Am J Transplant, Volume 18, Suppl 3 Archives - Page 47 of 211 - ATC Abstracts

2018 American Transplant Congress
Characterization of Renal Allograft Tolerance Induction via Transient Mixed Chimerism in Non-Human Primates
H. Sasaki,¹ C. Thaiss,¹ T. Oura,¹ A. Rosales,² R. Smith,² R. Colvin,² B. Cosimi,¹ T. Kawai.¹
¹Surgery, Center for Transplantation Sciences, Massachusetts General Hospital, Boston; ²Pathology, Massachusetts General Hospital, Boston.
Background: We have previously reported long-term renal allograft tolerance after induction of transient mixed chimerism in non-human primates. However, some recipients developed late onset chronic…
2018 American Transplant Congress
The Role of pDCs in Formation of Treg-Rich Organized Lymphoid Structures in Spontaneously Accepted Murine Kidney Allografts is Dependent on Mismatching of MHC Class II Molecules at the H2-I-A^b Locus
T. O'Shea,^1,2 C. Yang,¹ I. Rosales,² N. Oh,¹ D. Ndishibandi,^1,2 T. Ashry,¹ P. Russell,¹ J. Madsen,¹ R. Colvin,² A. Alessandrini.^1,2
¹Center for Transplantation Sciences, Department of Surgery, Massachusetts General Hospital, Boston, MA; ²Department of Pathology, Massachusetts General Hospital, Boston, MA.
Introduction: Our lab has demonstrated that murine kidney allografts are spontaneously accepted in specific donor-recipient strain combinations. Histologic examination of spontaneously accepted DBA/2J (DBA) kidneys…
2018 American Transplant Congress
Ex-Vivo Generation of Alloantigen-Specific Immunomodulatory Cells: Elucidating the Mechanistical Synergy of Cell Components
M. Yao,¹ M. Kumagai-Braesch,¹ M. Watanabe,^1,2 K. Tokodai,¹ T. Lundgren,¹ M. Uhlin,¹ B. Ericzon.¹
¹Department of Transplantation Surgery, Karolinska University Hospital, Stockholm, Sweden; ²Transplantation, Hokkaido University Hospital, Sapporo, Japan.
IntroductionRecently, Todo et al. reported that ex-vivo generated immunomodulatory cells induced operational tolerance in 7/10 liver transplanted recipients. To allow wide spread application, it is…
2018 American Transplant Congress
Metabolic Regulation of Neuropeptides Induces Weight Loss and is Linked to Prolongation of Allograft Survival
M. Quante,^1,2 T. Heinbokel,¹ K. Minami,¹ Y. Nian,¹ A. Elkhal,¹ S. Tullius.¹
¹Transplant Surgery Research Lab, Brigham and Women's Hospital, Boston, MA; ²Department of General, Visceral and Transplant Surgery, Tuebingen Unversity Hospital, Tuebingen, Germany.
Obesity has become a common comorbidity among transplant recipients that is linked to inferior transplant outcome through far-reaching effects on metabolism, inflammation and immunity. Increasingly,…
2018 American Transplant Congress
A Proteomic Analysis of Kidneys Subjected to Normothermic Ex Vivo Kidney Perfusion (NEVKP) Demonstrates That Metabolism is an Important Determinant of Kidney Function Following Warm Ischemia
A. Konvalinka,^1,4 T. Tokar,² S. Reid,⁴ P. Urbanellis,⁴ M. Hamar,⁴ M. Kaths,⁴ I. Jurisica,² L. Robinson,^4,3 M. Selzner.^4,5
¹Medicine/Nephrology, University Health Network, Toronto, ON, Canada; ²Medical Biophysics/Computer Science, University of Toronto, Toronto, ON, Canada; ³Pediatrics/Nephrology, Hospital for Sick Children, Toronto, ON, Canada; ⁴Institute of Medical Science, University of Toronto, Toronto, ON, Canada; ⁵Surgery/General Surgery, University Health Network, Toronto, ON, Canada.
Kidney transplantation reduces mortality compared to staying on dialysis, incentivizing the use of marginal kidneys in face of organ shortage. These marginal kidneys after cardiocirculatory…
2018 American Transplant Congress
Amiodarone Use Increases Morbidity Not Mortality in Pediatric Heart Transplant Recipients
S. Amdani, A. Dalal, K. Simpson, J. Scheel, A. Abarbanell, P. Eghtesady, C. Canter, C. Castleberry.
Pediatric Cardiology, St.Louis Children's Hospital, St. Louis, MO.
Background: Amiodarone is commonly used in pediatric and adult patients with end-stage heart failure and its use is associated with increased 1-year post-transplant mortality in…
2018 American Transplant Congress
Chronic Narcotic Use Increases Mortality Rates in Heart Transplantation
G. St. John, T. Chamogeorgakis, H. Nemeh, C. Tita, Y. Selektor, D. Lanfear, C. Williams.
Transplant, Henry Ford Hospital, Detroit, MI.
Purpose: In kidney and liver transplantation, chronic narcotic use pre and post-transplant has been associated with an increased risk for rejection and early graft loss.…
2018 American Transplant Congress
IVIG Induction May Be Helpful in Highly Sensitized Patients after Heart Transplantation
J. Patel, M. Kittleson, E. Kransdorf, R. Levine, S. Dimbil, D. Geft, D. Chang, L. Czer, J. Kobashigawa.
Cedars Sinai Medical Center, Los Angeles.
Purpose: Strategies for sensitized patients undergoing heart transplant include post-op anti-thymocyte globulin (ATG) induction therapy as well as intravenous immunoglobulin (IVIG). We sought to assess…
2018 American Transplant Congress
Assessing Renal Transplant Candidate Survival at Listing Using a Risk-Adjusted Multi-State Semi-Markov Model
S. Mehrotra,¹ V. Kilambi.²
¹Industrial Engineering, Northwestern University, Evanston, IL; ²RAND Corporation, Boston, MA.
Newly listed candidates for kidney transplant must navigate several processes over the course of their treatment. Of special interest to such candidates is their expected…
2018 American Transplant Congress
Race and Socioeconomic Disparities in Organ Type, Recovery and Readmission in Kidney Transplant Recipients
A. Crane, T. Coy, N. Yerram, M. Eltemamy, E. Poggio, R. Fatica, A. Wee, C. Modlin, V. Krishnamurthi.
Glickman Urology and Nephrology, Cleveland Clinic, Cleveland.
Objectives: Racial and socioeconomic disparities are prevalent in healthcare, including for kidney transplant recipients. Post-transplant, patients are faced with many challenges that contribute to high…