ATC Abstracts

American Transplant Congress abstracts

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  • 2018 American Transplant Congress

    Validation of Genetic Variants Identified in GWAS for Tacrolimus Troughs

    P. Jacobson,1 D. Schladt,2 W. Guan,3 J. van Setten,6 R. Remmel,4 B. Wu,3 C. Dorr,5 B. Keating,7 D. Ikle,9 R. Mannon,10 A. Matas,8 A. Israni,5 W. Oetting.1

    1Experimental and Clinical Pharmacology, Univ of MN, Minneapolis, MN; 2Chronic Disease Research Group, Minneapolis Medical Research Foundation, Hennepin County Medical Center, Minneapolis, MN; 3Division of Biostatistics, Univ of MN, Minneapolis, MN; 4Medicinal Chemistry, Univ of MN, Minneapolis, MN; 5Medicine, Hennepin County Medical Center, Minneapolis, MN; 6Cardiology, University Medical Center Utrecht, Utrecht, Netherlands; 7Surgery, Univ of Pennsylvania, Philadelphia, PA; 8Surgery, Univ of MN, Minneapolis, MN; 9Rho Inc, Chapel Hill, NC; 10Department of Medicine and Surgery, Univ of Alabama, Birmingham, AL.

    Purpose: Tacrolimus (TAC) is a substrate for CYP3A4/5 enzymes. It is well-known that variants in these genes are associated with variability in TAC trough concentrations.…
  • 2018 American Transplant Congress

    Belatacept and Tacrolimus Corticosteroid-Free Regimens Lead to Elevated Mycophenolic Acid Exposure at 1 and 3 Months after Kidney Transplantation

    A. Dao, S. Tremblay, A. Shields, A. Loethen, B. Abu Jawdeh, T. Diwan, A. Govil, E. Woodle, R. Alloway.

    UCincinnati, Cincinnati.

    Mycophenolate mofetil (MMF) is generally administered as a fixed dose. Studies have shown a relationship between MPA exposure (MPAAUC) but no data evaluates this relationship…
  • 2018 American Transplant Congress

    Immunosuppression Does Not Affect Adverse Pathological Outcomes in Men Who Underwent Radical Prostatectomy

    M. Eltemamy, A. Elshafei, Y. Nyame, A. Crane, A. Wee, V. Krishnamurthi, E. Klein, S. Jones.

    Cleveland Clinic, Cleveland.

    Introduction: The impact of imuunosuppression (IS) on biological aggressiveness of cancer prostate (PCa) is unclear. We aim to assess the adverse pathological (AP) outcomes in…
  • 2018 American Transplant Congress

    Racial/Ethnic Disparities in Living Donor Kidney Transplantation before and after the New National Kidney Allocation System

    X. Zhang,1 T. Melanson,2 L. Plantinga,3,6 M. Basu,1 S. Pastan,1,7 S. Mohan,4,5 M. Garber,6 R. Patzer.1,6,7

    1Department of Surgery, Emory University School of Medicine, Atlanta; 2Department of Health Policy & Management, Emory University, Atlanta; 3Department of Medicine, Emory University School of Medicine, Atlanta; 4School of Medicine, Columbia University, New York; 5Department of Epidemiology, Columbia University, New York; 6Department of Epidemiology, Emory University, Atlanta; 7Emory Transplant Center, Emory Healthcare, Atlanta.

    We aimed to assess the potential unintended impact of a new national kidney allocation system (KAS) in December 2014 on living donor kidney transplant (LDKT)…
  • 2018 American Transplant Congress

    Spigelius' Line Incision as a Successful Route to Extract the Kidney during Retroperitoneal Laparoscopic Live-Donor Nephrectomy

    J. Qiu, G. Chen, Z. Wu, C. Wang, L. Chen.

    Organ Transplantation, The First Affiliated Hospital of Sun Yet-sen University, Guangzhou, Guangdong, China.

    To introduce the advantages, incision designing methods and surgical procedures of spigelius' line incision in retroperitoneal laparoscopic living donor nephrectomy.Methods: The clinical data of 114…
  • 2018 American Transplant Congress

    Enhanced Recovery after Renal Transplant Surgery Using a Transversus Abdominis Plane Block is Associated with Decreased Hospital Length of Stay

    D. Peramunage, D. Auyong, C. Kuhr, J. Brandenberger, N. Cowan, N. Hanson.

    Virginia Mason Medical Center, Seattle, WA.

    BACKGROUNDThe transversus abdominis plane (TAP) block reduces pain and opioid consumption following renal transplant surgery, but its impact on hospital length of stay (LOS) remains…
  • 2018 American Transplant Congress

    Impact of an Anastomosis Time on Transplant Outcomes in Deceased Donor Kidney Transplantation

    K. Jeong, H. Jung, J. Choi, J-.H. Lim, J. Choi, J-.H. Cho, S-.H. Park, Y-.L. Kim, C-.D. Kim.

    Internal Medicine, Kyungpook National University School of Medicine, Daegu, Republic of Korea.

    Background: It is known that the increase in anastomosis time (AT) in deceased donor kidney transplantation (DDKT) is associated with increased incidence of delayed graft…
  • 2018 American Transplant Congress

    mTOR Inhibitor Based Immunosuppression Regimens Are Not Associated with Lower Risk for BK Infection

    R. Daloul,1 R. Pelletier,2 A. Rajab,2 G. Bumgardner,2 M. Alebrahim,2 C. Akateh,3 K. Washburn,2 A. El-Hinnawi.2

    1Nephrology, The Ohio State University Wexner Medical Center, Columbus, OH; 2Transplant Surgery, The Ohio State University Wexner Medical Center, Columbus, OH; 3Surgery, The Ohio State University Wexner Medical Center, Columbus, OH.

    Introduction: BK virus continues to be a significant post-transplant complication with increasing incidence in the current era of potent immunosuppression. Mammalian target of rapamycin inhibitors…
  • 2018 American Transplant Congress

    Incidence of BK Viraemia and BK Virus Associated Nephropathy with Standard vs. Augmented Immunosuppression

    R. Rathore, S. Anastassiadou, A. Kaur, J. Timms, N. Krishnan.

    Renal Transplant, University Hospitals of Coventry and Warwickshire, Coventry, United Kingdom.

    Introduction:It has been long established that over-immunosuppressed state leads to BK virus reactivation. BK viraemia (BKV) can progress to BK virus associated nephropathy (BKVAN) which…
  • 2018 American Transplant Congress

    Ethnic and Age Disparities in Outcomes among Liver Transplant Waitlist Candidates

    M. Mustian,1 S. Gray,1 B. Shelton,1 R. Reed,1 P. MacLennan,1 J. White,1 D. Eckhoff,1 R. Allman,2 J. Locke.1

    1University of Alabama at Birmingham, Birmingham; 2Department of Veterans Affairs, Washington DC.

    Background: Despite the increasing prevalence of end-stage liver disease (ESLD) in older adults, there is no consensus to determine suitability for liver transplantation (LT) in…
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