Am J Transplant, Volume 18, Suppl 3 Archives - Page 201 of 211 - ATC Abstracts

2018 American Transplant Congress
The Impact of Childhood Solid Organ Transplantation on B-Cell Maturation
L. Ionescu,¹ T. Blydt-Hansen,² B. Foster,⁷ S. Mital,³ L. Hamiwka,⁵ U. Allan,³ V. Phan,⁴ P. Birk,⁶ C. Morgan,¹ S. Urschel.¹
¹U of Alberta, Edmonton, Canada; ²U of BC, Vancouver, Canada; ³Hospital for Sick Children, Toronto, Canada; ⁴U de Montreal, Montreal, Canada; ⁵U of Calgary, Calgary, Canada; ⁶U of Manitoba, Winnipeg, Canada; ⁷McGill University, Montreal, Canada.
Background:The developing immune system of childhood promotes better graft acceptance and longevity but also higher risk for infections and post-transplant (Tx) lymphoproliferative disorders. This may…
2018 American Transplant Congress
C3a Receptor Regulates the CD8 T-Cell Alloresponse via Intrinsic and Extrinsic Mechanisms
J. Horwitz, D. Mathern, P. Heeger.
Icahn School of Medicine at Mount Sinai, NY, NY.
The role of complement in solid organ transplantation continues to evolve with our enhanced understanding of complement's regulation of the alloresponse. Prior work has shown…
2018 American Transplant Congress
NK Cells with a Lung-Resident Phenotype Represent the Most Prominent Donor Passenger Leukocyte Subset after Clinical Lung Transplantation
C. Falk,¹ R. BellmasSanz,¹ B. Wiegmann,² A-.M. Hitz,¹ K. Bläsing,¹ C. Neudörfl,¹ I. Tudorache,² C. Kühn,² M. Avsar,² A. Haverich,² G. Warnecke.²
¹Institute of Transplant Immunology, IFB-Tx, Hannover Medical School, Hannover, Germany; ²Department of Cardiothoracic, Transplantation and Vascular Surgery, Hannover Medical School, Hannover, Germany.
ObjectivesDonor passenger leukocytes in peripheral blood of recipients after lung transplantation have been described long time ago. However, kinetics, distribution of T vs. NK cells,…
2018 American Transplant Congress
Validation Study of Gene Expression Signatures Associated with Antibody-Mediated Rejection (ABMR) and Cell-Mediated Rejection (CMR) in Renal Allograft Biopsies (Bx) Suggests Complexity of Molecular Diagnosis for ABMR Compared to CMR
H. Zhang,¹ C. Nast,² J. Doldron,² M. Cheung,² A. Vo,³ S. Jordan,³ M. Toyoda.¹
¹Transplant Immunology Laboratory, Cedars-Sinai Medical Center, Los Angeles, CA; ²Pathology, Cedars-Sinai Medical Center, Los Angeles, CA; ³Comprehensive Transplant Center, Cedars-Sinai Medical Center, Los Angeles, CA.
Background: Various molecular signatures specific to ABMR and CMR based on gene expression in renal allograft Bx or peripheral blood mononuclear cells (PBMC) of renal…
2018 American Transplant Congress
Clinical Significance of Microvascular Inflammation in the Absence of Anti-HLA DSA in Kidney Transplantation
S. Parajuli, R. Redfield, F. Aziz, N. Garg, M. Mohamed, W. Zhong, T. Ellis, A. Djamali, D. Mandelbrot.
University of Wisconsin, Madison.
Background: It is not uncommon to have biopsy specimens meeting Banff glomerulitis (g) plus peritubular capillaritis (ptc) and/or c4d scores that meet criteria for antibody…
2018 American Transplant Congress
Impact of Pretransplant Donor-Specific Antibodies on Kidney Allograft Recipients with Negative Flow Cytometry Crossmatches
H. Kwon, Y. Kim, J. Choi, S. Shin, J. Jung, M. Cho, J. Kim, D. Han.
Asan Medical Center, Seoul, Korea.
This study evaluated the impact of DSA on clinical outcomes in KT recipients negative on FCXM. Of 575 consecutive patients who underwent living donor KT…
2018 American Transplant Congress
A Substantial Fraction of Surveillance Transplant Biopsies Have Clinically Actionable Findings
A. Shammout,¹ A. Naik,² M. Samaniego,² E. Farkash.¹
¹Pathology, Michigan Medicine, Ann Arbor; ²Nephrology, Michigan Medicine, Ann Arbor.
Background: Surveillance biopsies in renal transplant recipients may detect subclinical disease that affects graft longevity. At our transplant center, most patients with stable allograft function…
2018 American Transplant Congress
Interactive Software for Simulation and Management of a Kidney Paired Donation Program
M. Bray,¹ W. Wang,¹ M. Rees,² P. Song,¹ A. Leichtman,³ V. Ashby,¹ J. Kalbfleisch.¹
¹University of Michigan, Ann Arbor, MI; ²Alliance for Paired Donation, Maumee, OH; ³Arbor Research, Ann Arbor, MI.
In kidney paired donation (KPD), candidates with willing but incompatible donors are pooled together with the goal of finding new transplant opportunities by exchanging donors.…
2018 American Transplant Congress
Cause of ESRD is Not Associated with Risk of Post-Transplant CMV Infection
S. Panzer, S. Peery, B. Astor, A. Djamali, T. Singh.
University of Wisconsin Madison, Madison, WI.
Purpose: Cytomegalovirus (CMV) infection is commonly encountered following kidney transplantation and is associated with patient morbidity and mortality. While preventative pharmacotherapy is used to prevent…
2018 American Transplant Congress
Outcomes of Kidney Transplantation from HBsAg Positive Donors to HBsAb Positive Recipients
G. Chen, C. Wang, Z. Wu, X. Liu, C. Wang, L. Chen.
Organ Transplant Center, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong, China.
Objective To investigate the outcomes of transplanting kidneys from HBsAg positive donors to HBsAb positive recipients.Methods We retrospectively collected data of 57 kidney transplants from…