2018 American Transplant Congress
Unbiased Sequencing of Urine Cell-Free DNA (cfDNA) to Evaluation Urine Virome and Associated Renal Allograft Damage
Intro: Virus reactivation leading to graft damage is a frequent post-kidney transplant (KTx) complication. Immunosuppressed individuals are at risk for multiple virus infections simultaneously. Current…2018 American Transplant Congress
All DQ DSA May Not Be Equal: Comparing Outcomes between De Novo DQ DSA Specificities
It is not known if development of de novo DSA (dnDSA) to different HLA-DQ mismatches (serological) are associated with equal risk to a patient's allograft…2018 American Transplant Congress
National Study of Living Donor Program Protocols, Processes, and Resources within U.S. Transplant Centers
Purpose: There is limited research that describes living donor (LD) program processes and protocols. This study aimed to describe LD program protocols, processes, and resources…2018 American Transplant Congress
HLA-DR4 Matching and Hepatocellular Carcinoma Recurrence after Liver Transplantation
PURPOSE: The phenomenon of graft versus host disease after orthotopic liver transplantation (OLT) is estimated at approximately 1-2%, suggesting that under some circumstances, the graft…2018 American Transplant Congress
TORC1 Inhibition Protects Activated Human Regulatory T Cells from Self-Inflicted Damage via Granzyme B
Transplantation Research Center, BWH, Harvard Medical School, Boston, MA.
The safety and efficacy of adoptive transfer of regulatory T cells (Tregs) are being extensively investigated in ongoing clinical trials. However, these trials have been…2018 American Transplant Congress
Improving the Organ Donation Referral Process through Telemedicine
1LiveOnNY, NY; 2Northwell Health, New Hyde Park.
Development of a Tele-ICU serving multiple institutions within our donor service area stimulated a collaborative performance improvement project. To improve the referral and timeliness rates…2018 American Transplant Congress
Role of B Cell Intrinsic NLRP3 in the Development of Chronic Rejection
Endogenous DAMPs elicited during transplantation are recognized via TLR-MyD88 and NLRP3-inflammosome pathways that are expressed in APCs including B cells. Here, we asked whether B…2018 American Transplant Congress
Intragraft MicroRNAs Foretell Fibrosis in Kidney Transplant Recipients
BackgroundIdentifying biomarkers that anticipate tubulointerstitial fibrosis (IFTA) of the kidney allograft will be a transformative advance.Aim/HypothesisIntragraft microRNA profile of 3-month surveillance biopsies reported as normal…2018 American Transplant Congress
Clinical Significance and Therapeutic Potential of Orosomucoid 1 for Chronic Active Antibody Mediated Rejection in Kidney Transplant Recipients
［Background］We reported a molecular mechanism to develop chronic inflammation (CI), called the inflammation amplifier (IA). IA is activated by concomitant activation of NFkB and STAT3…2018 American Transplant Congress
Long-Term HIF-1α Stabilization is Associated with Fibrosis in Rat Lung Allografts
Introduction: HIF-1α is a subunit of a heterodimeric transcription factor hypoxia-inducible factor 1 (HIF-1) and functions as a master transcriptional regulator of cellular and developmental…
American Transplant Congress abstracts