2018 American Transplant Congress
Temporal Changes in the Characteristics and Sensitization of Kidney Paired Donation Registrants
In order to utilize a willing but incompatible living donor, candidates must either proceed with incompatible transplantation or find a more compatible match using kidney…2018 American Transplant Congress
Diagnostic Value and Confounding Factors of Urinary Biomarkers in the Non-Invasive Screening of Renal Allograft Inflammation
IntroductionThe value of urinary biomarkers has already been demonstrated in diagnosing acute rejection of the renal allograft, but confounding factors, which may interfere with their…2018 American Transplant Congress
Evaluating Center Performance beyond Patient and Graft Survival
Baylor University Medical Center, Dallas, TX.
Introduction: LT centers are judged by patient survival at 1-yr post LT; however risk incurred on the waitlist or center specific practices post LT are…2018 American Transplant Congress
Discovery and Validation of a Urinary Exosome mRNA Signature for the Diagnosis of Human Kidney Transplant Rejection
1Transplantation Renal Center, BWH and BCH, Boston; 2Exosome Diagnostic Inc., Cambridge.
Kidney transplant rejection leads to short and long-term adverse clinical outcomes. Serum creatinine is a suboptimal late biomarker for rejection. Exosomes are nanometer-sized vesicles released…2018 American Transplant Congress
Role of C1q-Binding Donor-Specific Anti-HLA Antibodies in Premature and Accelerated Kidney Allograft Interstitial Fibrosis
Paris Translational Research Center for Organ Transplantation, Paris, France.
The 2017 Banff meeting has focused on the importance of a precise diagnosis of IF/TA in kidney recipients by addressing specific etiological factors. Recent studies…2018 American Transplant Congress
RNA Expression Profiling of Renal Allografts in the Cynomolgus Monkey Identifies Tolerance
IntroductionTolerance induction is a long standing clinical goal. However, identification remains elusive. Here we profile intra-renal allograft RNA expression in a mixed chimerism renal allograft…2018 American Transplant Congress
Rituximab Interference in B-Cell Crossmatch: A Problem Solved
Background: Rituximab is commonly prescribed in ABO- or HLA-incompatible kidney transplantation. When used before transplant it interferes with B lymphocyte complement-dependent crossmatch (CDC CM) or…2018 American Transplant Congress
A 3C Approach Drives Epigenetic Fixation of Foxp3 Expression and Stabilizes Treg Cell Lineage and Therapeutic Function
Immunobiology & Transplant Research Center, Houston Methodist Hospital, Houston, TX.
The instability of the regulatory T (Treg) cell lineage precludes their therapeutic potential in transplantation and autoimmune diseases. Herein, we invented a novel approach to…2018 American Transplant Congress
Cost Impacts of Alternative Kidney Transplant Immunosuppression: A National Cohort Study
Economic outcomes are increasingly considered along with clinical efficacy to guide choice of alternative therapies. We examined the cost impact of kidney transplant (KTx) induction…2018 American Transplant Congress
Long Term Histologic Allograft Health is Preserved Despite Rejection during Protocolized Immunosuppression Withdrawal (ISW) in Stable Pediatric Liver Transplant Recipients
Background: Long term allograft health after rejection during ISW has not been previously assessed. We compare baseline and 4yr graft histology of 20 rejectors in…
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