Am J Transplant, Volume 18, Suppl 3 Archives - Page 22 of 211 - ATC Abstracts

2018 American Transplant Congress
Dual Inhibition of PI3K and mTORC2 Causes ERK Hyperactivation Induced by HLA-II Antibody in Human Endothelium
Y-.P. Jin, E. Reed.
Pathology and Laboratory Medicine, David Geffen School of Medicine, UCLA, Los Angeles, CA.
Background: Endothelial cells (EC) line the inner surface of blood vessels and serve as the interface between recipient circulating blood and the donor allograft. Transplant…
2018 American Transplant Congress
A Follow-Up Report on the Use of IVIG+Rituximab to Reduce Donor Specific Antibodies and Improve Transplant Rates in Highly-Sensitized Patients Awaiting Deceased Donor Kidney Transplantation
R. Najjar, E. Huang, A. Vo, J. Choi, K. Lim, S. Louie, A. Peng, S. Sethi, M. Toyoda, X. Zhang, S. Jordan.
Medicine/Nephrology, Cedars Sinai Medical Center, Los Angeles, CA.
Introduction: Desensitization (DES) with IVIG/rituximab is associated with a reduction in donor specific antibodies (DSA), improved transplant rates and outcomes in highly-sensitized (HS) patients. We…
2018 American Transplant Congress
Kidney Transplantation and Progression of Peripheral Arterial Disease in the Ipsilateral Lower Extremity
A. Rasmussen,¹ R. Moore,¹ T. Schuler,¹ G. Todd,¹ K. Wen.²
¹Division of Urology, Department of Surgery, University of Alberta, Edmonton, AB, Canada; ²Division of Nephrology and Transplant Immunology, Department of Medicine, University of Alberta, Edmonton, AB, Canada.
Objectives:We aimed to investigate whether receiving a kidney transplant allograft graft increases the risk of ipsilateral lower limb amputation in patients with pre-existing peripheral arterial…
2018 American Transplant Congress
Estimation of Mortality on the Wait List
S. Asrani, L. Jennings, J. Trotter, G. Klintmalm.
Baylor University Medical Center, Dallas, TX.
Background: Since the introduction of MELD and MELDNa, the waitlist population has changed. Further, serum creatinine is a poor surrogate of renal dysfunction in patients…
2018 American Transplant Congress
Consequences of Being Listed at a Small Pancreas Program
S. Niederhaus,¹ M. Curry,² A. Fox,² J. Fridell,³ J. Odorico.⁴
¹Surgery, University of Maryland, Baltimore, MD; ²UNOS, Richmond, VA; ³Surgery, Indiana University, Indianapolis, IN; ⁴Surgery, University of Wisconsin, Madison, WI.
How pancreas transplant center (PTC) volume affects patient outcomes after listing is unclear. Low volumes may lengthen waiting times or limit access to transplantation. We…
2018 American Transplant Congress
Living Liver Donor Follow-Up: Fewer Than Half of Centers Meet Follow-Up Requirements in the US
A. Thomas, C. Holscher, A. Shaffer, J. Garonzik-Wang, A. Massie, D. Segev, M. Henderson.
JHU, Baltimore.
OPTN/UNOS began requiring 1-year living donor follow-up (LDF) for living liver donors (LLDs) in 2014. Compliance with a similar policy for living kidney donors was…
2018 American Transplant Congress
T Cell Exhaustion in Kidney Transplant Patients
M. Fribourg,¹ C. Fischman,² L. Anderson,² B. Burrell,³ P. Heeger,² P. Cravedi.²
¹Department of Neurology, Icahn School of Medicine, New York; ²Department of Medicine, Icahn School of Medicine, New York; ³Immune Tolerance Network, Bethesda.
Background: T cell exhaustion is a dysfunctional state that arises during chronic infection and cancer in response to persistence of high antigenic load. Whether chronic…
2018 American Transplant Congress
Donor Liver Apoptosis is Associated with Early Allograft Dysfunction and Short-Time Graft Survival after Liver Transplantation
Z. Guo, Z. Zhu, Y. Tang, S. Huang, Z. Zhang, X. He, G. Chen.
Organ Transplant Center, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China.
Aims The aim of the study was to determine whether donor liver apoptosis is predictive for early allograft dysfunction (EAD) and graft survival after liver…
2018 American Transplant Congress
Time in Therapeutic Range Predicts DSA Development and Acute Rejection in Kidney Recipients with High Tacrolimus Coefficient of Variation
S. Davis, J. Gralla, P. Klem, A. Wiseman, J. Cooper.
University of Colorado, Aurora, CO.
High tacrolimus trough coefficient of variation (TAC CV) has been associated with an increased risk of de novo donor-specific antibody (dnDSA) and acute rejection (AR).…
2018 American Transplant Congress
What Deceased Donors Do KPD Candidates Accept?
A. Toll,¹ R. Leishman,¹ V. Casingal,² M. Aeder,³ T. Sandholm,⁴ N. Turgeon.⁵
¹UNOS, Richmond, VA; ²Carolinas HealthCare Sys, Charlotte, NC; ³Univ Hosp Med Ctr, Cleveland, OH; ⁴Carnegie Mellon Univ, Pittsburgh, PA; ⁵Emory Univ, Atlanta, GA.
Background: Possible utilization of deceased donors (DDs) to initiate KPD chains has been of interest to the transplant community. OPTN KPD candidates are required to…