ATC Abstracts

American Transplant Congress abstracts

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  • 2018 American Transplant Congress

    Anti-Thymocyte Globulin Directly Binds and Functionally Inhibits Allo-Regulatory Myeloid Derived Suppressor Cells

    Y. Lee, E. Davila, J. Bromberg, J. Scalea.

    Surgery and Immunology, University of Maryland, Baltimore, MD.

    BACKGROUND: Myeloid-derived suppressor cells (MDSCs) are a heterogeneous group of naturally occurring, immunosuppressive cells that may be exploitable in transplantation.There are only a few incomplete…
  • 2018 American Transplant Congress

    p40 Homodimer Induced Proliferation of Endogenous Donor-Reactive Memory CD8 T Cells within High Risk Allografts Requires Memory CD8 T Cell Expression of CD122

    H. Tsuda, A. Valujskikh, R. Fairchild.

    Immunology, Cleveland Clinic, Cleveland, OH.

    Increasing the duration of cold ischemic storage (CIS) from 0.5 to 8 hrs prior to transplant induces the increased proliferation of endogenous donor-reactive CD4 and…
  • 2018 American Transplant Congress

    A Novel Endothelial Cell Based Complement Dependent Cytotoxicity Test in Kidney Transplantation

    R. Lammerts,1 J. van den Born,1 W. Dam,1 M. Seelen,1 B. Hepkema,2 B. Kroesen,2 M. Daha,1 R. Pol,3 S. Berger,1 On behalf of the COMBAT Consortium.1

    1Department of Nephrology, University Medical Centre Groningen, Groningen, Netherlands; 2Department of Immunology, University Medical Centre Groningen, Groningen, Netherlands; 3Department of Surgery, University Medical Centre Groningen, Groningen, Netherlands.

    Introduction:Relevant alloantibodies in kidney transplantation comprise anti-HLA antibodies, blood group antibodies (ABO incompatible) and anti-endothelial cell antibodies (AECA) and can initiate antibody-mediated rejection (ABMR). ABMR…
  • 2018 American Transplant Congress

    Single vs. Multi-Drug Antibiotic Prophylaxis for Continuous-Flow Left Ventricular Assist Device Implantation: A Systematic Review and Meta-Analysis

    S. Patel,1 J. Choi,1 E. Moncho Escrivà,2 S. Rizvi,1 L. Samuels,1 J. Luc,3 R. Morris,1 H. Massey,1 V. Tchantchaleishvili,1 N. Aburjania.4

    1Division of Cardiac Surgery, Thomas Jefferson University, Philadelphia, PA; 2University of Granada, Granada, Spain; 3University of Alberta, Edmonton, AB, Canada; 4Division of Infectious Diseases, Thomas Jefferson University, Philadelphia, PA.

    Purpose: Despite the fact that infection remains a major complication of continuous-flow left ventricular assist device (CF-LVAD) therapy, an optimal antimicrobial surgical infection prophylaxis (SIP)…
  • 2018 American Transplant Congress

    Cardiac MRI May Help to Determine When to Refer Heart Transplant Patients for Redo Heart Transplant

    M. Kittleson, J. Patel, E. Kransdorf, S. Dimbil, R. Levine, D. Geft, D. Chang, L. Czer, J. Kobashigawa.

    Cedars Sinai Medical Center, Los Angeles.

    Purpose: Small vessel coronary artery disease is known to cause fibrosis. However, it is not clear whether myocardial fibrosis detected on MRI is associated with…
  • 2018 American Transplant Congress

    Early Adjunctive Treatment with Human Cytomegaly Virus (CMV) Immunoglobulin Increased CMV-Free Survival after Heart Transplantation

    M. Barten,1 C. Neumaier,1 A. Bernhardt,1 M. Rybczynski,2 R. Plaetke,3 H. Reichenspurner.1

    1Cardiovascular Surgery, University Heart Center Hamburg, Hamburg, Germany; 2General and Interventional Cardiology, University Heart Center Hamburg, Hamburg, Germany; 3Institute of Medical Biometry and Epidemiology, University Hospital Eppendorf Hamburg, Hamburg, Germany.

    Purpose: There is still an ongoing discussion whether a prophylactic or a preemptive therapy against cytomegalovirus (CMV) is superior to reduce the incidence of CMV…
  • 2018 American Transplant Congress

    “I'll Be Back”: Increasing Readmission Rates in the Era of the New Kidney Allocation System

    N. Pilch, C. Mardis, H. Meadows, J. Fleming, N. Patel, C. Perez, P. Baliga, D. Dubay, V. Rohan, V. Rao, D. Taber.

    MUSC, Charleston.

    Background: National analysis of the impact of the new KAS has indicated an increase in DGF rates, total inpatient hospital costs & 30 day readmission…
  • 2018 American Transplant Congress

    Sharing Works; Avoiding Kidney Transplantation to an Unintended Recipient by Precision Virtual Cross Match with Excellent Outcomes

    G. Roll,1 A. Webber,1 M. Travakol,1 D. Gae,1 L. Mayen,2 V. Corpuz,1 J. Roberts,1 N. Ascher,1 P. Stock,1 R. Rajalingam.1

    1UCSF, San Francisco; 2Donor Network West, San Ramon.

    Aim: It was recently estimated that 19.2% of imported kidneys go into an unintended recipient(UR), most commonly due to a positive crossmatch(AJT 2017, 17:2139) so…
  • 2018 American Transplant Congress

    Reliability of Deceased Donor Procurement Biopsy Images at the Time of Kidney Allocation

    S. Mansour,1 E. Hall,2 P. Reese,3 Y. Jia,1 H. Thiessen-Philbrook,1 G. Moeckel,1 F. Weng,4 P. Revelo,2 M. Khalighi,2 A. Trivedi,5 M. Doshi,6 B. Schroppel,7 C. Parikh.1

    1Yale University School of Medicine, New Haven; 2University of Utah School of Medicine, Salt Lake City; 3Perelman School of Medicine at the University of Pennsylvania, Philadelphia; 4Saint Barnabas Medical Center, Livingston; 5Hartford Hospital, Hartford; 6Wayne State University, Detroit; 7University Hospital, Ulm, Germany.

    Histological findings of procurement deceased-donor kidney biopsies contribute to organ allocation decisions. Representative images of pathology on biopsy slides are often uploaded into United Network…
  • 2018 American Transplant Congress

    Higher Rates of Rejection in HIV-Infected Kidney Transplant Recipients on Ritonavir-Boosted Protease Inhibitors–Three-Year Follow Up

    B. Rollins, S. Farouk, G. DeBoccardo, S. Lerner, M. Rana, S. Huprikar, L. Miko, V. Delaney, S. Florman, R. Shapiro.

    The Mount Sinai Hospital, New York.

    Background: One-year rejection rates in HIV-infected kidney transplant recipients range from 15-40%, compared to overall rejection rates of 10% in HIV-negative patients. Protocols for immunosuppression…
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