ATC Abstracts

American Transplant Congress abstracts

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  • 2018 American Transplant Congress

    Ischemia Reperfusion Injury in Liver Transplantation is Associated with Acute Kidney Injury: Role of Inflammatory Mediators

    P. Mihaylov,1,2 P. Li,1 J. Skill,1 L. Timsina,1 J. Fridell,1 B. Ekser,1 R. Mangus,1 C. Kubal.1

    1Surgery, Indiana University, Indianapolis; 2Surgery, University of Pavia, Pavia, Italy.

    Background: The impact of liver allograft ischemia/reperfusion injury (IRI) on native renal function remains to be characterized. We hypothesized that elevated levels of circulating inflammatory…
  • 2018 American Transplant Congress

    Screening of RhoA/ROCK Inhibitors for the Ability to Prevent Chronic Rejection of Mouse Cardiac Allografts

    W. Chen, W. Chen, X. Li, R. Ghobrial, M. Kloc.

    THMRI, Houston, TX.

    Objectives. Chronic rejection of transplanted organs is a major obstacle in human organ transplantation. Although the mechanisms of chronic rejection are poorly understood it is…
  • 2018 American Transplant Congress

    Ex Vivo Expanded Regulatory B Cells Promote Allograft Survival through IL-10-Dependent Pathway

    K. Lee, K. Deng, L. Kojima, C. Dai, C. Rickert, H. Yeh, J. Markmann.

    Massachusetts General Hospital, Boston.

    Immunomodulatory capacity of B cells make them a promising therapeutic tool for autoimmune and alloimmune response in patients. We found that transplant tolerance induced by…
  • 2018 American Transplant Congress

    Recombinant Relaxin Protects Liver Transplants from Ischemia-Reperfusion Damage via Hepatocyte Glucocorticoid Receptor: From Bench-to-Bedside

    S. Kageyama,1 K. Nakamura,1 T. Ito,1 A. Aziz,1 B. Ke,1 R. Sossa,2 E. Reed,2 F. Kaldas,1 R. Busuttil,1 J. Kupiec-Weglinski.1

    1Surgery, Division of Liver Transplantation, UCLA, Los Angeles, CA; 2Pathology, UCLA, Los Angeles, CA.

    Hepatic ischemia-reperfusion injury (IRI) represents a major risk factor of early graft dysfunction and acute/chronic rejection as well as a key obstacle to expanding the…
  • 2018 American Transplant Congress

    Decreased Long-Term Survival with Antithymocyte Globulin Induction in Elderly Kidney Transplant Recipients

    I. Bajjoka, A. Yaldo, C. Crombez, M. Abouljoud.

    Henry Ford Transplant Institute, Detroit, MI.

    Purpose: Long-term consequences of immunosuppression on the elderly is still unclear. This data to evaluates long-term outcomes for younger (Y) versus elderly (E) kidney transplant…
  • 2018 American Transplant Congress

    Non-Medical Factors Predict Receipt and Type of Kidney Transplant in Veterans

    K. Kendall, X. Li, C.-C. Chang, J. Pleis, E. Croswell, M. Dew, G. Switzer, A. Langone, A. Mittal-Henkle, S. Saha, M. Ramkumar, J. Adams-Flohr, C. Thomas, L. Myaskovsky.

    VA Kidney Transplant Centers: IA, OR, PA, TN, Iowa City, Portland, Pittsburgh, Nashville.

    Background: African Americans, Hispanic Americans and other minorities have a higher incidence of end-stage kidney disease but lower rates of both deceased and living donor…
  • 2018 American Transplant Congress

    Outcomes of Pregnancies in Female Liver Transplant Recipients

    L. Coscia,1 D. Armenti,1 P. Patel,2 S. Constantinescu,1,3 M. Moritz.1,2,4

    1Transplant Pregnancy Registry International, Gift of Life Institute, Philadelphia, PA; 2Surgery, Lehigh Valley Health Network, Allentown, PA; 3Medicine, Lewis Katz School of Medicine, Temple University, Philadelphia, PA; 4Surgery, Morsani College of Medicine, Tampa, FL.

    The purpose of this study is to describe 544 pregnancies in 278 liver transplant recipients reporting to the Transplant Pregnancy Registry International (TPR) from 1991…
  • 2018 American Transplant Congress

    Enrichment of Endogenous Donor-Reactive Tregs in the Spleen and Graft during Transplantation Tolerance is the Result of Treg Proliferation and Conversion from Tconv

    J. Young, D. Yin, M-.L. Alegre, A. Chong.

    Surgery and Medicine, University of Chicago, Chicago, IL.

    Foxp3+ regulatory T cells (Tregs) are critical mediators of immune tolerance and are absolutely required for allograft tolerance in animal models. In addition, clinical trials…
  • 2018 American Transplant Congress

    Cancer Incidence after Kidney Transplantation in Saudi Arabia, Comparing Different Induction Agents

    H. AlEid, S. Raza, T. Ali, I. Alahmadi, S. Aleid, D. Broering.

    Kidney and Pancreas Transplantation, King Faisal Specialist Hospital, Riyadh, Saudi Arabia.

    Cancer incidence varies among different induction agents and different population. We aim to compare the incidence of cancer post kidney transplantation among different induction agents…
  • 2018 American Transplant Congress

    De Novo DSA against Third Party Extension Vessels Used in Kidney and Pancreas Transplantation

    N. Garg, T. Ellis, R. Redfield, S. Parajuli, B. Astor, A. Djamali, D. Mandelbrot.

    University of Wisconsin, Madison.

    Third party ABO-compatible vessel allografts (VA) are sometimes used as extension vessels for kidney and pancreas transplants (TX). The frequency and implications of de novo…
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