2018 American Transplant Congress
Hospitalization and Life Support before Liver Transplantation – Easily Available Predictors for Post-Transplant Patient Survival
IntroductionCurrently liver allocation -in contrast to allocation of other organs- is based on urgency in many countries and survival benefit is not included. Aim of…2018 American Transplant Congress
Clinical Utility of CMV-Specific CD8+ T-Cell Immune Competence Score in Lung and Heart-Lung Transplant Recipients at Risk of Cytomegalovirus Infection
Introduction: Cytomegalovirus (CMV) is a common infection that causes significant morbidity among lung and heart-lung (LHL) transplant recipients. We determined the clinical utility of global…2018 American Transplant Congress
Successful Desensitization with Carfilzomib-Based Regimen to Facilitate Lung Transplantation: Initial Experience
1University of Pittsburgh, Pittsburgh, PA; 2Temple University, Philadelphia, PA.
Purpose:We describe the successful desensitization of highly sensitized lung transplant candidates (LTCs) using plasma exchange (PLEX),intravenous immunoglobulin G(IVIg),and carfilzomib.Methods:5-patient case series of successful desensitization of…2018 American Transplant Congress
Preventing of Rejection of Vascularized Composite Allografts by Targeting T Cell Metabolism
[Background] Upon antigen recognition and co-stimulation, T lymphocytes upregulate the metabolic machinery necessary to proliferate and sustain effector function. This metabolic reprogramming in T cells…2018 American Transplant Congress
Evaluation of the Use of Oral Valganciclovir for the Treatment of Cytomegalovirus Infections in Pediatric Intestinal Transplant Recipients: A Single Center Review
Purpose: To evaluate the safety and efficacy of oral valganciclovir in treating cytomegalovirus (CMV) infections in pediatric intestinal transplant recipients (pITR).Methods: This retrospective review included…2018 American Transplant Congress
Impact of Influenza Vaccine Implementation by Transplant Pharmacy in Solid Organ Transplant Recipients
1Children's Healthcare of Atlanta, Atlanta, GA; 2Emory University School of Medicine, Atlanta, GA.
Background: In solid organ transplant (SOT) recipients, influenza infection can lead to subsequent graft dysfunction and mortality. In an effort to increase vaccination rates, transplant…2018 American Transplant Congress
Bacterial Complications in Liver Transplant Recipients Undergoing Biliary Tract Manipulation: Effect of an Antibiotic Prophylaxis Protocol
University of Massachusetts Medical School, Worcester, MA.
Purpose: The purpose of this study was to evaluate incidence of bacteremia and outcomes in liver transplant recipients that had biliary tract manipulation before and…2018 American Transplant Congress
In Vivo Administration of Plerixafor and Bortezomib Results in Bone Marrow Plasma Cell Mobilization and Death While Inducing Biphasic Plasma Cell Apoptosis in Peripheral Blood
1U Cincinnati, Cincinnati; 2Cincinnati Children's, Cincinnati; 3Duke, Durham.
Bone marrow (BM) plasma cells (PC) secreting HLA antibody (Ab) remain a persistent reservoir of donor specific Ab and present a significant hurdle to allograft…2018 American Transplant Congress
Potential Impact of DCD Donor Recoveries on Heart Transplantation: Retrospective Analysis of a Limited UNOS Dataset
Purpose: To review the volume and quality of potential DCD (Donation after Cardiac Death) Heart Transplant (HT) donors in the US, evaluate trends over time…2018 American Transplant Congress
Evaluation of Drug Action on IgM Memory B Cell Survival and Growth In Vitro; -Application for Individualized Immunosuppression after Kidney Transplants-
(Background)Recently, the establishment of early diagnosis and treatment methods for antibody-mediated rejection (ABMR) has garnered much attention.Strong immunosuppression including desensitization is accompanied by severe side…
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