ATC Abstracts

American Transplant Congress abstracts

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  • 2018 American Transplant Congress

    Donor Derived Transmissions in 2016-2017: Analysis of the OPTN Ad Hoc Disease Transmission Advisory Committee (DTAC)

    C. Wolfe, S. Tlusty, G. Vece, R. Bag, G. Berry, J. Bucio, L. Danziger-Isakov, D. Florescu, D. Goldberg, C. Ho, R. La Hoz, K. Lilly, M. Malinis, A. Mehta, M. Nalesnik, R. Sawyer, L. Strasfeld, P. Wood, N. Theodoropoulos, M. Michaels.

    DTAC, United Network for Organ Sharing, Richmond, VA.

    The DTAC evaluates unanticipated potential donor-derived transmission events (PDDTE), including mostly infections (I) & malignancies (M), to assess for likelihood of donor transmission. Reporting policy…
  • 2018 American Transplant Congress

    Reducing No-Show Rate and Filling Cancelled Appointments: Multi-Faceted Interventions Markedly Reduced Time to Kidney Transplant Evaluation

    E. Gibney, K. Payne, C. Fowler.

    Piedmont Transplant Institute, Piedmont Atlanta Hospital, Atlanta, GA.

    Introduction: Time from referral to appointment for kidney transplant evaluation is an important metric. Demands of dialysis schedules and transportation logistics typically lead to high…
  • 2018 American Transplant Congress

    Everolimus with Reduced Calcineurin Inhibitor Exposure in De Novo Kidney Transplant Recipients: Efficacy and Safety Outcomes from the TRANSFORM Study

    S. Mulgaonkar,1 J. Pascual,1 S. Chadban,1 H. Tedesco,1 S. Berger,1 Y. Qazi,1 C. Legendre,1 N. Basic-Jukic,1 P. Bernhardt,2 F. Vincenti.1

    1TRANSFORM Study Group, Livingston; 2Novartis Pharma AG, Basel, Switzerland.

    Purpose: Everolimus (EVR)-facilitated calcineurin inhibitor (CNI) reduction regimens help prevent long-term CNI nephrotoxicity in kidney transplant recipients (KTxRs). TRANSFORM (NCT01950819) is the largest study in…
  • 2018 American Transplant Congress

    Circulating Follicular Helper T Cells (cTfh) in Renal Transplantation: Utility as Rejection Biomarker

    R. Laguna-Goya,1 A. Utrero-Rico,1 F. Cano-Romero,1 E. Gómez-Massa,2 D. Arroyo,1 P. Auñon-Rubio,3 A. Sevillano-Prieto,3 M. Castro-Panete,2 A. Andrés,3 E. Paz-Artal.1,2

    1Immunodeficiencies e Immunology Group, Research Institute of Hospital 12 de Octubre (i+12), Madrid, Spain; 2Immunology, Hospital 12 de Octubre, Madrid, Spain; 3Nephrology, Hospital 12 de Octubre, Madrid, Spain.

    Introduction: Antibody (Ab) mediated rejection is responsible for 30-50% of renal graft failures. Follicular helper T cells (Tfh) are required for the differentiation of B…
  • 2018 American Transplant Congress

    DNA Methylation Age and Differential Patterns of DNA Methylation in Older Compared with Younger Kidney Transplant Recipients

    J. Schaenman, X. Zhou, R. Guo, M. Rossetti, E. Liang, B. Abdalla, E. Lum, S. Bunnapradist, G. Danovitch, E. Reed, D. Elashoff.

    David Geffen School of Medicine at UCLA, Los Angeles, CA.

    Introduction: Older transplant recipients experience increased rates of infection and death, but decreased rates of rejection, suggesting a role of immune dysfunction. Analysis of DNA…
  • 2018 American Transplant Congress

    AT1R Antibody Analysis: High Proportion of Non-Specific Reactivity?

    A. Halpin,1,3,4,5 S. Abou-Zeki,3 I. Larsen,1,4 P. Campbell,2,3,4,5 S. Urschel,1,4,5 L. West.1,3,4,5

    1Dept of Pediatrics, U of Alberta, Edmonton, Canada; 2Dept of Medicine, U of Alberta, Edmonton, Canada; 3Dept of Lab Medicine & Pathology, U of Alberta, Edmonton, Canada; 4ATI, , Canada; 5CNTRP, , Canada.

    INTRODUCTION:The angiotensin II type 1 receptor (AT1R) is expressed on vascular endothelium. AT1R antibodies (Ab) have been studied to examine their relevance in renal and…
  • 2018 American Transplant Congress

    Whole-Transcriptome Sequencing to Identify Macaque Immune Gene Variants

    A. Haj,1 J. Karl,1 R. Wiseman,1 D. O'Connor.1,2

    1Department of Pathology and Laboratory Medicine, University of Wisconsin, Madison, WI; 2Wisconsin National Primate Research Center, Madison, WI.

    Macaque monkeys are critical in transplantation studies, yet macaque genomics lags significantly behind human genomics. While reliable genotyping methods have been developed for some macaque…
  • 2018 American Transplant Congress

    Soluble Fibrinogen-Like Protein 2 Regulates Myeloid-Derived Suppressor Cells Differentiation and Enhances Its Immunosuppressive Function of in Allograft Immunity

    C. Yang, T. Zhu.

    Urology, Zhongshan Hospital, Fudan University, Shanghai, China.

    Soluble fibrinogen-like protein 2 (sFGL2) is a novel immunoregulatory molecule, secreted mainly by regulatory T cells. CD11b+ Gr1+ myeloid-derived suppressor cells (MDSCs) are an important…
  • 2018 American Transplant Congress

    Influence of X-Ray Repair Cross-Complementing Group (XRCC) Genes Polymorphisms on the Development of Antibody-Mediated Rejection (ABMR) in Renal Transplant Recipients

    Z. Wang, Z. Han, J. Tao, R. Tan, M. Gu.

    Department of Urology, The First Affiliated Hospital with Nanjing Medical University, Nanjing, China.

    The importance of antibody-mediated rejection (ABMR) on the renal transplant recipients has been recognized in recent years. However, the pathogenesis of ABMR following kidney transplantation…
  • 2018 American Transplant Congress

    Eluates from Fine-Needle Allograft Biopsy Increase Donor-Specific Antibody Identification in Antibody Mediated Rejection

    A. Girnita,1,2 E. Portwood,2 P. Brailey,2 M. Cuffy,1 M. Cardi,1 F. Paterno,1 T. Diwan,1 S. Shah,1 A. Govil,1 R. Alloway,1 E. Woodle.1

    1University of Cincinnati, Cincinnati; 2Hoxworth Blood Center, Cincinnati.

    Aim. Antibody mediated rejection (AMR) represents a risk for graft loss, and the presence of circulating donor-specific antibody (cDSA) is a major criterion for AMR…
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