2018 American Transplant Congress
The Results of the PRISM (Prediction of Rejection In Sensitized Patient Blood SaMples) Trial with a Novel Bioassay
Surgery and Medicine, University of California San Francisco, San Francisco.
Background. kSORT, a 17 gene blood biomarker, has been retrospectively validated for detection of BPAR and immune quiescence in kidney tx. This is the first…2018 American Transplant Congress
The Likelihood of Re-Transplantation in Patients Undergoing Allograft Nephrectomy
Introduction: transplant nephrectomy (NX) is a known cause of allosensitisation after graft failure. As yet, there is no consensus for the management of the patient…2018 American Transplant Congress
Global Expression Profiles of miRNA and Expression Patterns and Localization of the miR-21 in One-Hour Biopsy Specimens of Human Kidney Tansplantation from Donors after Cardiac Death
Because of the global shortage of renal grafts, kidney transplantation (KTx) from donors after cardiac death (DCDs) is an alternative way of obtaining KTx from…2018 American Transplant Congress
Non-Invasive Imaging Modalities for Immune Monitoring of Vascularized Composite Allografts Using a Translational Large Animal Model
PurposeImmunological complications and skin rejection remains an obstacle in broadening the applicability of vascularized composite allotransplantation (VCA). Currently, diagnosis of rejection relies on skin biopsies…2018 American Transplant Congress
False-Positive Flow-Cytometric T Cell Crossmatch Associated with Blood Type Antigen Expressed on Lymphocytes in ABO Incompatible Kidney Transplantation
Background: Flow-cytometric T cell crossmatch (FTXM) uses live donor lymphocytes to detect anti-donor-human leukocyte antigen (HLA) IgG antibodies. Therefore, the results can be affected by…2018 American Transplant Congress
In Vivo and In Vitro PPAR-y Activation Decreases M1-Macrophage Polarization and Improves Liver Ischemia Reperfusion Injury
Background:M1-Macrophage polarization has been studied as a potential target to decrease inflammatory response in sepsis and inflammation-related diseases. Its role in the setting of inflammatory…2018 American Transplant Congress
Donor-Derived Cell-Free DNA Outperforms Serum Creatinine Changes for Identifying Kidney Transplant Rejection
Purpose: In the DART study, donor-derived cell-free DNA (dd-cfDNA) discriminated biopsy-based diagnosis of active rejection in kidney transplant patients but serum creatinine (sCr) level did…2018 American Transplant Congress
NK Cells in Allograft Kidney Biopsies during Rejection: Detection, Quantification, and Precise Localization Using Multiplex Immunofluorescence
Introduction: Among the complex cellular interplay engaged in renal rejection, recent transcriptomic analysis of renal biopsies has detected NK cell transcripts in the setting of…2018 American Transplant Congress
Urinary Chemokine CXCL-10 in Long Term Renal Transplant Patients Associates with Urinary Tract Infections and Microvascular Damage
Non-invasive biomarkers are needed to predict rejection post kidney transplantation. In the early transplant period, urinary CXCL-9 and CXCL-10 associate with rejection. We assessed the…2018 American Transplant Congress
Kidney Transplantation in ESKD Patients with a History of Sickle Cell Disease/Trait
Introduction:Kidney transplantation in Sickle Cell Disease patients is fraught with complications, including increased risk of infection and thrombosis. We present long term outcomes of patients…
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