ATC Abstracts

American Transplant Congress abstracts

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  • 2018 American Transplant Congress

    Outcomes of Pediatric Donor Liver Grafts for Adult Transplantation: A National Analysis

    J. Yerxa, Q. Gao, U. Scheuermann, R. Davis, D. Vikraman, A. Barbas.

    Surgery, Duke University, Durham, NC.

    Introduction: Utilization of pediatric donor organs for adult transplant has emerged in recent years in response to organ shortage. In this study, we investigate recipient…
  • 2018 American Transplant Congress

    Cognition and Self-Management in Liver Transplant Recipients

    D. Ko,1 L. Bratzke,2 R. Muehrer.2

    1Vanderbilt University, Nashville; 2University of Wisconsin-Madison, Madison.

    Cognitive impairment in the liver transplant (LT) population could negatively affect one's ability to self-manage. This study examined cognition and its relationship with self-management in…
  • 2018 American Transplant Congress

    Acquired Resistance to Transplantation Tolerance as a Result of Prior Pregnancy Requires B Cells

    A. Suah,1 S. Khiew,1 J. Young,1 D. Yin,1 Q. Wang,1 M. Alegre,2 A. Chong.1

    1Surgery, Univeristy of Chicago Medicine, Chicago, IL; 2Medicine, University of Chicago, Chicago, IL.

    Introduction: Clinical data suggest allogeneic pregnancy is a sensitizing event; yet, recent data from mouse models indicates it induces fetal-specific regulatory T cell (Treg) expansion…
  • 2018 American Transplant Congress

    Respiratory Viral Infections Induces Exosomes and Antibodies to Lung Self-Antigens, Kα1Tubulin and Collagen V, Following Human Lung Transplantation

    M. Gunasekaran,1 S. Bansal,1 M. Sharma,1 R. Walia,1 R. Hachem,2 A. Limaye,3 R. Bremner,1 M. Smith,1 T. Mohanakumar.1

    1St. Joseph's Hosp & Med Ctr, Phoenix; 2Washington Univ Sch Med, St. Louis; 3Univ Washington, Seattle.

    Respiratory viral infection (RVI) following human lung transplantation (LTx) increases the risk for chronic rejection. We demonstrated that lung transplant recipients (LTxR) with acute and…
  • 2018 American Transplant Congress

    Impact of KDPI and CPRA on Outcomes in Kidney Transplant Recipients

    S. Sethi, R. Najjar, A. Peng, A. Vo, S. Jordan, E. Huang.

    Cedars Sinai Medical Center, Los Angeles.

    Introduction: The new KAS has led to a marked increase in kidney transplants among highly sensitized recipients, mostly attributable to higher allocation of low KDPI…
  • 2018 American Transplant Congress

    Pneumocystis jiroveci Pneumonia (PJP) in Kidney and Pancreas Transplant Recipients in the Present Era of Routine Post-Transplant Prophylaxis: Risk Factors and Outcomes

    N. Garg, M. Jorgenson, M. Birschbach, J. Descourouez, S. Parajuli, B. Astor, A. Djamali, D. Mandelbrot.

    University of Wisconsin, Madison.

    PJP after transplant (TX) is associated with substantial morbidity and mortality. In the present era of universal and routine implementation of PJP prophylaxis (PPX) during…
  • 2018 American Transplant Congress

    IL-6 Inhibition with Tocilizumab to Promote Tregs and Control Renal Graft Inflammation: A Prospective Randomized Controlled Trial

    S. Chandran, J. Leung, Z. Laszik, Q. Tang, C. Hu, M. Sarwal, F. Vincenti.

    UCSF, San Francisco.

    Background: IL-6, a proinflammatory cytokine & key regulator of Treg/Th17, is strongly associated with renal graft rejection. In theory, IL-6 blockade with tocilizumab (TCZ), a…
  • 2018 American Transplant Congress

    Variation in Cost of Death and Graft Failure across All Solid Organs

    M. Schnitzler,1,2 M. Skeans,2 D. Axelrod,3 K. Lentine,1 H. Randall.1

    1St. Louis Univ, St. Louis, MO; 2SRTR, Minneapolis, MN; 3Lahey Hosp & Med Ctr, Burlington, VT.

    Medicare costs for transplant vary considerably by organ, and costs in the second posttransplant year (Y2) are lower than in the first (Y1). Variability in…
  • 2018 American Transplant Congress

    Lymphatic Endothelium Requires S1PR2 for T Cell Transendothelial Migration

    Y. Xiong,1 W. Piao,1 C. Brinkman,1 L. Li,1 J. Kulinski,2 A. Olivera,2 A. Cartier,3 T. Hla,3 S. Schwab,4 K. Hippen,5 B. Blazar,5 J. Bromberg.1

    1UMB, MD; 2NIH, MD; 3Boston Children's Hospital, MA; 4NYU, NY; 5U. Minnesota, MN.

    Introduction: Sphingosine 1-phosphate (S1P) receptors 1 (S1PR1) and S1PR2 are highly expressed by lymphatic endothelial cells (LEC), while T cells express S1PR1 and S1PR4. S1P…
  • 2018 American Transplant Congress

    Ex Vivo Expanded Regulatory T Cells Combined with Short-Term Costimulation Blockade Prevent Rejection of Vascularized Composite Allografts

    B. Oh,1 G. Furtmüller,1 M. Grzelak,1 L. Vuong,2 M. Iglesias,1 M. Fryer,1 D. Cooney,1 W. Lee,1 G. Raimondi,1 G. Brandacher.1

    1Plastic and Reconstructive Surgery, Johns Hopkins SOM, Baltimore; 2Washington University in St. Louis SOM, St. Louis.

    [Background] Reconstructive transplantation represents a valid therapeutic option after devastating tissue loss. Routine clinical application, however, is hampered by the toxicity of long-term maintenance immunosuppression.…
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