2018 American Transplant Congress
Acute Tubular and Glomerular Kidney Injury Markers Reflect Ischemia-Reperfusion and Rejection
Immunology, Cleveland Clinic, Cleveland, OH.
Reliable markers of early acute injury following renal transplantation would enable timely therapeutic interventions. Standard serum creatinine and blood urea nitrogen measurements increase only after…2018 American Transplant Congress
Multiple Factors Contribute to an Expanded Immune Risk Profile in Pre Renal Transplant Candidates
1Medicine, Beth Israel Deaconess Medical Center, Boston, MA; 2Viracor-Eurofins, Lee's Summmit, MO.
Introduction: Older renal transplant recipients have a lower risk of rejection, but are at increased risk for infectious complications. An immune risk profile (IRP) has…2018 American Transplant Congress
Involvement of Aldehyde Dehydrogenase 2 (ALDH2) in Fatty Liver Graft Protection Mechanisms against Cold Ischemic Injury
Aldehyde dehydogenase (ALDH2) is a mitochondrial enzyme that recently has been involved in the cardioprotection against ischemia injury. No data are reported on the potential…2018 American Transplant Congress
Dynamics of CD25-Positive Myeloid Suppressor Cells in Solid Organ Transplanted Patients and Relationship with Rejection
Background: Myeloid derived suppressor cells (MDSC) are immature cells with immunosuppressive capacities. Three MDSC subsets are currently defined: monocytic, early stage, and polymorphonuclear MDSC (M-MDSC,…2018 American Transplant Congress
Leukocytes from Recipients with Severe Primary Graft Dysfunction after Lung Transplant Adoptively Transfer Alloreactivity to Vessel Grafts Trans Vivo
1HTTG, MHH, Hannover, Germany; 2Transplantimmunology, MHH, Hannover, Germany.
Introduction: Primary graft dysfunction (PGD) is the main cause of early mortality after lung transplantation (LTx). Multiple mechanisms have been described, but the link between…2018 American Transplant Congress
Hyperglycemia-Triggered S1P/SIPR3signaling Exacerbates Liver Ischemia/Reperfusion Injury by Regulating M1/M2 Polarization
Background and Aims: Hyperglycemia/Diabetes is an adverse risk factor for hepatic ischemia/reperfusion injury (IRI) during liver transplantation or hepatectomy; however, the underlying mechanism remains unclear.Sphingosine…2018 American Transplant Congress
Urinary C-X-C Motif Chemokines 13 is a Noninvasive Biomarker of Antibody-Mediated Renal Allograft Rejection
Background: Since acute rejection remains one of the major complications which necessitate periodic surveillance, noninvasive diagnostic/prognostic methods are preferred by renal transplant recipients. Here we…2018 American Transplant Congress
Waning Enthusiasm for a Once Promising Test: C1q Testing Does Not Provide Prognostic Information for DSA Screening Protocols
Medstar Georgetown Transplant Institute, Medstar Georgetown University Hospital, Washington, DC.
Introduction: Testing of donor specific antibodies (DSA) for binding of complement component C1q has been used to better elucidate pathologic antibodies from more benign reactions.…2018 American Transplant Congress
ABO-Incompatibility Lower Incidence of DSA-Induced Antibody-Mediated Rejection
Introduction:Donor-specific anti-HLA antibody (DSA) and Anti-ABO antibody are major barriers for successful kidney transplantation. Limited data are available about the existences of both DSA and…2018 American Transplant Congress
Delayed Graft Function in Live Donor HLA-Incompatible Kidney Transplant Recipients: A Multicenter Study
1JHU, Baltimore; 2UCSF, San Francisco.
Background: Many patients with a willing, but incompatible live donor choose to undergo incompatible live donor kidney transplantation (ILDKT) facilitated by desensitization procedures to eliminate…
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