2018 American Transplant Congress
Everolimus with Reduced Calcineurin Inhibitor Exposure in De Novo Kidney Transplant Recipients: Efficacy and Safety Outcomes from the TRANSFORM Study
1TRANSFORM Study Group, Livingston; 2Novartis Pharma AG, Basel, Switzerland.
Purpose: Everolimus (EVR)-facilitated calcineurin inhibitor (CNI) reduction regimens help prevent long-term CNI nephrotoxicity in kidney transplant recipients (KTxRs). TRANSFORM (NCT01950819) is the largest study in…2018 American Transplant Congress
Circulating Follicular Helper T Cells (cTfh) in Renal Transplantation: Utility as Rejection Biomarker
Introduction: Antibody (Ab) mediated rejection is responsible for 30-50% of renal graft failures. Follicular helper T cells (Tfh) are required for the differentiation of B…2018 American Transplant Congress
DNA Methylation Age and Differential Patterns of DNA Methylation in Older Compared with Younger Kidney Transplant Recipients
David Geffen School of Medicine at UCLA, Los Angeles, CA.
Introduction: Older transplant recipients experience increased rates of infection and death, but decreased rates of rejection, suggesting a role of immune dysfunction. Analysis of DNA…2018 American Transplant Congress
AT1R Antibody Analysis: High Proportion of Non-Specific Reactivity?
INTRODUCTION:The angiotensin II type 1 receptor (AT1R) is expressed on vascular endothelium. AT1R antibodies (Ab) have been studied to examine their relevance in renal and…2018 American Transplant Congress
Whole-Transcriptome Sequencing to Identify Macaque Immune Gene Variants
Macaque monkeys are critical in transplantation studies, yet macaque genomics lags significantly behind human genomics. While reliable genotyping methods have been developed for some macaque…2018 American Transplant Congress
Soluble Fibrinogen-Like Protein 2 Regulates Myeloid-Derived Suppressor Cells Differentiation and Enhances Its Immunosuppressive Function of in Allograft Immunity
Urology, Zhongshan Hospital, Fudan University, Shanghai, China.
Soluble fibrinogen-like protein 2 (sFGL2) is a novel immunoregulatory molecule, secreted mainly by regulatory T cells. CD11b+ Gr1+ myeloid-derived suppressor cells (MDSCs) are an important…2018 American Transplant Congress
Influence of X-Ray Repair Cross-Complementing Group (XRCC) Genes Polymorphisms on the Development of Antibody-Mediated Rejection (ABMR) in Renal Transplant Recipients
The importance of antibody-mediated rejection (ABMR) on the renal transplant recipients has been recognized in recent years. However, the pathogenesis of ABMR following kidney transplantation…2018 American Transplant Congress
Eluates from Fine-Needle Allograft Biopsy Increase Donor-Specific Antibody Identification in Antibody Mediated Rejection
1University of Cincinnati, Cincinnati; 2Hoxworth Blood Center, Cincinnati.
Aim. Antibody mediated rejection (AMR) represents a risk for graft loss, and the presence of circulating donor-specific antibody (cDSA) is a major criterion for AMR…2018 American Transplant Congress
Impact of De Novo DSA (DnDSA) on Outcomes in HLA-Sensitized (HS) Patients Transplanted after IVIG + Rituximab Desensitization (DES)
Introduction: Highly-HLA sensitized patients (HS) with donor specific antibodies (DSA) at transplant are at risk for Type 1 ABMR. However, the incidence of Type 2…2018 American Transplant Congress
Impact of Bw4 and Bw6 Epitope Mismatch on Clinical Outcomes after Renal Transplantation
HLA class II epitope mismatch has been shown to impact the long-term survival of kidney allografts. HLA-B alleles are traditionally grouped by the Bw4 and…
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