ATC Abstracts

American Transplant Congress abstracts

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  • 2018 American Transplant Congress

    Confirmation of the Feasibility of Ex Vivo Creation of a Novel Human Multi-Chimeric Cells Therapy for Tolerance Induction in Vascularized Composite Allotransplantation

    J. Cwykiel, G. Rafidi, M. Siemionow.

    Orthopaedics, University of Illinois at Chicago, Chicago, IL.

    Purpose:Various stem cell-based therapies have been proposed as supportive treatments for patients following solid organ and vascularized composite allotransplantation (VCA) to achieve donor-specific tolerance and…
  • 2018 American Transplant Congress

    Expression of the Senescence Marker P16/INK4A in Kidney Implantation Biopsies is Uniquely Associated with Poor Late Graft Function

    K. Famulski, P. Halloran.

    University of Alberta, Edmonton, Canada.

    With the aging donor population, accurate assessment of tissue quality of deceased donor kidneys is required to determine the intermediate and long term graft performance,…
  • 2018 American Transplant Congress

    The Impact of Aorto-Iliac Calcifications on Patient and Graft Survival in Renal Transplant Recipients Using the TASC II Classification

    A. Rijkse,1 M. van der Zijden,2 J. Roodnat,2 S. Ten Raa,3 D. Bijdevaate,4 K. Muller,1 J. IJzermans,1 H. Kimenai,1 R. Minnee.1

    1Department of Transplantation Surgery, Erasmus University Medical Center, Rotterdam, Netherlands; 2Department of Internal Medicine, Erasmus University Medical Center, Rotterdam, Netherlands; 3Department of Vascular Surgery, Erasmus University Medical Center, Rotterdam, Netherlands; 4Department of Radiology, Erasmus University Medical Center, Rotterdam, Netherlands.

    Introduction: Kidney transplantation (KTx) is the therapy of choice in patients with end-stage renal disease. Aorto-iliac calcifications (AIC) are a relative contra-indication for KTx, even…
  • 2018 American Transplant Congress

    LDLT for High MELD Recipients: A Single Center Experience

    S. Ganesh, M. Molinari, T. Amit, H. Christopher, H. Abhinav.

    Surgery, University of Pittsburgh, Pittsburgh, PA.

    Objectives: Living donor liver transplantation (LDLT) is underutilized in high MELD patients. Our aim was to assess the impact of high MELD score on short-term…
  • 2018 American Transplant Congress

    HCV Ab+/NAT- Organ Donors, and the Challenges of 'Eclipse Windows': Analysis of the OPTN/UNOS Ad Hoc Disease Transmission Advisory Committee (DTAC)

    C. Wolfe, S. Tlusty, G. Vece, R. Sawyer, R. Bag, G. Berry, J. Bucio, L. Danziger-Isakov, D. Goldberg, C. Ho, D. Florescu, D. Klassen, R. La Hoz, K. Lilly, A. Mehta, M. Malinis, M. Nalesnik, N. Theodoropoulos, P. Wood, M. Michaels.

    DTAC, United Network for Organ Sharing, Richmond, VA.

    Introduction: In 2017, CDC reported new hepatitis C (HCV) cases had tripled over 5 years, mainly due to intravenous drug use (IVDU). As the proportion…
  • 2018 American Transplant Congress

    Relationship between Mixed Chimerism and Acceptance of HLA-Matched and Mismatched Kidney Transplants after Withdrawal of Immunosuppressive Drugs

    J. Scandling, S. Busque, R. Lowsky, J. Shizuru, K. Jensen, A. Shori, E. Engleman, E. Meyer, R. Hoppe, S. Strober.

    Stanford University, Stanford, CA.

    Classical studies in cattle and rodents showed that mixed chimerism (MXC) established in fetuses and neonates was permanent, linked to immune tolerance and graft acceptance…
  • 2018 American Transplant Congress

    T cell Phenotypes Predict Infectious Risk in Transplanted Children

    E. T. Chambers,1 R. Ettenger,2 H.-J. Lee,1 C. Chan,1 L. Stempora,1 B. Warshaw,3 P. Grimm,4 E. F. Reed,2 M. Sarwal,5 A. Kirk.1

    1Pediatrics/Surgery, Duke University, Durham; 2Pediatrics, UCLA, Los Angeles; 3Pediatrics, Emory, Atlanta; 4Pediatrics, Stanford, Palo Alto; 5Surgery, UCSF, San Francisco.

    AIM: Current monitoring strategies do not adequately differentiate infection from complications such as allograft rejection (AR). We aimed to identify peripheral T cell phenotypes that…
  • 2018 American Transplant Congress

    Bioinformatics Approach to the Development of a Novel Molecular Biomarker for Sub-Clinical Acute Rejection (subAR) in the Peripheral Blood Following Kidney Transplant (KT)

    T. Whisenant,1 S. Kurian,1 M. Kandpal,2 L. Zhao,2 D. Ikle,3 B. Armstrong,3 J. Friedewald,2 R. Heilman,4 E. Poggio,5 C. Marsh,1 P. Baliga,6 N. Bridges,7 J. Odim,7 M. Brown,7 J. Charette,2 S. Brietigam,2 N. Sustento-Reodica,2 D. Salomon,1 M. Abecassis.2

    1Scripps, La Jolla; 2Northwestern, Chicago; 3Rho, Chapel Hill; 4Mayo AZ, Scottsdale; 5Cleveland Clinic, Cleveland; 6MUSC, Charleston; 7NIAID, Bethesda.

    Sub-clinical acute rejection (subAR) following KT is associated with poor long-term graft outcomes and can only be detected using invasive surveillance biopsies (SBx). Non-invasive biomarker…
  • 2018 American Transplant Congress

    Impact of ELAD C3A Cell Conditioned Medium Enhanced Perfusate Fluid on Functional Recovery of Extended Criteria Donor Livers during Normothermic Machine Perfusion

    S. Afford,2 L. Wallace,2 R. Laing,2 Y. Botteon,2 D. He,3 S. Soundararajan,4 D. Mirza,1 R. Ashley,3 J. Brotherton,3 H. Mergental,1 D. Reich.4

    1Queen Elizabeth Hospital, Birmingham, United Kingdom; 2University of Birmingham, Birmingham, United Kingdom; 3Vital Therapies Inc, San Diego, CA; 4Drexel University, Philadelphia.

    Reconditioning of donor livers by Normothermic Machine Perfusion (NMP) is already increasing the numbers of transplantable organs from the extended criteria donors. The hepatoblastoma-derived cell…
  • 2018 American Transplant Congress

    The Impact of Childhood Solid Organ Transplantation on B-Cell Maturation

    L. Ionescu,1 T. Blydt-Hansen,2 B. Foster,7 S. Mital,3 L. Hamiwka,5 U. Allan,3 V. Phan,4 P. Birk,6 C. Morgan,1 S. Urschel.1

    1U of Alberta, Edmonton, Canada; 2U of BC, Vancouver, Canada; 3Hospital for Sick Children, Toronto, Canada; 4U de Montreal, Montreal, Canada; 5U of Calgary, Calgary, Canada; 6U of Manitoba, Winnipeg, Canada; 7McGill University, Montreal, Canada.

    Background:The developing immune system of childhood promotes better graft acceptance and longevity but also higher risk for infections and post-transplant (Tx) lymphoproliferative disorders. This may…
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