Am J Transplant, Volume 18, Suppl 3 Archives - Page 46 of 211 - ATC Abstracts

2018 American Transplant Congress
Morphometric and Metabolic Correlates of Frailty in Pancreas Transplant Recipients
R. Parsons, J. Wolosyn, R. Lynch.
Surgery, Emory University, Atlanta, GA.
Background: Prediction of survival and health resource utilization in the pancreas transplant population requires novel approaches to risk stratification. We studied whether sarcopenia and osteopenia,…
2018 American Transplant Congress
A Novel Peripheral Blood mRNA Biomarker Predicts Subclinical Rejection and Kidney Transplant Outcomes
J. Friedewald,¹ S. Kurian,² T. Whisenant,² R. Heilman,³ E. Poggio,⁴ C. Marsh,² P. Baliga,⁵ N. Bridges,⁶ J. Odim,⁶ M. Brown,⁶ D. Ikle,⁷ B. Armstrong,⁷ J. Charette,¹ S. Brietigam,¹ N. Sustento-Reodica,¹ L. Zhao,¹ M. Kandpal,¹ D. Salomon,² M. Abecassis.¹
¹Northwestern Medicine, Chicago; ²Scripps, La Jolla; ³Mayo AZ, Scottsdale; ⁴Cleveland Clinic, Cleveland; ⁵MUSC, Charleston; ⁶NIAID, Bethesda; ⁷Rho, Chapel Hill.
BACKGROUNDSub-clinical acute rejection (subAR) in kidney transplant recipients (KTR), defined as histological rejection on surveillance biopsy (Bx) in a patient with stable renal function, signals…
2018 American Transplant Congress
Two Trajectories of Post-DSA eGFR after Kidney Transplant
J. Beaumont,¹ K. Briley,² A. Maldonado,³ C. Haisch,² P. Bolin,² S. Kendrick,⁴ H. Jones,⁴ K. McLawhorn,⁴ D. Leeser,² L. Rebellato,² M. Everly.¹
¹Terasaki Research Institute, Los Angeles, CA; ²East Carolina University, Greenville, NC; ³Vidant Medical Center, Greenville, NC; ⁴Eastern Nephrology Associates, Greenville, NC.
A clearer understanding of the patterns of glomerular filtration rate (GFR) decline following donor-specific antibody (DSA) development and the factors that might be associated with…
2018 American Transplant Congress
Meeting OPTN Requirements for Living Kidney Donation Follow-Up: Findings from the KDOC Study
J. Rodrigue,¹ C. Sokas,¹ A. Fleishman,¹ J. Schold,² P. Morrissey,³ J. Whiting,⁴ J. Vella,⁴ L. Kayler,⁵ D. Katz,⁶ J. Jones,⁶ B. Kaplan,⁷ M. Pavlakis,¹ D. Mandelbrot.⁸
¹Beth Israel Deaconess Medical Center, Boston; ²Cleveland Clinic, Cleveland; ³Rhode Island Hospital, Providence; ⁴Maine Medical Center, Portland; ⁵Erie County Medical Center, Buffalo; ⁶University of Iowa, Iowa City; ⁷Mayo Clinic, Scottsdale; ⁸University of Wisconsin, Madison.
The Organ Procurement and Transplantation Network (OPTN) requires programs to submit complete, accurate and timely clinical information for 80% and laboratory data for 70% of…
2018 American Transplant Congress
Influence of Initial Tumor Burden and Wait Times on Post-Transplant Outcomes after Down-Staging of Hepatocellular Carcinoma (HCC)
N. Mehta, J. Dodge, F. Yao.
UCSF, San Francisco.
Background: A new national policy has adopted the UNOS Region 5 down-staging protocol for liver transplant (LT) in HCC meeting the following inclusion criteria -…
2018 American Transplant Congress
OX40 Costimulation Prevents Induction of Foxp3⁺ Tregs through Upregulation of Novel Repressors of Foxp3 Gene Expression
X. Zhang,¹ X. Xiao,¹ P. Lan,¹ J. Li,¹ Y. Dou,¹ W. Chen,¹ N. Ishii,² S. Chen,¹ E. Taparowsky,³ X. Li.^1,4
¹Immunobiology & Transplant Research Center, Houston Methodist Hospital, Houston, TX; ²Department of Microbiology and Immunology, Tohoku University, Sendai, Japan; ³Department of Biological Sciences, Perdue University, Lafayette, IN; ⁴Department of Surgery, Weill Cornell Medical College of Cornell University, New York, NY.
Foxp3+ Tregs are essential for the induction of transplant tolerance and OX40 costimulation is known to break transplant tolerance. The exact mechanism of OX40 in…
2018 American Transplant Congress
The Cost Savings of Preemptive Kidney Transplantation
P. Dean,¹ H. Heien,² K. Swanson,² B. Borah,² L. Sangaralingham,² J. Naessens,² M. Stegall.¹
¹Division of Transplantation Surgery, Mayo Clinic, Rochester, MN; ²Robert D. and Patricia E. Kern Center for the Science of Health Care Delivery, Mayo Clinic, Rochester, MD.
Introduction: Preemptive kidney transplantation (PreKTx) is associated with improved patient survival and quality of life. The goal of this study was to compare the costs…
2018 American Transplant Congress
Identification of Macrophage Innate Receptors in Recognition and Rejection of Allogeneic Non-Self in Transplantation
P. Lan,¹ H. Dai,² W. Liu,¹ S. Chen,¹ L. Minze,¹ Y. Dou,¹ Y. Zhao,¹ W. Chen,¹ X. Xiao,¹ P. Pan,¹ H-.H. Chen,¹ F. Lakkis,² X. Li.¹
¹Immunobiology and Transplant Science Center, Houston Methodist Research Institute, Houston, TX; ²Starzl Transplantation Institute, University of Pittsburgh, Pittsburgh, PA.
Recent studies in several labs provide compelling evidence that the innate immune cells can recognize and reject allogeneic non-self in an antigen-specific manner, but the…
2018 American Transplant Congress
Non-Invasive Proteomics to Detect Biomarkers for Kidney Allograft Dysfunction
M. Watson,¹ M. Srivastava,³ D. Little,¹ O. Eidelman,³ R. Nee,¹ A. Bera,³ J. Karaian,³ D. Oliver,¹ H. Pollard,³ R. Jindal.²
¹Nephrology, USU-Walter Reed, Bethesda, MD; ²Surgery, USU-Walter Reed, Bethesda, MD; ³Anamtomy, Physiology and Genetics, USU-School of Medicine, Bethesda, MD.
Background: Non-invasive biomarkers are needed for monitoring patients to predict early acute rejection (AR). We hypothesized that protein biomarkers released from rejecting allograft tissues can…
2018 American Transplant Congress
Intragraft MicroRNA Transcriptome of Acute Antibody Mediated Rejection of Human Kidney Allografts
H. Yang,¹ K. Akat,² C. Li,¹ C. Snopkowski,¹ Z. Khan,¹ D. Dadhania,¹ T. Tuschl,² M. Suthanthiran,¹ T. Muthukumar.¹
¹Weill Cornell Medicine, New York; ²Rockefeller University, New York.
BackgroundMicroRNAs (miRNA) are master regulators of gene expression and are potential therapeutic targets. Intragraft miRNA transcriptome of acute antibody rejection (AMR) of human kidney allograft…