ATC Abstracts

American Transplant Congress abstracts

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  • 2018 American Transplant Congress

    Identification of Macrophage Innate Receptors in Recognition and Rejection of Allogeneic Non-Self in Transplantation

    P. Lan,1 H. Dai,2 W. Liu,1 S. Chen,1 L. Minze,1 Y. Dou,1 Y. Zhao,1 W. Chen,1 X. Xiao,1 P. Pan,1 H-.H. Chen,1 F. Lakkis,2 X. Li.1

    1Immunobiology and Transplant Science Center, Houston Methodist Research Institute, Houston, TX; 2Starzl Transplantation Institute, University of Pittsburgh, Pittsburgh, PA.

    Recent studies in several labs provide compelling evidence that the innate immune cells can recognize and reject allogeneic non-self in an antigen-specific manner, but the…
  • 2018 American Transplant Congress

    Non-Invasive Proteomics to Detect Biomarkers for Kidney Allograft Dysfunction

    M. Watson,1 M. Srivastava,3 D. Little,1 O. Eidelman,3 R. Nee,1 A. Bera,3 J. Karaian,3 D. Oliver,1 H. Pollard,3 R. Jindal.2

    1Nephrology, USU-Walter Reed, Bethesda, MD; 2Surgery, USU-Walter Reed, Bethesda, MD; 3Anamtomy, Physiology and Genetics, USU-School of Medicine, Bethesda, MD.

    Background: Non-invasive biomarkers are needed for monitoring patients to predict early acute rejection (AR). We hypothesized that protein biomarkers released from rejecting allograft tissues can…
  • 2018 American Transplant Congress

    Intragraft MicroRNA Transcriptome of Acute Antibody Mediated Rejection of Human Kidney Allografts

    H. Yang,1 K. Akat,2 C. Li,1 C. Snopkowski,1 Z. Khan,1 D. Dadhania,1 T. Tuschl,2 M. Suthanthiran,1 T. Muthukumar.1

    1Weill Cornell Medicine, New York; 2Rockefeller University, New York.

    BackgroundMicroRNAs (miRNA) are master regulators of gene expression and are potential therapeutic targets. Intragraft miRNA transcriptome of acute antibody rejection (AMR) of human kidney allograft…
  • 2018 American Transplant Congress

    Identification of Exosomal Proteins from Human Lung Transplant Recipients

    S. Bansal,1 P. Pirrotte,2 M. Saltzman,2 K. Garcia,2 M. Sharma,1 M. Gunasekaran,1 M. Smith,1 R. Bremner,1 T. Mohanakumar.1

    1Norton Thoracic Institute, St. Joseph's Hospital & Medical Center, Phoenix; 2Collaborative Center for Translational Mass Spectrophotometry Translational Genomics Research Institute, Phoenix.

    Molecular mechanisms involved in rejection following human lung transplantation are not well understood. Goal of this study is to identify proteomic signatures in the circulating…
  • 2018 American Transplant Congress

    Changes in Phenotype, Immune Suppressive, Function, and Gene Expression of Myeloid Derived Suppressor Cells in Patients Given Combined Kidney and Hematopoietic Cell Transplants in a Tolerance Protocol

    K. Jensen,1 P. Zheng,2 J. Xuhuai,2 A. Saraswathula,1 J. Scandling,3 S. Busque,4 J. Shizuru,5 R. Lowsky,5 A. Shori,4 H. Maecker,2 E. Engleman,1 E. Meyer,5 S. Strober.1

    1Immunology, Stanford School of Medicine, Stanford, CA; 2Human Immune Monitoring Center, Stanford School of Medicine, Stanford, CA; 3Nephrology, Stanford School of Medicine, Stanford, CA; 4Surgery, Stanford School of Medicine, Stanford, CA; 5Blood & Marrow Transplantation, Stanford School of Medicine, Stanford, CA.

    Tolerance induction after combined organ and hematopoietic cell transplantation can be achieved using conditioning with total lymphoid irradiation (TLI) and anti-thymocyte globulin (ATG), in both…
  • 2018 American Transplant Congress

    TGR5-Mediated AMPK/mTOR Signaling Regulates Macrophage Migration and Polarization in Liver Ischemia Reperfusion

    S. Zhou, H. Zhou, R. Liu, F. Zhang, X. Wang, L. Lu.

    Liver Transplantation Center, First Affiliated Hospital, Nanjing Medical University, Nanjing, Jiangsu, China.

    Background: Although the plasma membrane-bound G protein–coupled bile acid receptor (TGR5) exerts protective roles in various inflammatory diseases, little is known about the effects and…
  • 2018 American Transplant Congress

    The Role of NKT Cell /IL-17 Axis in the Autoimmune Lupus Nephritis

    J. An,1 Y. Kim,2 M. Yu,2 J. Lee,1 C. Lee,3 Y. Kim,2 S. Yang.4

    1Internal Medicine, Boramae Medical Center, Seoul, Korea; 2Internal Medicine, Seoul National University Hospital, Seoul, Korea; 3Internal Medicine, Cheju Halla General Hospital, Cheju, Korea; 4Internal Medicine, Seoul National University Kidney Research Institute, Seoul, Korea.

    CD1d-restrictive NKT cells may modulate various chronic autoimmunity through secreting multiple cytokines, but the functional relationships between the different subpopulation still are poorly understood. The…
  • 2018 American Transplant Congress

    Eculizumab for the Treatment of Antibody Mediated Rejection in Kidney Transplant Recipients: A Single Center Experience

    A. Chi, J. Phillips, D. Quan.

    Pharmaceutical Services, UCSF Medical Center, San Francisco, CA.

    BACKGROUND: Antibody mediated rejection (ABMR) accounts for 20-30% of acute rejection episodes and can affect long-term renal allograft survival. The complement system plays an active…
  • 2018 American Transplant Congress

    Efficacy and Safety of Tocilizumab in Treatment of Acute Antibody Mediated Rejection

    K. Venkatachalam, D. Reem, M. Andrew, R. Delos Santos, T. Alhamad.

    Transplant Nephrology, Washington University, Saint Louis, MO; Transplant Nephrology, Ohio State University, Columbus, OH; Transplant Nephrology, Washington University, Saint Louis, MO; Transplant Nephrology, Washington University, Saint Louis, MO.

    Antibody mediated rejection continues to be one of the most detrimental complications of kidney transplant. Multiple therapeutic strategies focused on B cell and/or HLA antibody…
  • 2018 American Transplant Congress

    Single Center Experience in Use of Check Point Inhibitors and Outcomes in Kidney Transplant Recipients

    K. Venkatachalam, R. Delos Santos, T. Alhamad.

    Transplant Nephrology, Washington University, St. Louis, MO; Transplant Nephrology, Washington University, St. Louis, MO.

    Organ transplant recipients who are on lifelong immunosuppressive agents are those who are at increased risk of malignancies (excess absolute risk of 719 cases per…
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