Am J Transplant, Volume 18, Suppl 3 Archives - Page 54 of 211 - ATC Abstracts

2018 American Transplant Congress
Everolimus with Reduced-Dose Calcineurin Inhibitor versus Mycophenolate with Standard-Dose Calcineurin Inhibitor in De Novo Kidney Transplant Recipients: Renal Function Results from the TRANSFORM Study
F. Oppenheimer,¹ C. Legendre,¹ J. Cruzado,¹ G. Russ,¹ O. Viklicky,¹ R. Oberbauer,¹ V. Garcia,¹ O. Witzke,¹ D. Kuypers,¹ R. Danguilan,¹ P. Bernhardt,² C. Sommerer.¹
¹TRANSFORM Study Group, Barcelona, Spain; ²Novartis Pharma AG, Basel, Switzerland.
Purpose: TRANSFORM (NCT01950819) is the largest study conducted in de novo kidney transplant recipients (KTxRs) to evaluate the benefit of everolimus with reduced-dose calcineurin inhibitor…
2018 American Transplant Congress
The Altruistic Living Kidney Donor Phenotype – From Inquiry to Donation
V. Kumar, P. MacLennan, M. Bonventre, M. Hanaway, R. Reed, J. Locke.
University of Alabama at Birmingham, Birmingham.
BackgroundWe distinguish an altruistic donor from the traditional living donor when a living person's offer to donate an organ is to “anyone” and not attached…
2018 American Transplant Congress
Safety of Antithymocyte Globulin Use in Donation after Circulatory Death (DCD) Liver Transplantation
D. Felix,¹ B. Geiger,¹ J. Descourouez,¹ M. Jorgenson,¹ B. Hanlon,² G. Leverson,² D. Foley.²
¹Department of Pharmacy, UW Health, Madison, WI; ²Department of Surgery, University of Wisconsin School of Medicine and Public Health, Madison, WI.
Purpose: Rabbit antithymocyte globulin (rATG) is commonly used for induction immunosuppression and treatment of rejection in solid organ transplantation. Previous work has shown that rATG…
2018 American Transplant Congress
Prospective Trial Using Pulmonary Rehabilitation to Treat Frailty
C. Kennedy,¹ P. Novotny,² E. Stevens,¹ J. Kirsch,³ J. Garrett,¹ N. LeBrasseur,⁴ R. Benzo.¹
¹Pulmonary and Critical Care Medicine, Mayo Clinic, Rochester, MN; ²Health Sciences Research, Mayo Clinic, Rochester, MN; ³Clinical and Health Psychology, University of FL, Gainesville, FL; ⁴Physical Medicine and Rehabilitation, Mayo Clinic, Rochester, MN.
Background: Frailty is a novel risk factor to potential lung transplant candidates and recipients associated with excess morbidity and mortality. Limited data is available on…
2018 American Transplant Congress
Th17 and NK Responses Are Differentially Induced in Renal Allografts According to Recipient Murine Cytomegalovirus Dose and Strain
M. Shimamura,¹ M. Li,² S. Boddeda,¹ B. Chen,² Q. Zeng,¹ T. Schoeb,² V. Velazquez.¹
¹Center for Vaccines and Immunity and Dept. of Pediatric Infectious Diseases, The Research Institute at Nationwide Children's Hospital and The Ohio State University, Columbus, OH; ²Depts. of Pediatric Infectious Diseases, Pathology, and Genetics, University of Alabama at Birmingham, Birmingham, AL.
Purpose: To study the impact of cytomegalovirus (CMV) recipient positive (R+) serostatus upon renal allograft injury, murine CMV (MCMV) D+/R+ kidney transplants using recipients infected…
2018 American Transplant Congress
The Benefit of Higher KDPI Renal Transplantation over Waiting for a Better Offer
E. Grodstein,¹ J. Yang,² V. Nair,¹ E. Molmenti,¹ L. Teperman.¹
¹Transplant Institute, Northwell Health, Manhasset, NY; ²Department of Epidemiology, Northwell Health, Manhasset, NY.
Background: The kidney donor profile index (KDPI) helps discern kidney function. While recipients must consent for KDPI >85% kidneys, clinicians often decide whether to accept…
2018 American Transplant Congress
Prevalence of Frailty among Kidney Transplant Recipients in the United States
A. Thomas,¹ A. Shaffer,¹ H. Ying,¹ S. Norman,² D. Segev,¹ M. McAdams-DeMarco.¹
¹JHU, Baltimore; ²University of Michigan, Ann Arbor.
Frailty, a measure of physiologic reserve, increases the risk of delayed graft function, longer length of stay, early hospital readmission, immunosuppression intolerance, and mortality among…
2018 American Transplant Congress
Delayed Graft Function in Simultaneous Liver Kidney Transplantation
S. Weeks,¹ X. Luo,¹ S. Ottmann,¹ A. Gurakar,² F. Naqvi,² B. Philosophe,¹ A. Cameron,¹ N. Desai,¹ D. Segev,¹ J. Garonzik Wang.¹
¹Department of Surgery, Johns Hopkins School of Medicine, Baltimore, MD; ²Department of Medicine, Johns Hopkins School of Medicine, Baltimore, MD.
Purpose: Increased rates of delayed graft function (DGF) after simultaneous liver kidney (SLK) transplantation have been described, as well as inferior graft survival in patients…
2018 American Transplant Congress
Approaches to Prevention of Antibody Rebound after HLA Sensitization in a Mouse Model
I. Kim, G. Wu, N-.N. Chai, A. Klein, S. Jordan.
Comprehensive Transplant Center, Cedars-Sinai Medical Center, Los Angeles, CA.
Purpose: Control of donor specific antibodies (DSA) is critical for prevention of antibody mediated rejection (ABMR). Removal of DSAs with PLEX often results in significant…
2018 American Transplant Congress
Prevention and Reversal of Diabetes through Restoration of B and T Cell Regulation and Immune Homeostasis
K. Brayman,¹ P. Chhabra,¹ C. Wilson,² A. Marshall,² D. Moore.²
¹Surgery, University of Virginia, Charlottesville, VA; ²Pediatric Endocrinology, Vanderbilt University, Nashville, TN.
Goal: To determine the mechanisms by which IgM restores immune homeostasis in new-onset diabetic NOD mice.Methods: 1) 5wks old non-obese diabetic (NOD) mice received mouse…