in Recognition and Rejection of Allogeneic Non-Self in Transplantation
P. Lan,¹ H. Dai,² W. Liu,¹ S. Chen,¹ L. Minze,¹ Y. Dou,¹ Y. Zhao,¹ W. Chen,¹ X. Xiao,¹ P. Pan,¹ H-.H. Chen,¹ F. Lakkis,² X. Li.¹
¹Immunobiology and Transplant Science Center, Houston Methodist Research Institute, Houston, TX; ²Starzl Transplantation Institute, University of Pittsburgh, Pittsburgh, PA.
Recent studies in several labs provide compelling evidence that the innate immune cells can recognize and reject allogeneic non-self in an antigen-specific manner, but the…
2018 American Transplant Congress
Non-Invasive Proteomics to Detect Biomarkers for Kidney Allograft Dysfunction
M. Watson,¹ M. Srivastava,³ D. Little,¹ O. Eidelman,³ R. Nee,¹ A. Bera,³ J. Karaian,³ D. Oliver,¹ H. Pollard,³ R. Jindal.²
¹Nephrology, USU-Walter Reed, Bethesda, MD; ²Surgery, USU-Walter Reed, Bethesda, MD; ³Anamtomy, Physiology and Genetics, USU-School of Medicine, Bethesda, MD.
Background: Non-invasive biomarkers are needed for monitoring patients to predict early acute rejection (AR). We hypothesized that protein biomarkers released from rejecting allograft tissues can…
2018 American Transplant Congress
Intragraft MicroRNA Transcriptome of Acute Antibody Mediated Rejection of Human Kidney Allografts
H. Yang,¹ K. Akat,² C. Li,¹ C. Snopkowski,¹ Z. Khan,¹ D. Dadhania,¹ T. Tuschl,² M. Suthanthiran,¹ T. Muthukumar.¹
¹Weill Cornell Medicine, New York; ²Rockefeller University, New York.
BackgroundMicroRNAs (miRNA) are master regulators of gene expression and are potential therapeutic targets. Intragraft miRNA transcriptome of acute antibody rejection (AMR) of human kidney allograft…
2018 American Transplant Congress
Identification of Exosomal Proteins from Human Lung Transplant Recipients
S. Bansal,¹ P. Pirrotte,² M. Saltzman,² K. Garcia,² M. Sharma,¹ M. Gunasekaran,¹ M. Smith,¹ R. Bremner,¹ T. Mohanakumar.¹
¹Norton Thoracic Institute, St. Joseph's Hospital & Medical Center, Phoenix; ²Collaborative Center for Translational Mass Spectrophotometry Translational Genomics Research Institute, Phoenix.
Molecular mechanisms involved in rejection following human lung transplantation are not well understood. Goal of this study is to identify proteomic signatures in the circulating…
2018 American Transplant Congress
Changes in Phenotype, Immune Suppressive, Function, and Gene Expression of Myeloid Derived Suppressor Cells in Patients Given Combined Kidney and Hematopoietic Cell Transplants in a Tolerance Protocol
K. Jensen,¹ P. Zheng,² J. Xuhuai,² A. Saraswathula,¹ J. Scandling,³ S. Busque,⁴ J. Shizuru,⁵ R. Lowsky,⁵ A. Shori,⁴ H. Maecker,² E. Engleman,¹ E. Meyer,⁵ S. Strober.¹
¹Immunology, Stanford School of Medicine, Stanford, CA; ²Human Immune Monitoring Center, Stanford School of Medicine, Stanford, CA; ³Nephrology, Stanford School of Medicine, Stanford, CA; ⁴Surgery, Stanford School of Medicine, Stanford, CA; ⁵Blood & Marrow Transplantation, Stanford School of Medicine, Stanford, CA.
Tolerance induction after combined organ and hematopoietic cell transplantation can be achieved using conditioning with total lymphoid irradiation (TLI) and anti-thymocyte globulin (ATG), in both…
2018 American Transplant Congress
TGR5-Mediated AMPK/mTOR Signaling Regulates Macrophage Migration and Polarization in Liver Ischemia Reperfusion
S. Zhou, H. Zhou, R. Liu, F. Zhang, X. Wang, L. Lu.
Liver Transplantation Center, First Affiliated Hospital, Nanjing Medical University, Nanjing, Jiangsu, China.
Background: Although the plasma membrane-bound G protein–coupled bile acid receptor (TGR5) exerts protective roles in various inflammatory diseases, little is known about the effects and…
2018 American Transplant Congress
The Role of NKT Cell /IL-17 Axis in the Autoimmune Lupus Nephritis
J. An,¹ Y. Kim,² M. Yu,² J. Lee,¹ C. Lee,³ Y. Kim,² S. Yang.⁴
¹Internal Medicine, Boramae Medical Center, Seoul, Korea; ²Internal Medicine, Seoul National University Hospital, Seoul, Korea; ³Internal Medicine, Cheju Halla General Hospital, Cheju, Korea; ⁴Internal Medicine, Seoul National University Kidney Research Institute, Seoul, Korea.
CD1d-restrictive NKT cells may modulate various chronic autoimmunity through secreting multiple cytokines, but the functional relationships between the different subpopulation still are poorly understood. The…