ATC Abstracts

American Transplant Congress abstracts

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  • 2018 American Transplant Congress

    CMV-Specific CD8+ T-Cell Immune Competence Score as Predictor of Outcome for CMV Infection after Transplantation

    A. Meesing,1 R. Abraham,2 R. Razonable.1

    1Division of Infectious Diseases, Mayo Clinic, Rochester, MN; 2Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN.

    Introduction: Control of cytomegalovirus (CMV) infection after solid organ transplantation (SOT) requires a functional immune system. We assessed the utility of a flow cytometric assay…
  • 2018 American Transplant Congress

    Daptomycin Minimum Inhibitory Concentration (MIC) of Vancomycin Resistant Enterococcal (VRE) Blood Isolates Correlates with Allograft Failure in Orthotopic Liver Transplant (OLT) Recipients

    R. Lee,1 G. Haidar,2 J. Lewis,3 S. Arif,4 J. Hand,5 E. Holaday,6 H. Clauss,6 J. Goldman,7 A. Nellore.1

    1University of Alabama at Birmingham, Birmingham, AL; 2University of Pittsburgh Medical Center, Birmingham, AL; 3University of Virginia, Charlottesville, VA; 4Duke University, Durham, NC; 5Oschner Medical Center, New Orleans, LA; 6Department of Internal Medicine, Temple University, Philadelphia, PA; 7Temple University, Philadelphia, PA; 8Swedish Medical Center, Seattle, WA.

    Background: Enterococci are one of the leading causes of nosocomial infection in after OLT. Unfortunately, treatment options for enterococci that are resistant to first-line agents…
  • 2018 American Transplant Congress

    Isavuconazole – The Real-World Use Experience

    H. Hassouna, V. Athans, K. Brizendine.

    Cleveland Clinic Foundation, Cleveland, OH.

    Isavuconazole (ISV) is a new triazole approved for treatment of mucormycosis and aspergillosis. Data on its effectiveness outside clinical trials and in patients receiving prior…
  • 2018 American Transplant Congress

    BLyS-/- Rats to Prevent Alloantibody Production

    N. Bath,1 B. Verhoven,1 N. Wilson,1 S. Reese,2 L. Coons,1 S. Panzer,2 A. Djamali,2 R. Redfield.1

    1Surgery, University of Wisconsin, Madison, WI; 2Medicine, University of Wisconsin, Madison, WI.

    Introduction: Antibody mediated rejection (AMR) is a major cause of kidney allograft failure. APRIL (A Proliferation Inducing Ligand) and BLyS (B Lymphocyte Stimulator) are two…
  • 2018 American Transplant Congress

    Rhesus-Specific Anti-Thymocyte Globulin as an Adjuvant to Costimulatory-Blockade-Based Immunotherapy

    M. Mulvihill,1 B. Ezekian,1 Q. Gao,1 K. Samy,1 R. Davis,1 F. Leopardi,1 A. Belli,2 W. Flores,2 A. Buzby,2 K. Reimann,2 B. Collins,1 A. Kirk.1

    1Department of Surgery, Duke University, Durham, NC; 2MassBiologics, University of Massachusetts Medical School, Boston, MA.

    Background Belatacept targets de novo alloimmune responses with minimal off target effects in renal transplantation, though adjuvant therapy is required to control costimulation-blockade resistant rejection…
  • 2018 American Transplant Congress

    The Role of Ex Vivo Normothermic Preservation in Minimizing Postreperfusion Syndrome in Liver Transplantation

    A. Hassan, J. Cywinski, Q. Liu, D. Pezzati, D. Yang, L. Liu, G. Iuppa, K. Hashimoto, F. Aucejo, M. Fujiki, B. Eghtesad, S. Irefin, J. Fung, K. Abu-Elmagd, C. Miller, C. Quintini.

    Transplant Surgery, Cleveland Clinic, Cleveland.

    Background:Graft reperfusion holds a major challenge during liver transplantation. NMP may improve post-reperfusion hemodynamics, reduce vasopressor and blood product transfusion.Methods:15 patients with liver transplantation after…
  • 2018 American Transplant Congress

    The Prognostic Implications of Renal Function Recovery and Delayed Graft Function in Kidney Transplantation

    S. Sandal, M. Cantarovich, A. Ramankumar, N. Saberi, C. Saw, D. Baran, P. Chaudhury, S. Paraskevas, J. Tchervenkov.

    MUHC, Montreal, Canada.

    Introduction: Lack of renal function recovery (RFR), 90 days after acute kidney injury (AKI) is a contributor to inferior renal outcomes and mortality. Ischemia and…
  • 2018 American Transplant Congress

    Timeline and Histopathological Characteristics of Graft Failure after Kidney Transplantation: What is Preventable and What is Not?

    S. Parajuli, F. Aziz, N. Garg, B. Muth, M. Mohamed, W. Zhong, B. Astor, D. Mandelbrot, A. Djamali.

    University of Wisconsin, Madison.

    Background: There is limited information on the histopathological characteristics of kidney transplant recipients (KTRs) with graft failure at different post-transplant time intervals. Methods:We addressed this…
  • 2018 American Transplant Congress

    Death-Censored Graft Failure (DCGF) Post Kidney Transplant (KTx) is Usually the Result of Rapid Loss of Function after Periods of Stability

    R. Gaston,1 L. Hunsicker,2 A. Fieberg,3 A. Matas,3 The DeKaf Consortium.

    1CTI Clinical Trial & Consulting, Covington, KY; 2Int. Med., U Iowa, Iowa City, IA; 3Biostatistics and Surgery, U Minnesota, Minneapolis, MN.

    Late graft dysfunction leading to clinically indicated transplant biopsy (KTxBx) is a better predictor of subsequent DCGF than baseline data and early post-transplant events (Gaston…
  • 2018 American Transplant Congress

    Risk Factors and Sequelae of Post-KT Delirium

    M. McAdams DeMarco, A. Mountford, F. Warsame, R. Berkowitz, H. Ying, C. Haugen, D. Brennan, D. Segev.

    JHU, Baltimore.

    Background: Delirium is the acute decline in cognitive function following a noxious insult like surgery. Previous studies in other surgical settings have identified frailty and…
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