Am J Transplant, Volume 18, Suppl 3 Archives - Page 5 of 211 - ATC Abstracts

2018 American Transplant Congress
Intragraft MicroRNAs Foretell Fibrosis in Kidney Transplant Recipients
H. Yang,¹ L. Amrouche,² K. Akat,³ C. Li,¹ Z. Khan,¹ C. Tinel,² T. Tuschl,³ D. Anglicheau,² T. Muthukumar.¹
¹Weill Cornell Medicine, New York; ²Hôpital Necker, Paris, France; ³Rockefeller University, New York.
BackgroundIdentifying biomarkers that anticipate tubulointerstitial fibrosis (IFTA) of the kidney allograft will be a transformative advance.Aim/HypothesisIntragraft microRNA profile of 3-month surveillance biopsies reported as normal…
2018 American Transplant Congress
Clinical Significance and Therapeutic Potential of Orosomucoid 1 for Chronic Active Antibody Mediated Rejection in Kidney Transplant Recipients
H. Higuchi,^1,2 K. Hotta,¹ D. Iwami,¹ J-.J. Jiang,² D. Kamimura,² Y. Arima,² T. Atsumi,² Y. Takada,^1,2 H. Harada,³ M. Murakami,² N. Shinohara.¹
¹Department of Renal and Genitourinary Surgery, Graduate School of Medicine, Hokkaido University, Sapporo, Hokkaido, Japan; ²Division of Molecular Psychoimmunology, Institute for Genetic Medicine and Graduate School of Medicine, Hokkaido University, Sapporo, Hokkaido, Japan; ³Department of Kidney Transplant Surgery, Sapporo City General Hospital, Sapporo, Hokkaido, Japan.
［Background］We reported a molecular mechanism to develop chronic inflammation (CI), called the inflammation amplifier (IA). IA is activated by concomitant activation of NFkB and STAT3…
2018 American Transplant Congress
Long-Term HIF-1α Stabilization is Associated with Fibrosis in Rat Lung Allografts
K. Freischlag,¹ B. Ezekian,¹ P. Schroder,¹ J. Everitt,¹ J. Yoon,¹ M. Swiderska-Syn,³ W. Parker,¹ A. Diehl,¹ J. Kwun,¹ S. Knechtle.¹
¹Duke Transplant Center, Duke University, Durham, NC; ²Medical University of South Carolina, Charleston, SC.
Introduction: HIF-1α is a subunit of a heterodimeric transcription factor hypoxia-inducible factor 1 (HIF-1) and functions as a master transcriptional regulator of cellular and developmental…
2018 American Transplant Congress
Association of CYP3A5*3*6*7 Metabolic Composites to Tacrolimus Pharmacokinetics in African American and Caucasian Renal Transplant Recipients
K. Tornatore,^1,5 D. Brazeau,² C. Meaney,¹ K. Attwood,^3,4 G. Wilding,⁴ S. Chang,⁵ R. Venuto.⁵
¹Pharmacy, School of Pharmacy, University at Buffalo(UB), Buffalo; ²Pharmaceutical Sciences, College of Pharmacy; University of New England, Portland; ³Biostatistics, Roswell Park Cancer Institute, Buffalo; ⁴Biostatistics, UB School of Public Health, Buffalo; ⁵Nephrology, UB School of Medicine, Buffalo.
Background: Interpatient variability in tacrolimus pharmacokinetics(PK) is due primarily to metabolism by cytochrome P-450 3A5(CYP3A5) isoenzymes. African Americans(AA) require higher tacrolimus doses to achieve comparable…
2018 American Transplant Congress
In Vivo Allograft Exposure to Mitochondrial DAMPs Prior to Organ Procurement Increases Graft Rejection in Mice
L. Lin, J. Wang, L. Cendales, A. Kirk, T. Brennan.
Surgery, Duke University, Durham, NC.
Mitochondria released in the setting of tissue injury are a source of damage associated molecular patterns (DAMPs) that initiate innate immune responses. We hypothesized that…
2018 American Transplant Congress
CXCR4 Inhibition Improves Donor Leukocyte Depletion during Ex Vivo Lung Perfusion
R. Davis, Q. Gao, J. Yerxa, M. Daneshmand, J. Haney, J. Klapper, M. Hartwig, A. Barbas.
Surgery, Duke University, Durham, NC.
Background: Ex vivo lung perfusion (EVLP) has emerged as a modern preservation technique, developed to evaluate candidate donor lungs in a normothermic and metabolically active…
2018 American Transplant Congress
Molecular Monitoring for Kidney Allograft Injury Following HLA Incompatible Transplantation
A. Jackson,¹ B. Iglehart,¹ S. Bagnasco,³ N. Desai.²
¹Medicine, Johns Hopkins University, Baltimore, MD; ²Surgery, Johns Hopkins University, Baltimore, MD; ³Pathology, Johns Hopkins University, Baltimore, MD.
Elevated donor derived cell free DNA (ddcfDNA) has been shown to correlate with allograft rejection following heart, lung, and kidney transplantation. We investigated whether sequential…
2018 American Transplant Congress
Diagnostic Usefulness of Medullary C4d Staining in Renal Allografts
J. Von Visger,¹ C. Von Visger, A. Satoskar,² T. Nadasdy,² J. Hemminger,² S. Brodsky.²
¹Medicine, The Ohio State University Wexner Medical Center, Columbus, OH; ²Pathology, The Ohio State University Wexner Medical Center, Columbus, OH.
Background: Detection of peritubular capillary (PTC) complement C4d on renal allograft biopsy is a histologic marker (along with serum anti-donor antibody, PTC inflammatory cells and…
2018 American Transplant Congress
Noninvasive Detection of Infection and Rejection in Renal Transplant Patients
Y. Zhou,¹ Y. Cheng,¹ T. Chiang,² G. Yang,² X. Li,² F. Zeng,² X. Wang,¹ J. Ge,² X. Hu,² H. Shi,¹ T. Wang,² L. Liu.³
¹Laboratory of Transplant Genomics, Jiangsu University Institute of Life Science, ZhenJiang, JingSu, China; ²Reasearch and Development Dpartment, SuZhou RRGene.Co.Ltd., SuZhou, JiangSu, China; ³Department of Urological Organ Transplantation, The Second XiangYa Hospital of Center South University, ChangSha, Hunan, China.
About 35% of patients would suffer actue rejection or infectionin in two years after reanl trandplantation.Cell-free DNA (cfDNA) is a new biomarker to evluate health…
2018 American Transplant Congress
The Results of Plasmapheresis and Anti-CD20 Based Desensitization without Intravenous Immunoglobulin in Positive Crossmatch Kidney Transplants
H. Kwon, Y. KIm, J. Choi, S. Shin, J. Jung, M. Cho, J. Kim, D. Han.
Asan Medical Center, Seoul, Korea.
This study examined the mid-term clinical outcomes in positive crossmatch kidney transplants (XMKT) for patients who received desensitization with plasmapheresis (PP) and anti-CD20 based regimens…

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