Am J Transplant, Volume 18, Suppl 3 Archives - Page 22 of 211 - ATC Abstracts

2018 American Transplant Congress
RNA-Seq Based Analysis of Renal Allograft Biopsies Reveals Key Mediators of Interstitial Fibrosis/Tubular Atrophy
C. McEvoy,^1,2,4 E. Brennan,^1,2 A. Dorman,^2,3 D. Sadlier,^1,2 A. Konvalinka,⁴ P. Conlon,^2,3 C. Godson.^1,2
¹Diabetes Complications Research Centre, Conway Institute, School of Medicine, University College Dublin, Dublin, Ireland; ²North Dublin Renal Biobank, Dublin, Ireland; ³Beaumont Hospital & RCSI, Dublin, Ireland; ⁴University Health Network, Toronto, Canada.
Interstitial Fibrosis/Tubular Atrophy(IFTA) is the final common pathway of most progressive renal diseases and is a potent predictors of renal outcome in both native and…
2018 American Transplant Congress
The MicroRNA Landscape of EBV+ and EBV- PTLD
Y. Balachandran,¹ H. Zimmermann,² C. Esquivel,¹ S. Krams,¹ R. Trappe,² O. Martinez.¹
¹Transplant Immunology Laboratory/Division of Abdominal Transplant, Stanford University, Stanford; ²Department of Haematology and Oncology, DIAKO Ev. Diakonie-Krankenhaus Bremen, Bremen, Germany.
Post-transplant lymphoproliferative disorder (PTLD) is a potentially fatal complication of organ transplantation characterized by abnormal proliferation of lymphoid cells in the setting of immunosuppression after…
2018 American Transplant Congress
Contribution of mTOR Signaling to the β-Catenin Pathway in Regulatory T Cells
F. Marti, L. Turcios, A. Mohamed, M. Mitov, D. Butterfield, R. Gedaly.
Surgery, University of Kentucky, Lexington, KY.
Background: A growing body of evidence recognizes the balance between graft-reactive effector T cells and graft-protective regulatory T cells (Tregs) as the ultimate determinant of…
2018 American Transplant Congress
Organ Transplantation Associated with High Incidence of Anal Cancer and Pre-Cancer Lesions among HIV-Infected Women and Men
P. Chin-Hong,¹ B. Barin,² M. Berry,¹ M. DaCosta,¹ T. Darragh,¹ L. Rosenthal,³ S. Bartlett,⁴ D. Dieterich,⁵ F. Poordad,⁶ N. Nissen,⁶ M. Wong,⁷ P. Stock,¹ J. Palefsky.¹
¹University of California, San Francisco, San Francisco; ²EMMES, Rockville; ³Columbia University, New York; ⁴University of Maryland, Baltimore; ⁵Icahn School of Medicine at Mount Sinai, New York; ⁶Cedars-Sinai Medical Center, Los Angeles; ⁷Beth Israel Deaconess Medical Center, Boston.
Objective: HIV-infected women and men and transplant recipients are two populations at increased risk of HPV-associated anal cancer but there is little published data. We…
2018 American Transplant Congress
Unsupervised Analysis of the Alloimmune Response in a Novel Model of Vascularized Composite Allotransplantation
J. Harden, A. Sang, X. Qu, C. Esquivel, O. Martinez, S. Krams.
Department of Surgery/Division of Abdominal Transplantation, Stanford University, Stanford, CA.
Vascularized composite allografts consists of skin, muscle, bone, and other tissues, and is more immunogenic than solid-organ allografts. Our laboratory developed a murine model to…
2018 American Transplant Congress
Dual Inhibition of PI3K and mTORC2 Causes ERK Hyperactivation Induced by HLA-II Antibody in Human Endothelium
Y-.P. Jin, E. Reed.
Pathology and Laboratory Medicine, David Geffen School of Medicine, UCLA, Los Angeles, CA.
Background: Endothelial cells (EC) line the inner surface of blood vessels and serve as the interface between recipient circulating blood and the donor allograft. Transplant…
2018 American Transplant Congress
A Follow-Up Report on the Use of IVIG+Rituximab to Reduce Donor Specific Antibodies and Improve Transplant Rates in Highly-Sensitized Patients Awaiting Deceased Donor Kidney Transplantation
R. Najjar, E. Huang, A. Vo, J. Choi, K. Lim, S. Louie, A. Peng, S. Sethi, M. Toyoda, X. Zhang, S. Jordan.
Medicine/Nephrology, Cedars Sinai Medical Center, Los Angeles, CA.
Introduction: Desensitization (DES) with IVIG/rituximab is associated with a reduction in donor specific antibodies (DSA), improved transplant rates and outcomes in highly-sensitized (HS) patients. We…
2018 American Transplant Congress
Kidney Transplantation and Progression of Peripheral Arterial Disease in the Ipsilateral Lower Extremity
A. Rasmussen,¹ R. Moore,¹ T. Schuler,¹ G. Todd,¹ K. Wen.²
¹Division of Urology, Department of Surgery, University of Alberta, Edmonton, AB, Canada; ²Division of Nephrology and Transplant Immunology, Department of Medicine, University of Alberta, Edmonton, AB, Canada.
Objectives:We aimed to investigate whether receiving a kidney transplant allograft graft increases the risk of ipsilateral lower limb amputation in patients with pre-existing peripheral arterial…
2018 American Transplant Congress
Estimation of Mortality on the Wait List
S. Asrani, L. Jennings, J. Trotter, G. Klintmalm.
Baylor University Medical Center, Dallas, TX.
Background: Since the introduction of MELD and MELDNa, the waitlist population has changed. Further, serum creatinine is a poor surrogate of renal dysfunction in patients…
2018 American Transplant Congress
Consequences of Being Listed at a Small Pancreas Program
S. Niederhaus,¹ M. Curry,² A. Fox,² J. Fridell,³ J. Odorico.⁴
¹Surgery, University of Maryland, Baltimore, MD; ²UNOS, Richmond, VA; ³Surgery, Indiana University, Indianapolis, IN; ⁴Surgery, University of Wisconsin, Madison, WI.
How pancreas transplant center (PTC) volume affects patient outcomes after listing is unclear. Low volumes may lengthen waiting times or limit access to transplantation. We…