ATC Abstracts

American Transplant Congress abstracts

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  • 2018 American Transplant Congress

    Implementing Mobile Health Technology for Living Kidney Donor Follow-Up: Transplant Provider Perspectives

    A. Eno,1 J. Ruck,1 S. Rasmussen,1 D. Segev,1,2 M. Henderson.1

    1Department of Surgery, Johns Hopkins School of Medicine, Baltimore; 2Department of Epidemiology, Johns Hopkins School of Public Health, Baltimore.

    Transplant hospitals are required to collect and report living kidney donor (LKD) follow-up data at 6-months, 1-year, and 2-years, but fewer than 50% of hospitals…
  • 2018 American Transplant Congress

    Biomaterial-Based Localized and Controlled Delivery of Tofacitinib to Actuate Enhanced Costimulation Blockade and Promote Long-Term Transplant Survival

    G. Raimondi,1 P. Majumder,2 V. Ivanova,1 X. Calderon-Colon,3 A. Mirdad,1 M. Iglesias Lozano,1 W. Lee,1 G. Brandacher,1 J. Schneider,2 J. Patrone.3

    1Johns Hopkins School of Medicine, Baltimore; 2National Cancer Institute, Frederick; 3Johns Hopkins Applied Physics Laboratory, Laurel.

    Complications from long-term use of calcineurin inhibitors remain a major issue for transplant patients and alternative therapies are highly needed. We investigated two innovative drug…
  • 2018 American Transplant Congress

    T Cell Immunomonitoring Including Donor Specific Treg Expansion Prospectively Predicts Renal Allograft Tolerance Induced by Transient Mixed Chimerism

    K. Hotta, T. Oura, A. Dehnadi, K. Huh, M. Matsunami, H. Sasaki, G. Benichou, J. Madsen, A. Cosimi, T. Kawai.

    Center for Transplant Science, Massachusetts General Hospital, Boston, MA.

    Background: Successful induction of allograft tolerance in MHC-mismatched kidney transplantation has been achieved after induction of transient chimerism in both nonhuman primates (NHP) and humans.…
  • 2018 American Transplant Congress

    NOS2 Deficiency Limits Long Term Survival of Murine Kidney Allografts

    I. Aljabban,1,2 B. Jiang,1 C. Yang,1 T. O'Shea,1 D. Ndishabandi,1 R. White,1 P. Russell,1 R. Colvin,1 J. Madsen,1 A. Alessandrini.1

    1Center for Transplantation Sciences, Massachusetts General Hospital, Boston, MA; 2Pennsylvania State University College of Medicine, Hershey, PA.

    Nitric oxide (NO) is a small molecule derived from L-arginine that governs a myriad of physiologic processes including the antimicrobial and tumoricidal responses. Although NO…
  • 2018 American Transplant Congress

    Reduction in Circulating CD19+CD24+CD27+ Regulatory B Cell Frequency Predicts Acute Rejection in Liver Transplant Patients

    H. Zhou, Z. Rao, Y. Lu, J. Rao, J. Gu, L. Lu, Y. Xia.

    Liver Transplant Center, First Affiliated Hospital of Nanjing Medical University, Nanjing, China.

    Background: Accumulating evidence suggests that regulatory B cells (Bregs) play an important role in modulating inflammation and autoimmune diseases. However, whether Bregs regulate acute liver…
  • 2018 American Transplant Congress

    Human Urine-Derived Stem Cells Protect Renal Function by Releasing miR-129-5p Which Targets High-Mobility Group Box-1 (HMGB1) in Rat Ischemia Reperfusion Injury Model

    L. Liu, X. Li, Q. Su, Z. Bi, H. Huang, C. Wang.

    Organ Transplant Center, The First Affiliated Hospital of Sun Yet-sen University, New York, NY, China.

    Objective: This study investigated the protective effect of human urine-derived stem cells (USCs) on renal ischemia reperfusion injury (IRI) in rats. Methods: Human USCs was…
  • 2018 American Transplant Congress

    Geographic Variation in the Treatment of Adult Heart Transplant Candidates in the US

    W. Parker,1 M. Churperk,1 D. Hedeker,1 E. Huang,1 E. Garrity,1 M. Siegler,1 A. Anderson.2

    1University of Chicago, Chicago, IL; 2Northwestern University, Chicago, IL.

    The current priority ranking system for US heart transplant candidates is based on treatment intensity which may encourage the overtreatment of relatively stable candidates. We…
  • 2018 American Transplant Congress

    Lymphocyte Proportions Post Thymectomy Are Associated with Allergic Disorders in Heart Transplanted Children

    T. Kim,1 L. Ionescu,1,2,3 N. Avdimiretz,4 M. Larsen,1,2,3 F. Murdoch,1,2 B. Motyka,1,2,3 S. Gilmour,1,2 L. West,1,2,3 S. Urschel.1,2,3

    1Pediatrics, University of Alberta, Edmonton, AB, Canada; 2Stollery Children's Hospital, Edmonton, AB, Canada; 3Alberta Transplant Institute, Edmonton, Canada; 4The Hospital for Sick Children, Toronto, Canada.

    Background: Allergic disorders are more common in pediatric heart transplant (HTx) recipients than non-transplanted children, with young age at HTx and thymectomy being risk factors.…
  • 2018 American Transplant Congress

    Combined Heart–Kidney Compared to Isolated Heart Transplant in Patients with Chronic Kidney Disease – A Single Center Experience

    D. Gauvin, A. Bhalla, W. McCallum, A. Vest, N. Goyal.

    Tufts University School of Medicine, Boston, MA.

    Background: Severe irreversible renal dysfunction has been a contraindication for heart transplant (HTx); however, combined heart-kidney transplant (HKTx) is an accepted therapeutic option for concomitant…
  • 2018 American Transplant Congress

    Analysis of Human Islet Damage during In Vitro Culture Using miRNA 375

    Y. Shindo,1 M. Levy,1,2 M. Kanak.1

    1Department of Surgery, School of Medicine, Virginia Commonwealth University, Richmond; 2Hume-Lee Transplant Center, VCU Health System, Richmond.

    BackgroundIslet culture prior to transplantation has been shown to facilitate recovery, reduce immunogenicity, suppress exocrine contamination and provides flexibility for evaluation of islets and preparation…
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