ATC Abstracts

American Transplant Congress abstracts

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  • 2018 American Transplant Congress

    Temporal and Geographical Trends of Intestinal Transplantation in the USA

    M. Segovia,1 S. Jafri,3 B. Summers,3 T. Schiano,2 T. Pietrowsky,3 A. Al-Osaimi,5 A. Mavis,1 S. Horslen.4

    1Duke Univ, Durham; 2Mt Sinai Hosp, NY; 3Henry Ford Hosp, Detroit; 4Seattle Children's Hosp, Seattle; 5Temple Univ, Philadelphia.

    Intestinal transplantation (IT) is uncommon compared to other organ transplants. We examined the temporal and geographical trends of centers that perform IT in the USAWe…
  • 2018 American Transplant Congress

    Graft Dendritic Cell p40 Homodimers Activate Donor-Reactive Endogenous Memory CD8 T Cells within Higher Risk Allografts

    H. Tsuda, A. Valujskikh, R. Fairchild.

    Immunology, Cleveland Clinic, Cleveland, OH.

    Memory T cells with donor-reactivity pose a major barrier to successful allograft transplantation and tolerance induction. Longer cold ischemic storage (CIS) prior to transplantation promotes…
  • 2018 American Transplant Congress

    Determining the Relative Immunogenicity of HLA Mismatches with Calcineurin Inhibitor Immunosuppression: An Analysis of the BENEFIT and BENEFIT-EXT Renal Transplant Cohort

    V. Jucaud,1 M. Roberts,2 H. Gebel,3 R. Bray,3 M. Everly.1

    1Terasaki Research Institute, Los Angeles, CA; 2Immunology Biomarker Group, Bristol-Myers Squibb, Princeton, NJ; 3Pathology & Laboratory Medicine, Emory University School of Medicine, Atlanta, GA.

    We studied the relative immunogenicity of HLA-A, -B, -C, -DR and -DQ MM (serological) in a cohort of 291 kidney transplant patients from the BENEFIT…
  • 2018 American Transplant Congress

    Urinary Tract Infections after Renal Transplantation: Is Male Gender a Risk Factor for Resistant Microorganisms?

    G. Guneri, A. Velioglu, E. Asicioglu, H. Arikan, S. Tuglular, C. Ozener.

    Nephrology, Marmara University, School of Medicine, Istanbul, Turkey.

    Introduction: Renal transplantation is the most effective treatment method for patients with the end-stage renal disease. The most common infections among these patients are urinary…
  • 2018 American Transplant Congress

    Ischemia Reperfusion Injury in Liver Transplantation is Associated with Acute Kidney Injury: Role of Inflammatory Mediators

    P. Mihaylov,1,2 P. Li,1 J. Skill,1 L. Timsina,1 J. Fridell,1 B. Ekser,1 R. Mangus,1 C. Kubal.1

    1Surgery, Indiana University, Indianapolis; 2Surgery, University of Pavia, Pavia, Italy.

    Background: The impact of liver allograft ischemia/reperfusion injury (IRI) on native renal function remains to be characterized. We hypothesized that elevated levels of circulating inflammatory…
  • 2018 American Transplant Congress

    Screening of RhoA/ROCK Inhibitors for the Ability to Prevent Chronic Rejection of Mouse Cardiac Allografts

    W. Chen, W. Chen, X. Li, R. Ghobrial, M. Kloc.

    THMRI, Houston, TX.

    Objectives. Chronic rejection of transplanted organs is a major obstacle in human organ transplantation. Although the mechanisms of chronic rejection are poorly understood it is…
  • 2018 American Transplant Congress

    Ex Vivo Expanded Regulatory B Cells Promote Allograft Survival through IL-10-Dependent Pathway

    K. Lee, K. Deng, L. Kojima, C. Dai, C. Rickert, H. Yeh, J. Markmann.

    Massachusetts General Hospital, Boston.

    Immunomodulatory capacity of B cells make them a promising therapeutic tool for autoimmune and alloimmune response in patients. We found that transplant tolerance induced by…
  • 2018 American Transplant Congress

    Recombinant Relaxin Protects Liver Transplants from Ischemia-Reperfusion Damage via Hepatocyte Glucocorticoid Receptor: From Bench-to-Bedside

    S. Kageyama,1 K. Nakamura,1 T. Ito,1 A. Aziz,1 B. Ke,1 R. Sossa,2 E. Reed,2 F. Kaldas,1 R. Busuttil,1 J. Kupiec-Weglinski.1

    1Surgery, Division of Liver Transplantation, UCLA, Los Angeles, CA; 2Pathology, UCLA, Los Angeles, CA.

    Hepatic ischemia-reperfusion injury (IRI) represents a major risk factor of early graft dysfunction and acute/chronic rejection as well as a key obstacle to expanding the…
  • 2018 American Transplant Congress

    Decreased Long-Term Survival with Antithymocyte Globulin Induction in Elderly Kidney Transplant Recipients

    I. Bajjoka, A. Yaldo, C. Crombez, M. Abouljoud.

    Henry Ford Transplant Institute, Detroit, MI.

    Purpose: Long-term consequences of immunosuppression on the elderly is still unclear. This data to evaluates long-term outcomes for younger (Y) versus elderly (E) kidney transplant…
  • 2018 American Transplant Congress

    Non-Medical Factors Predict Receipt and Type of Kidney Transplant in Veterans

    K. Kendall, X. Li, C.-C. Chang, J. Pleis, E. Croswell, M. Dew, G. Switzer, A. Langone, A. Mittal-Henkle, S. Saha, M. Ramkumar, J. Adams-Flohr, C. Thomas, L. Myaskovsky.

    VA Kidney Transplant Centers: IA, OR, PA, TN, Iowa City, Portland, Pittsburgh, Nashville.

    Background: African Americans, Hispanic Americans and other minorities have a higher incidence of end-stage kidney disease but lower rates of both deceased and living donor…
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