Am J Transplant, Volume 18, Suppl 3 Archives - Page 49 of 211 - ATC Abstracts

2018 American Transplant Congress
Digital-Enabled Refills and Medication Adherence among Transplant Recipients
S. Boghani, H. Kirkham, G. Pietradoni, N. Hira.
Walgreen Co., Deerfield, IL.
Purpose: Impact of nonadherence among transplant recipients has been well documented as a significant contributor of allograft failure. The objective of this study was to…
2018 American Transplant Congress
Enhancement of Intrinsic Apoptosis via Bcl-2 Inhibition Promotes Induction of Robust Mixed Chimerism and Renal Allograft Tolerance without Myelosuppression in Nonhuman Primates
T. Oura,¹ A. Dehnadi,¹ I. Rosales,¹ H. Sasaki,¹ P. Cippa,² R. Fehr,² A. Cosimi,¹ T. Kawai.¹
¹Surgery, Center for Transplantation Science, Massachusetts General Hospital, Boston, MA; ²Medicine, University of Zurich, Zurich, Switzerland.
Background: Successful induction of mixed chimerism (MC) and renal allograft tolerance has been achieved in both nonhuman primate (NHP) and man following conditioning that included…
2018 American Transplant Congress
CD40 Signaling in Proximal Tubules Regulates Fibrosis in Both Hypertension and Chronic Allograft Rejection
V. Bletsos, J. Breidenbach, S. Haller, S. Stepkowski.
University of Toledo College of Medicine and Life Sciences, Toledo, OH.
Background: We explored the role of CD40 signaling in kidney proximal tubule epithelial cells on renal interstitial fibrosis (IF) in two models: hypertension; and chronic…
2018 American Transplant Congress
Optimizing Outcomes with a Collaborative Approach after Kidney Transplant in Hepatitis C-Positive Recipients Receiving Hepatitis C-Positive Grafts
A. Ray, R. Rubin, T. Ommert, R. Cross, C. Klein.
Piedmont Transplant Institute, Piedmont Healthcare, Atlanta, GA.
PURPOSE: To evaluate the multidisciplinary approach to HCV treatment in HCV+ kidney recipients receiving HCV+ grafts. METHODS: Single center review of treatment and outcomes in…
2018 American Transplant Congress
The First 9 Years of KPD through the National Kidney Registry: Characteristics of Donors and Recipients Compared to National Transplant Registries
S. Flechner,¹ A. Thomas,² M. Ronin,³ J. Veale,⁴ D. Leeser,⁵ S. Kapur,⁶ J. Piepert,⁴ D. Segev,² G. Hil,³ A. Waterman.⁴
¹Cleveland Clinic, Cleveland, OH; ²Johns Hopkins, Baltimore, MD; ³National Kidney Registry, Babylon, NY; ⁴UCLA, Los Angeles, CA; ⁵East Carolina, Greenville, NC; ⁶Cornell, New York, NY.
Purpose: The NKR is a voluntary network of 75 transplant centers in 28 States in the USA focused on the facilitation of live donor kidney…
2018 American Transplant Congress
Intragraft Gene Expression Differentiates Polyomavirus Nephropathy from T-Cell Mediated Rejection
B. Adam,¹ S. Wagner,¹ J. Bräsen,² V. Bröcker,² V. D'Agati,³ C. Drachenberg,⁴ E. Farkash,⁵ A. Farris,⁶ L. Geldenhuys,⁷ A. Magil,⁸ V. Nickeleit,⁹ P. Randhawa,¹⁰ H. Regele,¹¹ M. Mengel.¹
¹University of Alberta, Edmonton, Canada; ²Hannover Medical School, Hannover, Germany; ³Columbia University, New York; ⁴University of Maryland, College Park; ⁵University of Michigan, Ann Arbor; ⁶Emory University, Atlanta; ⁷Dalhousie University, Halifax, Canada; ⁸University of British Columbia, Vancouver, Canada; ⁹University of North Carolina, Chapel Hill; ¹⁰University of Pittsburgh, Pittsburgh; ¹¹Medical University of Vienna, Vienna, Austria.
Background: Improved immunosuppression protocols have reduced the incidence of T-cell mediated rejection (TCMR) but still carry a significant risk of BK polyomavirus nephropathy (BKVN). Despite…
2018 American Transplant Congress
Significant Alteration in Transplant Center Performance Assessment with Extended Patient Follow Up Time
J. Schold, D. Goldfarb, S. Flechner, A. Wee, E. Poggio.
Cleveland Clinic, Cleveland.
IntroductionCurrent transplant center performance models focus on 1-year graft and patient survival as primary outcomes. This is despite that 2.5 year cohorts are used to…
2018 American Transplant Congress
Altered Function of Cytomegalovirus Specific T Cells in Transplant Recipients
L. Higdon,¹ J. Trofe-Clark,² S. Liu,¹ N. Saligrama,¹ K. Margulies,² M. Davis,¹ J. Maltzman.^1,3
¹Stanford U, Stanford, CA; ²U Pennsylvania, Philadelphia, PA; ³VA Palo Alto, Palo Alto, CA.
Background: Cytomegalovirus (CMV) reactivation is associated with increased morbidity and mortality in transplant recipients. CMV establishes latency for the host's lifetime and frequently reactivates. Immunosuppression,…
2018 American Transplant Congress
Presence of Donor Specific Antibodies is Associated with Accelerated Podocyte Detachment
A. Naik, J. Aqeel, D. Cibrik, M. Samaniego, S. Wang, M. Chowdhury, F. Afshinnia, R. Wiggins.
University of Michigan, Ann Arbor; University of Kansas, Kansas City.
Introduction: Both indication and 10-yr surveillance biopsy data point to the important role of progressive glomerular disease in intermediate and long-term allograft outcomes. As all…
2018 American Transplant Congress
A Phase-I Clinical Trial of Donor-Derived MIC Cell Infusion for the Induction of Donor-Specific Hyporesponsiveness after Living Donor Kidney Transplantation (TOL-1 Study)
C. Morath,¹ A. Schmitt,² C. Kleist,³ V. Daniel,³ G. Opelz,³ C. Süsal,³ F. Fälble,¹ C. Sommerer,¹ L. Wang,² M. Zeier,¹ M. Schmitt,² M. Schaier,¹ P. Terness.³
¹Nephrology, University of Heidelberg, Heidelberg, Germany; ²Hematology, University of Heidelberg, Heidelberg, Germany; ³Transplant Immunology, University of Heidelberg, Heidelberg, Germany.
MIC cells are donor-derived monocytes that gain immunosuppressive properties after incubation with the proliferation inhibitor mitomycin C.PBMCs were harvested from living donors by leukapheresis and…