2018 American Transplant Congress
Probability of Developing Chronic Kidney Disease 1 Year after Living Donor Nephrectomy Correlates with Baseline Kidney Volume and Function
University of Utah, Salt Lake City, UT.
Purpose: Living kidney donor outcomes are tremendously important, especially given expanding donor eligibility. Relative to other predictors, the relationship between remaining kidney volume and post-donation…2018 American Transplant Congress
Isolated Pre-Transplant Angiotensin II Type I Receptor Antibodies (AT1R Ab) Are Not Associated with Reduced Graft Function or Hypertension (HTN) in Pediatric Kidney Transplant (Ped KTx) Patients (pts)
Comprehensive Transplant Center, Cedars-Sinai Medical Center, Los Angeles, CA.
Background: Pre-tx donor-specific antibodies (DSA) raises the risk for antibody-mediated rejection (ABMR) and graft dysfunction. The role of AT1R Ab is unclear. In adults, post-tx…2018 American Transplant Congress
Analyzing Geographic Disparity in the US Heart Allocation System
Introduction: In the United States, the system to allocate solid organs for transplantation is regulated and maintained by the United Network for Organ Sharing (UNOS).…2018 American Transplant Congress
Survey of Rabbit Anti-Thymocyte Globulin Usage for Kidney Transplant Induction Therapy in the United States
Background: Rabbit anti-thymocyte globulin (rATG) has become the most widely used induction agent in kidney transplantation (KTx) and has recently received FDA approval for this…2018 American Transplant Congress
Autologous Adipose-Derived Stem Cells with In Vivo Immunomodulatory Properties Can Be Generated in Allograft Recipients under Immunosuppression
PurposeTo determine if it is possible to generate mesenchymal stem cells (MSC) with potent in vivo immunomodulatory properties in allograft recipients under immunosuppression, we analyzed…2018 American Transplant Congress
A Retrospective Review of De Novo Coccidioidomycosis among Remote Solid Organ Transplant Recipients in Arizona
Background: Solid organ transplant (SOT) recipients residing in a Coccidioides-endemic region that acquire infection are at risk for complicated and protracted infection. Following transplantation, prophylaxis…2018 American Transplant Congress
Characterization of Viral and Host Cell Genomic Alterations in EBV+ PTLD
1Abdominal Transplant, Stanford University, Stanford; 2Pathology, Stanford University, Stanford.
Post-transplant lymphoproliferative disorder (PTLD) is a potentially fatal complication of organ transplantation characterized by abnormal proliferation of lymphoid cells in the setting of immunosuppression after…2018 American Transplant Congress
Risk Factors and Outcomes with Extended-Spectrum Beta-Lactamase-Producing Enterobacteriaceae Bloodstream Infections among Solid Organ Transplant Recipients
Objective: Solid organ transplant recipients (SOTR) have been significantly impacted by the emergence of multidrug-resistant bacteria, including extended-spectrum beta-lactamase (ESBL)-producing Enterobacteriaceae (EB). We determined the…2018 American Transplant Congress
MERTK Mediates Transplant Tolerance via IFN-a Regulation of MDSCs and Tregs
Northwestern University Feinberg School of Medicine, Chicago.
Introduction: MERTK is one of the TAM receptor tyrosine kinases (RTKs) that mediate homeostatic phagocytosis of apoptotic cells, and transmit regulatory signals that modulate immune…2018 American Transplant Congress
Pilot Study of Plasma Cell Niche-Targeted Therapy for Enhancement of Proteasome Inhibitor Effectiveness
1UCincinnati, Cincinnati; 2Cincinnati Children's, Cincinnati; 3Duke, Durham.
HLA antibody (Ab)-secreting bone marrow (BM) plasma cell (PC) survival depends on niche occupancy via a CXCR4 (PC)-CXCL12 (BM stromal cell) interaction. Plerixafor inhibits CXCR4-CXCL12…
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