Am J Transplant, Volume 18, Suppl 3 Archives - Page 23 of 211 - ATC Abstracts

2018 American Transplant Congress
Not All HLA Mismatches Are Equal: Determining the Relative De Novo DSA Induction Capacity of HLA Mismatches
V. Jucaud,¹ L. Rebellato,² K. Briley,² A. Maldonado,³ C. Haisch,² P. Bolin,² S. Kendrick,⁴ H. Jones,⁴ K. McLawhorn,⁴ D. Leeser,² M. Everly.¹
¹Terasaki Research Institute, Los Angeles, CA; ²East Carolina University, Greenville, NC; ³Vidant Medical Center, Greenville, NC; ⁴Eastern Nephrology Associates, Greenville, NC.
We studied the immunogenicity, defined as the development of de novo DSA (dnDSA), of HLA-A, -B, -DR and -DQ MM (serological) in a cohort of…
2018 American Transplant Congress
Center Variation in Six-Month Post-Donation Follow-Up of Obese Living Kidney Donors
R. Reed,¹ P. MacLennan,¹ B. Shelton,¹ M. Mustian,¹ D. McWilliams,¹ J. Blackburn,² D. Sawinski,³ J. Locke.¹
¹Surgery, University of Alabama at Birmingham, Birmingham, AL; ²Health Care Organization & Policy, University of Alabama at Birmingham, Birmingham, AL; ³Medicine, University of Pennsylvania, Philadelphia, PA.
Introduction: While post-donation follow-up in the United States has improved since implementation of minimum center compliance standards, it is still suboptimal and brief (only 2…
2018 American Transplant Congress
Long-Term Risk of Solid Organ De Novo Malignancies after Liver Transplantation: A French National Study on 11226 Patients
O. Seree, M. Altieri, J. Dumortier, GReF2.
Réseau Régional de Cancérologie Onco-Basse Normandie, Herouville St-Clair, France; Service d'Hépato-Gastroentérologie, Nutrition et Oncologie Digestive, CHU CAEN Hôpital Côte de Nacre, Caen, France; Hospices Civils de Lyon, Lyon, France.
Background and aims: De novo malignancies are one of the major late complications and cause of death after liver transplantation (LT). Using extensive data from…
2018 American Transplant Congress
In-Vivo Visualization of Regulatory B Cells Reveals Ag-Dependent T Cell Interactions That Suppress Subsequent T Cell:DC Interactions
K. Mohib, A. Cherukuri, Y. Zhou, R. David.
Starzl Transplantation Institute, Univ. of Pittsburgh, Pittsburgh, PA.
We showed that regulatory B cells (Bregs) promote long-term islet allograft survival. Using mice with a novel inducible B cell-specific deletion of IL-10 (IL-10fl/flXhCD20TAM-Cre) we…
2018 American Transplant Congress
Hospital Readmissions Following ABO-Incompatible Live Donor Kidney Transplantation: A National Study
B. Orandi,¹ X. Luo,² S. Bae,² E. King,² J. Garonzik-Wang,² D. Segev.²
¹UCSF, San Francisco; ²Hopkins, Baltimore.
30% of kidney transplant recipients are readmitted in the first month post-transplant. ABO-incompatible (ABO-I) recipients constitute a unique subpopulation that might be at higher readmission…
2018 American Transplant Congress
An Early Look at the OPTN's New SLK Allocation Policy
A. Kucheryavaya,¹ R. Formica,² N. Turgeon,³ D. Stewart,¹ A. Wilk.¹
¹UNOS, Richmond; ²Yale School of Medicine, New Haven; ³Emory Univ Hosp, Atlanta.
Background: The new Simultaneous Liver-Kidney (SLK) allocation policy went into effect on 8/10/17. It established renal medical criteria for patients waiting for SLK transplants and…
2018 American Transplant Congress
Urine AngiotensinII Signature Proteins as Biomarkers of Fibrosis in Kidney Transplant Recipients
Z. Mohammed-Ali,¹ S. Reid,^1,3 T. Tokar,¹ A. Tavares,² P. Yip,¹ H. Cardinal,² Y. Li,¹ S. Kim,^1,3 I. Jurisica,^1,3 R. John,¹ A. Konvalinka.^1,3
¹University Health Network, Toronto, ON, Canada; ²Centre de Recherche du Centre Hospitalier de l'Université de Montréal, Montréal, QC, Canada; ³University of Toronto, Toronto, ON, Canada.
AngiotensinII (AngII), the main effector of the renin-angiotensin system (RAS), causes kidney interstitial fibrosis/tubular atrophy (IFTA). However, there are presently no markers of AngII renal…
2018 American Transplant Congress
Immune Phenotyping in a Pediatric Multicenter Transplant Study: Suitability of a Pre-Formulated Dry Antibody Panel System
S. Urschel,¹ L. Ionescu,¹ T. Blydt-Hansen,³ B. Foster,⁵ S. Mital,² U. Allan,² S. Iveson,³ L. Hamiwka,⁴ J. Yap,¹ V. Phan,⁵ P. Birk,⁶ L. West,¹ M. Levings.³
¹U of Alberta, Edmonton, Canada; ²Sickkids, Toronto, Canada; ³U of BC, Vancouver, Canada; ⁴U of Calgary, Calgary, Canada; ⁵Montreal Children's, Montreal, Canada; ⁶U Manitoba, Winnipeg, Canada.
Background:Flow cytometric immune-phenotyping is influenced by cryopreservation and inter-laboratory variability limiting comparability in multi center studies. The Duraclone™ system (DC) provides optimized pre-mixed dry antibody…
2018 American Transplant Congress
Ischemia Reperfusion Injury Significantly Differs between Lung vs. Heart Transplantation with Respect to Lead Cytokines and Correlation to Clinical Outcome
B. Wiegmann,¹ N. Ledwoch,² J. ISke,² C. Neudörfl,² I. Tudorache,¹ C. Kühn,¹ T. Kaufeld,¹ F. Ius,¹ S. Rojas,¹ M. Avsar,¹ A. Haverich,¹ G. Warnwcke,¹ C. Falk.¹
¹Department of Cardiothoracic Transplantation and Vascular Surgery, Hannover Medical School, Hannover, Germany; ²Institute of Transplant Immunology, Hannover Medical School, Hannover, Germany.
ObjectivesIschemia reperfusion injury (IRI) is known to impair early graft function after lung (LTx) or heart (HTx) transplantation. We have previously characterized IRI in lungs…
2018 American Transplant Congress
Absolute Quantification of Plasma Graft-Derived Cell-Free DNA for Diagnosis of Kidney Transplant Rejection
J. Whitlam,¹ L. Ling,² F. Ierino,³ D. Bruno,² H. Slater,² D. Power.¹
¹Austin Health, Heidelberg, Victoria, Australia; ²Murdoch Childrens Research Institute, Parkville, Victoria, Australia; ³St Vincent's Health, Fitzroy, Victoria, Australia.
Aim: To study the performance of droplet digital PCR absolute measurement of graft-derived cell-free DNA (gdcfDNA) for the diagnosis of kidney allograft rejection.Methods: Homozygous deletion…