ATC Abstracts

American Transplant Congress abstracts

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  • 2018 American Transplant Congress

    Factors Predicting Viability Achievement on Discarded Donor Livers Submitted to Extra-Corporeal Machine Perfusion

    Y. Boteon,1,2 R. Laing,1,2 A. Schlegel,2 J. Attard,1,2 L. Wallace,1 A. Smith,2 T. Perera,2 J. Isaac,2 D. Mirza,2 S. Afford,1 H. Mergental.2

    1National Institute for Health Research, Birmingham Liver Biomedical Research Centre, University of Birmingham, Institute of Immunology and Immunotherapy, Birmingham, United Kingdom; 2Liver Unit, Queen Elizabeth Hospital, University Hospitals Birmingham, Birmingham, United Kingdom.

    Background: Ex-vivo machine perfusion of livers (MP) may offer superior preservation for marginal donor organs. During normothermic machine perfusion (NMP) is possible to assess liver…
  • 2018 American Transplant Congress

    Comparison of Outcomes in African-American and White Primary Kidney Transplant Recipients: A Matched-Pair Analysis

    F. Tedla, A. Brar, D. John, N. Sumrani, R. Gruessner, A. Gruessner, M. Salifu.

    SUNY Downstate Medical Center, Brooklyn, NY.

    Background: Racial differences in clinical and sociodemographic characteristics have been well recognized. This study aims to assess outcomes in African-American (AA) and white primary deceased…
  • 2018 American Transplant Congress

    Change in Estimated Glomerular Filtration Rate Pre and Post Development of Donor-Specific Antibodies after Kidney Transplantation

    B. Ho,1 S. Montag,1,2 H. Bhagat,3 K. Atiemo,1 A. Daud,1 R. Kang,1 L. Zhao,1,2 J. Schwartz,3 D. Ladner.1

    1Northwestern University Transplant and Outcomes Research Collaborative (NUTORC), Chicago; 2Dept of Preventive Medicine, Northwestern University, Chicago; 3Astellas Pharma Global Development, Inc., Northbrook.

    Formation of de novo donor-specific antibodies (dnDSA) against human leukocyte antigens contributes to inferior kidney transplant (KT) outcomes. We assessed the effect of dnDSA on…
  • 2018 American Transplant Congress

    Characteristics and Outcomes of Kidney Transplant Recipients with More Than 25 Years of a Functioning Graft

    S. Parajuli, D. Mandelbrot, F. Aziz, N. Garg, M. Mohamed, B. Muth, B. Astor, A. Djamali.

    University of Wisconsin, Madison.

    Background: There is limited information on clinical characteristics and outcomes of kidney transplant recipients (KTRs) with more than 25 years of graft survival.Methods: We addressed…
  • 2018 American Transplant Congress

    Successful Utilization of Deceased Donor Kidney Allografts with KDPI>85: The Organ is Not Wholly to Blame

    A. Agarwal,1 A. Nishio Lucar,2 A. Nickkholgh,1 K. Brayman,1 A. Doyle,2 J. Oberholzer.1

    1Dept. of Surgery, University of Virginia Health System, Charlottesville, VA; 2Dept. of Internal Medicine, University of Virginia Health System, Charlottesville, VA.

    Background: High kidney donor profile index (KDPI)>85% organs are increasingly discarded, suggesting missed opportunities to provide patients the benefits of transplantation. Herein, we report the…
  • 2018 American Transplant Congress

    Donor Acute Kidney Injury Does Not Affect Fibrosis on 1 Year Post-Transplant Kidney Biopsy

    D. van der Windt, X. Chen, K. Lemon, C. Wu, N. Shah, R. Mehta, C. Puttarajappa, P. Sood, S. Hariharan, A. Ganoza, M. Wijkstrom, A. Humar, A. Tevar.

    Thomas E. Starzl Transplantation Institute, University of Pittsburgh Medical Center, Pittsburgh, PA.

    PurposeThe use of kidneys from deceased donors with acute kidney injury (AKI) at the time of donation is a potential method by which to expand…
  • 2018 American Transplant Congress

    Impact of Direct Antiviral Therapy for Hepatitis C on Acute Rejection and DSA Formation in Kidney Transplant Recipients

    Z. Zaky, S. Armanyous, L. Herlitz, E. Poggio, J. Augustine.

    Cleveland Clinic, Cleveland, OH.

    Background: Hepatitis C virus infection (HCV) has historically portended a poor outcome after kidney transplantation. With recent advent of direct antiviral agents (DAA), there has…
  • 2018 American Transplant Congress

    Use of Granulocyte Colony-Stimulating Factor for Leukopenia Post-Renal Transplant

    S. Hamel,1 V. Kuo,2 D. Johnson,1 R. Bloom,3 D. Sawinski,3 J. Trofe-Clark.1,3

    1Pharmacy, Hosp of Univ. of Pennsylvania, Philadelphia; 2Pharmacy, Univ. of California San Francisco, San Francisco; 3Renal Division, Perelman School of Medicine, Univ. of Pennsylvania, Philadelphia.

    Purpose: Leukopenia is a frequent complication in renal transplant recipients (RTRs). Granulocyte colony-stimulating factor (G-CSF) accelerates white blood cell (WBC) count recovery; but, published experience…
  • 2018 American Transplant Congress

    Prevalence of Metabolic Syndrome (MetS) and Insulin Resistance in Living Kidney Donors

    I. Agboli, L. Moore, D. Nguyen, E. Graviss, H. Ibrahim, A. Gaber, A. Sadhu.

    Houston Methodist Hospital, Houston, TX.

    Living kidney donors (LD) are routinely evaluated for components of MetS such as diabetes (T2D), hypertension (HTN), and hyperlipidemia (HLD). MetS is associated with T2D,…
  • 2018 American Transplant Congress

    Belatacept-Refractory CD8+CD28–CD38hi Effector/Memory T Cells Are Targeted by mTOR Inhibition Leading to a Preferential Loss of CD40L

    C. Castro Rojas,1 A. Godarova,1 A. Rike Shields,2 R. Alloway,2 M. Jordan,3 E. Woodle,2 D. Hildeman.1

    1Division of Immunobiology, Cincinnati Children's Hospital, University of Cincinnati College of Medicine, Cincinnati, OH; 2Division of Transplantation, University of Cincinnati College of Medicine, Cincinnati, OH; 3Division of Bone Marrow Transplant and Immune Deficiency, Cincinnati Children's Research Foundation, Cincinnati, OH.

    Calcineurin inhibitors (CNIs) and corticosteroids (CSS) have substantial untoward side effects, most notably nephrotoxicity. Consequently, the FDA approved belatacept for maintenance immunosuppression. We recently completed…
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