2018 American Transplant Congress
Assessment of a Discharge Transplant Knowledge Quiz and Its Impact on Outcomes in Liver Transplant Recipients
Medical University of South Carolina, Charleston, SC.
The aim of this study is to determine if transplant quiz scores given prior to discharge were predictive of known patient risk factors and if…2018 American Transplant Congress
A Propensity Matched Survival Analysis: Do Simultaneous Liver-Lung Transplant Recipients Need a Liver?
1School of Medicine, Duke University, Durham, NC; 2Surgery, Duke University, Durham, NC.
Objective: There is debate whether simultaneous lung-liver transplant (LLT) long-term outcomes warrant allocation of two organs to a single recipient. We hypothesized that LLT recipients…2018 American Transplant Congress
Kidney Transplant Rejection is Associated with Robust and Prolonged Bioenergetic Reprogramming and Metabolic Maladaptation
Medicine, University of Alabama at Birmingham, Birmingham, AL.
Introduction: Metabolic plasticity and mitochondrial bioenergetic homeostasis are altered due to a organ ischemia. However, the impact of the alloimmune response on the allograft is…2018 American Transplant Congress
Donor Derived Renal Cell Carcinoma (RCC) Transmission Events 2008-2016: A Report of the OPTN Disease Transmission Advisory Committee (DTAC)
Background: RCC is the most common renal tumor reported to the OPTN and reviewed by DTAC for assessment of potential donor transmission. Organs with concern…2018 American Transplant Congress
Assessment and Validation of Potential Predictors of Non-Adherence in Contemporary Kidney Transplant Recipients
Medical University of South Carolina, Charleston, SC.
The aim of this study is to assess the associations between traditional proxies of medication non-adherence and graft outcomes in contemporary kidney transplant recipients (KTRs).Methods:…2018 American Transplant Congress
Impact of Elevated PSA, and Prostate Cancer in ESRD on Time to Transplant, and Survival
1University Hospitals of Cleveland, Cleveland, OH; 2Case Western Reserve University, Cleveland, OH.
Introduction: Despite concerns for over-diagnosis and over-treatment from prostate cancer screeening, transplant centers perform it. We studied effect of Elevated PSA, and Prostate cancer on…2018 American Transplant Congress
Combination Proteasome Inhibition and Anti-BAFF Therapy Permits Highly Sensitized Rhesus Kidney Transplantation
Duke Transplant Center, Duke University Medical Center, Durham, NC.
Purpose:HLA-sensitization is a significant immunologic barrier to successful kidney transplantation (KT). We have shown that proteasome inhibition (PI) in insolation reduces plasma cells (PCs), but…2018 American Transplant Congress
CTLA4-Ig and Bortezomib Successfully Reverses Established DSA Responses in Allograft-Sensitized Recipients
Background: Sensitized recipients have lower rates of transplantation and poorer outcomes. We and others have reported that the delayed administration of CTLA4-Ig can disrupt fully-established…2018 American Transplant Congress
Prolonged Cold Ischemia Storage of Renal Allografts Shifts DSA Specificity and Enchances Glomerular Injury
Immunology, Cleveland Clinic, Cleveland, OH.
Prolonged cold ischemia storage (CIS) of donor organs is a major risk factor for acute and chronic graft injury. The goal of this study was…2018 American Transplant Congress
Antibody-Verified Eplet Mismatches as Determinants of Premature Kidney Transplant Loss
Introduction: HLA matching at the epitope level offers new opportunities to identify compatible donors for transplant candidates. HLAMatchmaker deduces B-cell epitope ('eplets' in HLAMatchmaker) mismatches…
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