Am J Transplant, Volume 18, Suppl 3 Archives - Page 191 of 211 - ATC Abstracts

2018 American Transplant Congress
ABO‐incompatible Deceased Donor Liver Transplantation
X. Luo, C. Haugen, A. Thomas, J. Garonzik-Wang, D. Segev.
Johns Hopkins, Baltimore, MD.
ABO-incompatible liver transplantation (ILT) has increased over the past decade despite reports suggesting that adult ILT recipient have worse outcomes than ABO-compatible liver transplant (CLT)…
2018 American Transplant Congress
Primary Oral Vancomycin Prophylaxis Reduces the Incidence of Clostridium difficile Infection among Lung Transplant Recipients
V. Bajrovic, K. Brizendine.
Cleveland Clinic Foundation, Cleveland, OH.
Purpose: To determine the efficacy of primary oral vancomycin prophylaxis in reducing the incidence of Clostridium difficile infection (CDI) in the early post-op period among…
2018 American Transplant Congress
Regulation of NK Cell Cytotoxicity by TEC Expression of Clr Proteins in Kidney Ischemia Reperfusion Injury (IRI)
B. Fuhrmann,^1,5 D. Lian,⁵ Z. Yin,⁵ S. Ma,^4,5 J. Arp,⁵ Z. Zhang,^2,3,4,5 A. Jevnikar.^1,3,4,5
¹Microbiology and Immunology, Western University, London, Canada; ²Pathology, Western University, London, Canada; ³Medicine, Western University, London, Canada; ⁴Multi-Organ Transplant Program, London Health Sciences Centre, London, Canada; ⁵Matthew Mailing Centre for Translational Transplant Studies, London Health Sciences Centre, London, Canada.
Background: Kidney tubular epithelial cells (TEC) may negatively regulate NK cell activation and cytotoxic capacity by surface expression of a novel class of C-type lectin-related…
2018 American Transplant Congress
Factors Impacting Return to Employment after Liver Transplantation
M. Hassan, M. Abouljoud, N. Sadik, A. Mazur, A. Elbanna, A. Yoshida, M. Jesse.
Henry Ford Health System, Detroit.
Liver transplantation (LT) prolongs the lives of patients with end-stage liver disease (ESLD). Post-LT, 22-55% of patients return to some form of active employment. Age…
2018 American Transplant Congress
Mitigating Risk: Post-Exposure Prophylaxis in Liver Transplant Recipients from Donors with Potential Infectious Exposure
A. Nolan, D. Yarosh, S. Shaikh.
Department of Pharmacy, Medstar Georgetown University Hospital, Washington, DC.
Purpose: Increased risk organ donors are being more commonly utilized given organ shortages. However, there is a small risk of transmission of diseases such as…
2018 American Transplant Congress
Impact of Positive Donor Blood Cultures in Liver Transplant Recipients
D. Bley, D. Lo, G. Lyon III, R. Subramanian, S. Todd.
Emory University Hospital, Atlanta, GA.
The purpose of this study was to describe the bacteremia transmission rate of transplanting livers from donors with positive bacterial blood cultures into liver transplant…
2018 American Transplant Congress
Treatment of Multi-Drug Resistant Gram Negative Infections after Solid Organ Transplant
M. Heldman, B. Nelson, T. Babu, M. Ison.
Comprehensive Transplant Center, Northwestern University, Chicago, IL.
Introduction: Infections with multi-drug resistant (MDR) gram-negative bacilli are associated with significant morbidity and mortality after solid organ transplant. This study characterized patient outcomes related…
2018 American Transplant Congress
Long Term Culture of Functional Bone Marrow-Derived Human Plasma Cells
N. Moore, K. Bonner, M. D'Costa, M. Stegall.
William J. von Liebig Center for Transplantation and Clinical Regeneration, Mayo Clinic, Rochester, MN.
Introduction Antibody-secreting plasma cells (PCs) are critically important for host defense, but also can cause antibody-mediated allograft rejection. The ability to study these cells is…
2018 American Transplant Congress
Dehydropeptidase-Iinhibitor Reduces Tacrolimus-Induced Kidney Injury by Anti-Oxidative and Anti-Apoptotic Effect
K. Luo,¹ S. Lim,¹ J. Il,¹ Y. Shin,¹ E. Ko,^1,2 B. Chung,^1,2 H. Hwang,^1,2 C. Yang.^1,2
¹Seoul St. Mary's Hospital, The Catholic University of Korea, Seoul, Republic of Korea; ²Transplant Research Center, The Catholic University of Korea, Seoul, Republic of Korea.
Background:Cilastatin is an inhibitor of dehydropeptidase-I which enhances the antibacterial activity of imipenem.Dehydropeptidase I is associated with not only the metabolism of the enzyme but…
2018 American Transplant Congress
Graft CEACAM1 is Essential to Autophagy Induction and T-Cell Regulation in Liver Transplantation: From Mouse-to-Human
K. Nakamura,¹ S. Kageyama,¹ M. Kujawski,² T. Ito,¹ A. Aziz,¹ D. Oncel,¹ B. Ke,¹ R. Sossa,³ E. Reed,³ F. Kaldas,¹ R. Busuttil,¹ J. Kupiec-Weglinski.¹
¹Surgery, Liver Transplant, UCLA, Los Angeles, CA; ²Molecular Immunology, City of Hope, Duarte, CA; ³Pathology, UCLA, Los Angeles, CA.
We have documented crucial role of TIM-3 dependent T cell dysfunction in mouse orthotopic liver transplantation (OLT). CEACAM1 (CM1; Carcinoembryonic Antigen-Related Cell Adhesion Molecule 1),…