ATC Abstracts

American Transplant Congress abstracts

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  • 2018 American Transplant Congress

    The Results of the PRISM (Prediction of Rejection In Sensitized Patient Blood SaMples) Trial with a Novel Bioassay

    F. Vincenti, A. Schroeder, S.-C. Hseish, J. Liberto, P. Towfighi, C. Koh, T. Sigdel, M. Sarwal.

    Surgery and Medicine, University of California San Francisco, San Francisco.

    Background. kSORT, a 17 gene blood biomarker, has been retrospectively validated for detection of BPAR and immune quiescence in kidney tx. This is the first…
  • 2018 American Transplant Congress

    The Likelihood of Re-Transplantation in Patients Undergoing Allograft Nephrectomy

    G. Lucisano,1 P. Brookes,2 E. Santos-Nunez,2 N. Firmin,2 N. Gunby,2 S. Hassan,1 A. Gueret-Wardle,1 M. Willicombe,1 D. Taube.1

    1Renal and Transplant Centre, Imperial College Healthcare NHS Trust, London, United Kingdom; 2Histocompatibility and Immunogenetics, Imperial College Healthcare NHS Trust, London, United Kingdom.

    Introduction: transplant nephrectomy (NX) is a known cause of allosensitisation after graft failure. As yet, there is no consensus for the management of the patient…
  • 2018 American Transplant Congress

    Global Expression Profiles of miRNA and Expression Patterns and Localization of the miR-21 in One-Hour Biopsy Specimens of Human Kidney Tansplantation from Donors after Cardiac Death

    M. Kusaka,1 N. Fukami,1 H. Sasaki,1 A. Kawai,1 T. Kenmochi,2 T. Ito,2 R. Shiroki,1 K. Hoshinaga.1

    1Urology, Fujita-Health University, Toyoake/Aichi, Japan; 2Transplant Surgery, Fujita-Health University, Toyoake/Aichi, Japan.

    Because of the global shortage of renal grafts, kidney transplantation (KTx) from donors after cardiac death (DCDs) is an alternative way of obtaining KTx from…
  • 2018 American Transplant Congress

    Non-Invasive Imaging Modalities for Immune Monitoring of Vascularized Composite Allografts Using a Translational Large Animal Model

    J. Etra,1 K. Cilwa,2 G. Furtmueller,1 A. Leto Barone,1 K. Kolegraff,1 E. Elster,1 W. Lee,1 G. Brandacher.1

    1Department of Plastic Surgery, Johns Hopkins University School of Medicine, Baltimore, MD; 2Naval Medical Research Center, Silver Springs, MD; 3Department of Surgery, Uniformed Services, University of Health Sciences and Walter Reed National Military Medical Center, Bethesda, MD.

    PurposeImmunological complications and skin rejection remains an obstacle in broadening the applicability of vascularized composite allotransplantation (VCA). Currently, diagnosis of rejection relies on skin biopsies…
  • 2018 American Transplant Congress

    False-Positive Flow-Cytometric T Cell Crossmatch Associated with Blood Type Antigen Expressed on Lymphocytes in ABO Incompatible Kidney Transplantation

    D. Iwami,1 M. Ito,2 K. Hotta,1 H. Higuchi,1 N. Shinohara.1

    1Renal and Genitourinary Surgery, Hokkaido University, Graduate School of Medicine, Sapporo, Japan; 2Division of Laboratory and Transfusion Medicine, Hokkaido University Hospital, Sapporo, Japan.

    Background: Flow-cytometric T cell crossmatch (FTXM) uses live donor lymphocytes to detect anti-donor-human leukocyte antigen (HLA) IgG antibodies. Therefore, the results can be affected by…
  • 2018 American Transplant Congress

    In Vivo and In Vitro PPAR-y Activation Decreases M1-Macrophage Polarization and Improves Liver Ischemia Reperfusion Injury

    I. Linares,1 A. Bartczak,1 K. Farrokhi,1 D. Kollmann,1 M. Kaths,1 M. Hamar,1 P. Urbanellis,1 S. Ganesh,1 O. Adeyi,2 P. Yip,3 M. Selzner,1 N. Selzner.1

    1Multi Organ Transplant Program, Toronto General Hospital, Toronto, ON, Canada; 2Department of Pathology, Toronto General Hospital, Toronto, ON, Canada; 3Laboratory of Medicine and Pathobiology, Toronto General Hospital, Toronto, ON, Canada.

    Background:M1-Macrophage polarization has been studied as a potential target to decrease inflammatory response in sepsis and inflammation-related diseases. Its role in the setting of inflammatory…
  • 2018 American Transplant Congress

    Donor-Derived Cell-Free DNA Outperforms Serum Creatinine Changes for Identifying Kidney Transplant Rejection

    M. Weir,1 D. Hiller,2 J. Yee,2 A. Matas.3

    1University of Maryland School of Medicine, Baltimore, MD; 2CareDx, Brisbane, CA; 3University of Minnesota School of Medicine, Minneapolis, MN.

    Purpose: In the DART study, donor-derived cell-free DNA (dd-cfDNA) discriminated biopsy-based diagnosis of active rejection in kidney transplant patients but serum creatinine (sCr) level did…
  • 2018 American Transplant Congress

    NK Cells in Allograft Kidney Biopsies during Rejection: Detection, Quantification, and Precise Localization Using Multiplex Immunofluorescence

    M. Terada,1 J. Duong Van Huyen,2 F. Drieux,4 C. Legendre,3 P. Bruneval,1 M. Rabant.2

    1Pathology Department, Georges Pompidou European Hospital, Paris, France; 2Pathology Department, Necker-Enfants Malades Hospital, Paris, France; 3Kidney Transplantation Department, Necker-Enfants Malades Hospital, Paris, France; 4Pathology Department, Centre Henri Becquerel, Rouen, France.

    Introduction: Among the complex cellular interplay engaged in renal rejection, recent transcriptomic analysis of renal biopsies has detected NK cell transcripts in the setting of…
  • 2018 American Transplant Congress

    Urinary Chemokine CXCL-10 in Long Term Renal Transplant Patients Associates with Urinary Tract Infections and Microvascular Damage

    G. Irish,1,2 M. Hockley,1,2 S. Kireta,1,2 J. Johnson,1,2 R. Carroll.1,2

    1Central and Northern Adelaide Renal and Transplantation Service, Royal Adelaide Hospital, Adelaide, South Australia, Australia; 2The Faculty of Health and Medical Sciences, The University of Adelaide, Adelaide, South Australia, Australia.

    Non-invasive biomarkers are needed to predict rejection post kidney transplantation. In the early transplant period, urinary CXCL-9 and CXCL-10 associate with rejection. We assessed the…
  • 2018 American Transplant Congress

    Kidney Transplantation in ESKD Patients with a History of Sickle Cell Disease/Trait

    A. Lee, G. Malat, M. Harhay, L. Levin, G. Xiao, S. Guy, D. Reich, K. Ranganna.

    Department of Medicine, Division of Nephrology & Hypertension, Drexel University College of Medicine, Philadelphia, PA.

    Introduction:Kidney transplantation in Sickle Cell Disease patients is fraught with complications, including increased risk of infection and thrombosis. We present long term outcomes of patients…
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