Am J Transplant, Volume 18, Suppl 3 Archives - Page 191 of 211 - ATC Abstracts

2018 American Transplant Congress
How Should Pancreas Transplant Rejection Be Treated?
F. Aziz, S. Parajuli, S. Salahuddin, K. Harrold, A. Djamali, B. Astor, J. Odorico, D. Mandelbrot.
Department of Nephrology, University of Wisconsin, Madison.
How Should Pancreas Transplant Rejection be Treated?Background: There is limited information about how to approach the treatment of pancreas rejection, particularly regarding the use of…
2018 American Transplant Congress
Obese Patients Show Resistance to Narcotics Reduction after TPIAT for Chronic Pancreatitis
G. Yoshimatsu,¹ B. Naziruddin,³ K. Kumano,² H. Fernandez,³ E. Beecherl,³ N. Onaca.³
¹Fukuoka University, Fukuoka, Japan; ²Baylor Scott and White Research Institute, Dallas; ³Baylor Simmons Transplant Institute, Dallas.
Total pancreatectomy with islet autotransplantation (TPIAT) is an effective treatment option for chronic pancreatitis patients with refractory pain. Patients with high BMI (>30) are known…
2018 American Transplant Congress
Multidisciplinary Approach to Prevention of Cytomegalovirus (CMV) Complications in Kidney and Liver Transplant Recipients
S. Shoham,¹ S. Anderson,² R. Avery,¹ M. Belden,³ L. Boyer,³ W. Cochran,³ N. Desai,¹ M. Holechek,³ E. Kraus,¹ J. Langlee,³ P. Spitz,² K. Marr.¹
¹Johns Hopkins University School of Medicine, Baltimore, MD; ²IT@JH Epic, JHMI: Johns Hopkins Health System, Baltimore, MD; ³Comprehensive Transplant Center, JHMI: Johns Hopkins Hospital, Baltimore, MD.
Background: CMV infection can be prevented in most SOT recipients providing that a prevention protocol is followed. We discovered that our center's protocol, which includes…
2018 American Transplant Congress
Mitochondrial Membrane Permeability Plays a Critical Role for Endothelial Cell Necroptosis and Cardiac Allograft Rejection
I. Gan, J. Jiang, D. Lian, X. Huang, W. Liu, A. Haig, A. Jevnikar, Z. Zhang.
Matthew Mailing Centre for Translational Transplant Studies, University of Western Ontario, London, ON, Canada; Multi Organ Transplant Program, London Health Sciences Centre, London, ON, Canada; Pathology and Laboratory Medicine, University of Western Ontario, London, ON, Canada; Medicine, University of Western Ontario, London, ON, Canada.
Background: Transplant injury is invariably associated with programmed cell death resulting in delayed graft function and organ rejection. We were the first to describe receptor-interacting…
2018 American Transplant Congress
Acute Murine CMV Infection Results in Loss of Intragraft CD73^HIFR4^HIPD1⁺ CD4 T Cells and Graft Rejection in Previously Tolerant Recipients
A. Dangi,¹ L. Zhang,¹ X. Zhang,² X. Luo.^1,2
¹Division of Nephrology and Hypertension, Department of Medicine, Northwestern University, Chicago, IL; ²Comprehensive Transplant Center, Department of Surgery, Northwestern University, Chicago, IL.
Background: Transplantation tolerance in human recipients has been achieved in recent trials. Nevertheless, the impact of highly prevalent and clinically relevant cytomegalovirus (CMV) infection on…
2018 American Transplant Congress
Organ-Specific Differences in a Thymoglobulin and Belatacept-Based Protocol for Tolerance Induction in Non-Human Primates
W. Sommer, J. O., K. Robinson, A. Dehnadi, M. Hanekamp, I. Rosales, K. Pruner, R. Smith, R. Colvin, T. Kawai, G. Benichou, J. Madsen, J. Allan.
Massachusetts General Hospital, Boston.
In non-human primate lung transplantation, allograft acceptance has been achieved using a delayed mixed-chimerism approach consisting of 4 months of triple-drug immunosuppression followed by donor…
2018 American Transplant Congress
Genome-Wide Association Study Assessing Risk of Rejection in Pediatric Transplant Recipients
T. Papaz,¹ S. Min,¹ O. Lee,¹ T. Blydt-Hansen,³ U. Allen,¹ Y. Avitzur,¹ P. Birk,² B. Foster,⁴ H. Grasemann,¹ L. Hamiwka,⁵ R. Parekh,¹ V. Phan,⁶ S. Urschel,⁷ S. Mital.¹
¹SickKids Hospital, Toronto, ON, Canada; ²Winnipeg Children's Hospital, Winnipeg, MB, Canada; ³BC Children's Hospital, Vancouver, BC, Canada; ⁴Montreal Children's Hospital, Montreal, QC, Canada; ⁵Alberta Children's Hospital, Calgary, AB, Canada; ⁶CHU Sainte Justines, Montreal, QC, Canada; ⁷Stollery Children's Hospital, Edmonton, AB, Canada.
Background: Rejection risk varies after solid organ transplantation (SOT). We explored genomic variants associated with susceptibility to graft rejection.Methods: SOTs enrolled in a multicenter prospective…
2018 American Transplant Congress
Targeting Histone Deacetylase in Renal Tubular Epithelial Cells Inhibits Amplification of TH1 Cell-Mediated Inflammation
S. Kang, Y. Kim, S. Seo.
Inje University, Busan, Korea.
Background: Objective: More studies are focusing on renal tubular epithelial cells (RTECs) as a new target to restore inflammatory environment as clarifying their immune regulatory…
2018 American Transplant Congress
Targeting Lymphotoxin Signaling in Lymphatics Regulates Immune Sensitization, Elicitation, and Resolution
W. Piao, Y. Xiong, L. Li, V. Saxena, J. Bromberg.
UMB, MD.
Background:Contact hypersensitivity (CHS) is a T cell-mediated cutaneous inflammatory response which includes three phases of priming/sensitization, elicitation, and resolution,mirroring many aspects of allogeneic responses. The…
2018 American Transplant Congress
Hemodynamic and Functional Analysis of Human DCD Hearts Undergoing Normothermic Ex Vivo Perfusion
W. Sommer, N. Roy, S. Kilmarx, J. O., J. Titus, M. Villavicencio, J. Stone, J. Madsen, D. D'Alessandro.
Massachusetts General Hospital, Boston.
Heart donation after circulatory death (DCD) is feasible although little is known about the hemodynamic and functional parameters of these marginal donor organs. We conducted…