2018 American Transplant Congress
Kidney Allograft Vascular Disease Post-Transplant (KTX): Risk Factors and Implications
1Medicine, Mayo Clinic, Rochester, MN; 2Pathology, Mayo Clinic, Rochester, MN.
Background: Over time grafts develop arteriosclerosis (ART)and arteriolar hyalinosis (AH). Previous studies associated AH with calcineurin inhibitors (CNI), diabetes (DM), kidney age and hypertension. Other…2018 American Transplant Congress
Genomic Diversity of Epstein Barr Virus in Post-Transplant Lymphoproliferative Disorder
Purpose: In transplant recipients, Epstein-Barr Virus (EBV) is associated with the development of B cell lymphomas in post-transplant lymphoproliferative disorder (PTLD). We utilized next-generation sequencing…2018 American Transplant Congress
Identification of T Cells as Target of Intervention to Decrease Anti-LG3 Autoantibody Levels Prior to Transplantation
Research Centre, Centre Hospitalier de l'Université de Montréal (CRCHUM), Montreal, QC, Canada.
Autoantibodies against perlecan/LG3 fragment (anti-LG3) have been associated with accelerated allograft rejection and long-term renal allograft dysfunction. Intriguingly, anti-LG3 are present prior to transplantation in…2018 American Transplant Congress
A Novel Nomogram-Based Approach for Defining the Effect of Transplantation on Cancer Recurrence Risk
1U of Cincinnati, Cincinnati; 2Cleveland Clinic, Cleveland.
The effect of transplantation on renal cell cancer (RCC) recurrence risk has not yet been precisely defined. Validated nomograms for predicting RCC recurrence risk (viz,…2018 American Transplant Congress
An Individualized Strategy Using Virus and Immune-Based Markers to Prevent Cytomegalovirus Disease after Face Transplantation
Introduction: There is limited data on CMV prevention after face transplantation. We report an individualized approach using prophylaxis followed by surveillance and preemptive therapy guided…2018 American Transplant Congress
Rapamycin Impairs Human Endothelial Cell Alloimmunogenicity Independent of PD-1/PD-1 Ligand Inhibitory Signaling
Department of Surgery, Duke University Medical Center, Durham, NC.
Rapamycin prevents costimulation blockade (CoB)-resistant rejection in mice and primates, and early human data suggests a similar salutary effect. We have hypothesized that one mechanism…2018 American Transplant Congress
Predictors of Graft Survival at the Time of a Kidney Transplant Indication Biopsy
We predicted kidney transplant graft survival after indication biopsy in 884 patients. Analysis was performed using random forests, a multivariate machine learning method to assess…2018 American Transplant Congress
Prevention of New Onset Diabetes after Transplantation Using Bariatric Surgery
Transplant Surgery, University of Cincinnati, Cincinnati, OH.
New onset diabetes after transplantation (NODAT) is a common complication, occurring 20-36% after renal transplant historically and 15.8% at our institution. Obesity is a known…2018 American Transplant Congress
Health and Economic Disparities in Waitlist Access and Liver Distribution Policy
1Surgery, Emory University, Atlanta, GA; 2Hepatology, University of Pennsylvania, Philadelphia, PA.
Background:Sociodemographic disparities compound mortality on the liver transplant waitlist, but the relevance of waitlist disparities to mortality and access among the general population remains unclear.Methods:…2018 American Transplant Congress
Demographic and Geographic Differences in the Proportion of Liver Disease Deaths Captured by the Transplant Waitlist in the United States, 2011 – 2015
Background: There are no population-based estimates of the prevalence of end-stage liver disease in the United States, creating challenges in measuring disease burden to inform…
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