ATC Abstracts

American Transplant Congress abstracts

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  • 2018 American Transplant Congress

    Mitigating Risk: Post-Exposure Prophylaxis in Liver Transplant Recipients from Donors with Potential Infectious Exposure

    A. Nolan, D. Yarosh, S. Shaikh.

    Department of Pharmacy, Medstar Georgetown University Hospital, Washington, DC.

    Purpose: Increased risk organ donors are being more commonly utilized given organ shortages. However, there is a small risk of transmission of diseases such as…
  • 2018 American Transplant Congress

    Impact of Positive Donor Blood Cultures in Liver Transplant Recipients

    D. Bley, D. Lo, G. Lyon III, R. Subramanian, S. Todd.

    Emory University Hospital, Atlanta, GA.

    The purpose of this study was to describe the bacteremia transmission rate of transplanting livers from donors with positive bacterial blood cultures into liver transplant…
  • 2018 American Transplant Congress

    Treatment of Multi-Drug Resistant Gram Negative Infections after Solid Organ Transplant

    M. Heldman, B. Nelson, T. Babu, M. Ison.

    Comprehensive Transplant Center, Northwestern University, Chicago, IL.

    Introduction: Infections with multi-drug resistant (MDR) gram-negative bacilli are associated with significant morbidity and mortality after solid organ transplant. This study characterized patient outcomes related…
  • 2018 American Transplant Congress

    Long Term Culture of Functional Bone Marrow-Derived Human Plasma Cells

    N. Moore, K. Bonner, M. D'Costa, M. Stegall.

    William J. von Liebig Center for Transplantation and Clinical Regeneration, Mayo Clinic, Rochester, MN.

    Introduction Antibody-secreting plasma cells (PCs) are critically important for host defense, but also can cause antibody-mediated allograft rejection. The ability to study these cells is…
  • 2018 American Transplant Congress

    Dehydropeptidase-Iinhibitor Reduces Tacrolimus-Induced Kidney Injury by Anti-Oxidative and Anti-Apoptotic Effect

    K. Luo,1 S. Lim,1 J. Il,1 Y. Shin,1 E. Ko,1,2 B. Chung,1,2 H. Hwang,1,2 C. Yang.1,2

    1Seoul St. Mary's Hospital, The Catholic University of Korea, Seoul, Republic of Korea; 2Transplant Research Center, The Catholic University of Korea, Seoul, Republic of Korea.

    Background:Cilastatin is an inhibitor of dehydropeptidase-I which enhances the antibacterial activity of imipenem.Dehydropeptidase I is associated with not only the metabolism of the enzyme but…
  • 2018 American Transplant Congress

    Graft CEACAM1 is Essential to Autophagy Induction and T-Cell Regulation in Liver Transplantation: From Mouse-to-Human

    K. Nakamura,1 S. Kageyama,1 M. Kujawski,2 T. Ito,1 A. Aziz,1 D. Oncel,1 B. Ke,1 R. Sossa,3 E. Reed,3 F. Kaldas,1 R. Busuttil,1 J. Kupiec-Weglinski.1

    1Surgery, Liver Transplant, UCLA, Los Angeles, CA; 2Molecular Immunology, City of Hope, Duarte, CA; 3Pathology, UCLA, Los Angeles, CA.

    We have documented crucial role of TIM-3 dependent T cell dysfunction in mouse orthotopic liver transplantation (OLT). CEACAM1 (CM1; Carcinoembryonic Antigen-Related Cell Adhesion Molecule 1),…
  • 2018 American Transplant Congress

    High Dose Tissue Plasminogen Activator Flush during Donation-after-Cardiac-Death (DCD) Liver Procurements Offers Optimal Outcomes

    J. Torabi,2 J. Graham,1,2 S. Bellmare,1,2 M. Kinkhabwala,1,2 J. Rocca.1,2

    1Montefiore Center for Transplantation, Montefiore Medical Center, Bronx, NY; 2Albert Einstein College of Medicine, Bronx, NY.

    BackgroundEfforts to expand the donor pool have resulted in increased utilization of donation-after-cardiac-death (DCD) liver donors. Here we report on our experience using high dose…
  • 2018 American Transplant Congress

    How Safe is Immunosuppression Maintenance 1 Year after Renal Allograft Failure?

    A. Mena-Gutierrez, K. Alquadan, A. Santos, K. Womer, M. Casey.

    University of Florida, Gainesville.

    In 2013, our center opened a specialty clinic to maintain immunosuppression (IS) after renal graft failure in an attempt to minimize further sensitization in retransplant…
  • 2018 American Transplant Congress

    Angiotensin II Type 1 Receptor Antibodies as Markers of Post Transplant Focal Segmental Glomerulosclerosis and Proteinuria

    A. Aala, M. Philogene, N. Alachkar.

    Medicine, The Johns Hopkins University School of Medicine, Baltimore, MD.

    Background:Angiotensin II type 1 receptor (AT1R) is highly expressed on the endothelial cells and podocytes, which play an essential role in the maintenance of vascular…
  • 2018 American Transplant Congress

    The Combination of Area under Curve of Estimated Glomerular Filtration Rate for 2 Years and Annual Rate Change of Estimated Glomerular Filtration Rate Predicts Long-Term Graft Survival in Kidney Transplants

    E. Lee,1 J. Jeon,1 S. Kim,1 M. Kim,1 K. Lee,1 H. Jang,1 J. Lee,1 J. Hwang,2 D. Kim,1 Y-.G. Kim,1 H. Oh,1 W. Huh,1 J. Kim.3

    1Department of Medicine, Samsung Medical Center, Seoul, Republic of Korea; 2Department of Anesthesiology and Pain Medicine, Seoul National University BunDang Hospital, Sungnam, Republic of Korea; 3Department of Surgery, Samsung Medical Center, Seoul, Republic of Korea.

    Improvement of short-term outcomes in kidney transplant (KT) has required clinical trials to evaluate long-term hard outcomes for validation of new therapies. However, because of…
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