Am J Transplant, Volume 18, Suppl 3 Archives - Page 69 of 211 - ATC Abstracts

2018 American Transplant Congress
The MicroRNA Landscape of EBV+ and EBV- PTLD
Y. Balachandran,¹ H. Zimmermann,² C. Esquivel,¹ S. Krams,¹ R. Trappe,² O. Martinez.¹
¹Transplant Immunology Laboratory/Division of Abdominal Transplant, Stanford University, Stanford; ²Department of Haematology and Oncology, DIAKO Ev. Diakonie-Krankenhaus Bremen, Bremen, Germany.
Post-transplant lymphoproliferative disorder (PTLD) is a potentially fatal complication of organ transplantation characterized by abnormal proliferation of lymphoid cells in the setting of immunosuppression after…
2018 American Transplant Congress
Contribution of mTOR Signaling to the β-Catenin Pathway in Regulatory T Cells
F. Marti, L. Turcios, A. Mohamed, M. Mitov, D. Butterfield, R. Gedaly.
Surgery, University of Kentucky, Lexington, KY.
Background: A growing body of evidence recognizes the balance between graft-reactive effector T cells and graft-protective regulatory T cells (Tregs) as the ultimate determinant of…
2018 American Transplant Congress
Organ Transplantation Associated with High Incidence of Anal Cancer and Pre-Cancer Lesions among HIV-Infected Women and Men
P. Chin-Hong,¹ B. Barin,² M. Berry,¹ M. DaCosta,¹ T. Darragh,¹ L. Rosenthal,³ S. Bartlett,⁴ D. Dieterich,⁵ F. Poordad,⁶ N. Nissen,⁶ M. Wong,⁷ P. Stock,¹ J. Palefsky.¹
¹University of California, San Francisco, San Francisco; ²EMMES, Rockville; ³Columbia University, New York; ⁴University of Maryland, Baltimore; ⁵Icahn School of Medicine at Mount Sinai, New York; ⁶Cedars-Sinai Medical Center, Los Angeles; ⁷Beth Israel Deaconess Medical Center, Boston.
Objective: HIV-infected women and men and transplant recipients are two populations at increased risk of HPV-associated anal cancer but there is little published data. We…
2018 American Transplant Congress
Unsupervised Analysis of the Alloimmune Response in a Novel Model of Vascularized Composite Allotransplantation
J. Harden, A. Sang, X. Qu, C. Esquivel, O. Martinez, S. Krams.
Department of Surgery/Division of Abdominal Transplantation, Stanford University, Stanford, CA.
Vascularized composite allografts consists of skin, muscle, bone, and other tissues, and is more immunogenic than solid-organ allografts. Our laboratory developed a murine model to…
2018 American Transplant Congress
Dual Inhibition of PI3K and mTORC2 Causes ERK Hyperactivation Induced by HLA-II Antibody in Human Endothelium
Y-.P. Jin, E. Reed.
Pathology and Laboratory Medicine, David Geffen School of Medicine, UCLA, Los Angeles, CA.
Background: Endothelial cells (EC) line the inner surface of blood vessels and serve as the interface between recipient circulating blood and the donor allograft. Transplant…
2018 American Transplant Congress
A Follow-Up Report on the Use of IVIG+Rituximab to Reduce Donor Specific Antibodies and Improve Transplant Rates in Highly-Sensitized Patients Awaiting Deceased Donor Kidney Transplantation
R. Najjar, E. Huang, A. Vo, J. Choi, K. Lim, S. Louie, A. Peng, S. Sethi, M. Toyoda, X. Zhang, S. Jordan.
Medicine/Nephrology, Cedars Sinai Medical Center, Los Angeles, CA.
Introduction: Desensitization (DES) with IVIG/rituximab is associated with a reduction in donor specific antibodies (DSA), improved transplant rates and outcomes in highly-sensitized (HS) patients. We…
2018 American Transplant Congress
Kidney Transplantation and Progression of Peripheral Arterial Disease in the Ipsilateral Lower Extremity
A. Rasmussen,¹ R. Moore,¹ T. Schuler,¹ G. Todd,¹ K. Wen.²
¹Division of Urology, Department of Surgery, University of Alberta, Edmonton, AB, Canada; ²Division of Nephrology and Transplant Immunology, Department of Medicine, University of Alberta, Edmonton, AB, Canada.
Objectives:We aimed to investigate whether receiving a kidney transplant allograft graft increases the risk of ipsilateral lower limb amputation in patients with pre-existing peripheral arterial…
2018 American Transplant Congress
Estimation of Mortality on the Wait List
S. Asrani, L. Jennings, J. Trotter, G. Klintmalm.
Baylor University Medical Center, Dallas, TX.
Background: Since the introduction of MELD and MELDNa, the waitlist population has changed. Further, serum creatinine is a poor surrogate of renal dysfunction in patients…
2018 American Transplant Congress
Consequences of Being Listed at a Small Pancreas Program
S. Niederhaus,¹ M. Curry,² A. Fox,² J. Fridell,³ J. Odorico.⁴
¹Surgery, University of Maryland, Baltimore, MD; ²UNOS, Richmond, VA; ³Surgery, Indiana University, Indianapolis, IN; ⁴Surgery, University of Wisconsin, Madison, WI.
How pancreas transplant center (PTC) volume affects patient outcomes after listing is unclear. Low volumes may lengthen waiting times or limit access to transplantation. We…
2018 American Transplant Congress
Living Liver Donor Follow-Up: Fewer Than Half of Centers Meet Follow-Up Requirements in the US
A. Thomas, C. Holscher, A. Shaffer, J. Garonzik-Wang, A. Massie, D. Segev, M. Henderson.
JHU, Baltimore.
OPTN/UNOS began requiring 1-year living donor follow-up (LDF) for living liver donors (LLDs) in 2014. Compliance with a similar policy for living kidney donors was…