ATC Abstracts

American Transplant Congress abstracts

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  • 2018 American Transplant Congress

    Prevention of an Adaptive Immune Response by FDA-Approved Immunosuppressive Agents in Baboons with Pig Artery Patch Xenografts

    T. Yamamoto,1 H. Hara,1 L. Wang,1 Q. Li,1 J. Li,1 H. Zhou,1 D. Eckhoff,1 A. Tector,1 D. Ayares,2 D. Cooper,1 H. Iwase.1

    1Xenotransplantation Program, Department of Surgery, University of Alabama at Birmingham, Birmingham; 2Revivicor, Blacksburg.

    Background: In the pig-to-baboon artery patch model with no immunosuppressive therapy, a graft from a GTKO pig elicits a significant anti-nonGal IgG response, indicating sensitization…
  • 2018 American Transplant Congress

    IgA Recurrence in a Single Center with a Protocol Biopsy Program

    M. Merzkani, N. Lepori, M. El Ters, F. Cosio, H. Amer.

    Mayo Clinic, Rochester, MN.

    The objective of this study was to determine the rate of recurrence of IgA nephropathy in our program aided by protocol biopsies and protocol driven…
  • 2018 American Transplant Congress

    Tissue Talks: Graft´s Histological Findings 10 Years after Belatacept or CNI

    G. Mondragon-Ramirez,1 N. Uribe-Uribe,2 J. Arreola-Guerra,5 R. Reyes-Acevedo,5 M. Vilatoba,3 J. Furuzawa-Carballeda,4 A. Lopez-Toledo,1 G. Mondragon-Salgado,1 J. Alberu.3

    1Inst Mex de Trasplantes, Cuernavaca, Mexico; 2Pathology, Inst Nal de C. Médicas y Nutrición SZ, Mexico City, Mexico; 3Transplantation, Inst Nal de C. Médicas y Nutrición SZ, Mexico City, Mexico; 4Immunology, Inst Nal de C. Médicas y Nutrición SZ, Mexico City, Mexico; 5Transplantation, C Hospital Miguel Hidalgo, Aguascalientes, Mexico.

    The BENEFIT study demonstrated that 7 yrs after kidney transplantation (KT), mean eGFR, patient and graft survival, were significantly higher in the belatacept group than…
  • 2018 American Transplant Congress

    Evolving Etiologies for Readmissions and Their Impact on Graft Survival in Kidney Transplantation

    D. Taber, N. Pilch, Z. Su, C. Mardis, J. Fleming, N. Patel, H. Meadows, P. Mauldin, V. Rao, D. Dubay.

    MUSC, Charleston, SC.

    Background: Although readmissions after kidney transplant are a well-known risk factor for graft loss, it is unclear if certain etiologies are associated with poorer outcomes…
  • 2018 American Transplant Congress

    Impact of Local Liver Supply on Liver Offer Acceptance

    M. Bowring,1 S. Zhou,1 A. Massie,1 S. Gentry,1,2 D. Segev.1

    1JHU, Baltimore; 2US Naval Academy, Annapolis.

    Geographic disparity in access to deceased-donor liver transplantation is well described. The available liver supply in a DSA may affect patient and provider decisions on…
  • 2018 American Transplant Congress

    T Cell-Mediated Rejection Poses Greater Risk to Graft Survival Than Antibody-Mediated Rejection in Heart Transplants

    M. Parkes, K. Famulski, P. Halloran, The INTERHEART Study Group.

    University of Alberta, Edmonton, Canada.

    Purpose: In kidney transplants, failure post-biopsy is associated with acute injury transcript expression reflecting the histologically silent tissue response-to-wounding (JCI 120:1862) and antibody-mediated rejection (ABMR),…
  • 2018 American Transplant Congress

    The Incidence of Polyomavirus-BK and Cytomegalovirus Infections in Renal Transplant Recipients Following Rituximab Administration

    A. Kraljevic, C. D'Agostino, C. Kane, K. Cunningham, A. Shetty, C. Richardson.

    Northwestern Memorial Hospital, Chicago, IL.

    Rituximab is an antibody that binds to the CD20 antigen on B cells resulting in rapid and prolonged depletion. At Northwestern Memorial Hospital, a single…
  • 2018 American Transplant Congress

    Extracellular Microvesicles from Liver Perfusate: microRNAs, Cellular Cross-Talk, and Early-Post Liver Transplant Outcomes

    A. Fernandez,1 O. Ingram,1 S. Bontha,1 U. Erdbruegger,2 L. Musante,2 V. Mas,1 D. Maluf.1

    1Surgery, UVA, Charlottesville; 2Nephrology Division, UVA, Charlottesville.

    Background: Ischemia reperfusion injury (IRI) is a multifactorial process that impact liver graft function. Donor quality plays a critical role during IRI and early graft…
  • 2018 American Transplant Congress

    Nephrosclerosis beyond That Expected for Age is Predictive of Early New-Onset Hypertension (HTN) in Living Kidney Donors (LKD)

    N. Issa,1 L. Vaughan,1 A. Denic,1 V. Nagineni,1 H. Chakkera,2 J. Lieske,1 L. Lerman,1 S. Taler,1 M. Stegall,1 W. Kremers,1 E. Poggio,3 A. Rule.1

    1Mayo Clinic, Rochester, MN; 2Mayo Clinic, Scottsdale, AZ; 3Cleveland Clinic, Cleveland, OH.

    Background: Nephrosclerosis on biopsy (bx) of LKD is associated with older age & HTN. We studied whether nephrosclerosis is predictive of adverse changes early after…
  • 2018 American Transplant Congress

    Low Kidney Supply to Demand Ratio and Multi-Organ Transplant Centers Are Negatively Associated with Pediatric Renal Transplant Rates Post Kidney Allocation System Implementation: An Analysis of OPTN Data

    P. Almond,1 S. Al-Akash,1 D. Stewart,2 A. Robinson.2

    1CPSST Departments of Surgery and Renal Transplantation, Driscoll Children's Hospital, Corpus Christi, TX; 2UNOS, Richmond, VA.

    Under the new kidney allocation system (KAS), pediatric (PED) renal (REN) transplant (Tx) candidates have priority to kidneys from donors with KDPI < 35%. We…
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