ATC Abstracts

American Transplant Congress abstracts

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  • 2018 American Transplant Congress

    Protein S Deficiency as an Independent Risk Factor for Portal Vein Thrombosis in Cirrhotic Patients Awaiting Liver Transplantation

    H-.C. Hung,1 J-.C. Lee,1 C-.H. Cheng,2 Y-.C. Wang,2 T-.H. Wu,2 C-.F. Lee,2 T-.J. Wu,2 H. Chou,2 K-.M. Chan,2 W-.C. Lee.2

    1Department of General Surgery, Chang-Gung Memorial Hospital, Chang-Gung University College of Medicine, Taoyuan, Taiwan; 2Division of Liver and Transplantation Surgery, Chang-Gung Memorial Hospital, Chang-Gung University College of Medicine, Taoyuan, Taiwan.

    Background: Portal vein thrombosis (PVT) in cirrhotic patients not only induces lethal complications on waiting, but also complicates surgical procedures and increases risk during transplantation.…
  • 2018 American Transplant Congress

    The Aggressive Phenotype: Center-Level Characteristics in the Use of Suboptimal Lungs

    M. Kosztowski, E. Bush, X. Luo, A. Thomas, M. Bowring, D. Segev, J. Garonzik Wang.

    Johns Hopkins, Baltimore, MD.

    The disparity between organ supply and demand has led some centers to expand their criteria for donor selection. We explored utilization of suboptimal lungs to…
  • 2018 American Transplant Congress

    Using a Data Analytics Platform to Improve Patient Care in Pediatric Lung Transplantation

    B. Scully,1 K. Hosek,2 D. Dash,2 K. Carberry,1,2 E. Melicoff,3 M. Gazzaneo,3 G. Mallory,3 J. Heinle.1

    1Surgery, Baylor College of Medicine, Houston, TX; 2Outcomes and Impact Services, Texas Children's Hospital, Houston, TX; 3Pediatric Pulmonology, Baylor College of Medicine, Houston, TX.

    PurposeLung transplantation in children remains challenging, requiring extensive infrastructure and expertise. At our institution, we have performed 191 pediatric lung transplants since 2002. We hypothesized…
  • 2018 American Transplant Congress

    Shikonin Inhibits Th17 Development through Repressing STAT3 Activation

    H. Fang,1 R. Zhang,1 F. Liang,1 Q. Chen,2 J. Ochando,3 Y. Ding,1 J. Xu.1

    1Department of Immunology, Capital Medical University, Beijing, China; 2Department of Thoracic Surgery, Chaoyang Hospital, Beijing, China; 3Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY.

    Background: Th17-mediated inflammatory responses are detrimental for allograft acceptance and long-term survival after transplantation. Shikonin is a naphthoquinone pigment isolated from a traditional medicinal herb…
  • 2018 American Transplant Congress

    Multi-Visceral Transplant in an HIV Positive Recipient – One Year Survival

    S. Nagaraju, R. Mangus, J. Fridell.

    Surgery, Indiana University School of Medicine, Indianapolis, IN.

    Human immunodeficiency virus (HIV) is associated with hypercoagulability and thrombotic events. Highly active anti-retroviral therapy (HAART) has improved long term survival. More patients with HIV…
  • 2018 American Transplant Congress

    Host Factors and Clinical Spectrum of Adenovirus Infection in Pediatric Solid Organ Transplantation: A Closer Look at the Infant, the Toddler and the Child

    C. Del Valle Mojica, S. Chen, H. Gans.

    Pediatrics, Stanford University, Stanford, CA.

    Adenovirus (AdV) is increasingly recognized in solid organ transplants (SOT), with reported mortality exceeding 50%. Characterization of AdV infection in the pediatric SOT population is…
  • 2018 American Transplant Congress

    T2Candida for Diagnosis of Candidemia in Solid Organ Transplant Recipients

    T. McCarty, J. Baddley, J. Locke, R. Mannon, D. Eckhoff, V. Rusanov, S. Moser, P. Pappas.

    University of Alabama at Birmingham, Birmingham, AL.

    Purpose: Candidemia is a critical contributor to morbidity following solid organ transplantation (SOT). The purpose of this study is to evaluate the T2Candida assay (T2)…
  • 2018 American Transplant Congress

    Analysis of Circulating CD38+/CD138+ Plasma Cells during Development of De Novo Donor Specific Antibody Responses

    N-.N. Chai, G. Wu, I. Kim, S. Jordan, A. Klein.

    CTC/Surgery, Cedars-Sinai Medical Center, Los Angeles, CA.

    Purpose: Donor specific antibodies (DSA) that emerge following transplantation are indicative of allogenic sensitization and a predisposing factor for antibody mediated rejection. Though various methods…
  • 2018 American Transplant Congress

    Assessing Necroptosis in Brain Dead Kidney Donors: Implications for Predicting Recipient Outcomes

    A. Zmijewska, J. Murphy, J. Chen, J. Zmijewski, R. Mannon.

    Medicine, University of Alabama at Birmingham, Birmingham, AL.

    Introduction: Kidney graft transplant obtained from Brain Dead Donors (BDD) is more frequently associated with development of delayed graft function (DGF) and higher risk of…
  • 2018 American Transplant Congress

    Targeting Calcium Release-Activated Calcium (CRAC) Channel in Non-Human Primate Kidney Transplantation

    J. Kwun,1 B. Ezekian,1 M. Manook,1 J. Park,1 J. Yoon,1 J. Sloan-Lancaster,2 C. Fortier,3 P. Rao,4 S. Knechtle.1

    1Surgery, Duke University, Durham, NC; 2Eli Lilly and Company, Indianapolis, IN, Canada; 3PRCL Research Inc, Montreal, QC, Canada; 4Synta Pharmaceuticals Inc., Lexington, MA.

    [Background] Long-term administration of calcineurin inhibitors (CNIs) successfully controls rejection of transplanted organs. However, the chronic use of these drugs causes organ damage often resulting…
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