Am J Transplant, Volume 18, Suppl 3 Archives - Page 190 of 211 - ATC Abstracts

2018 American Transplant Congress
Surgical Categorization Improve Outcomes and Organ Utilization in Liver Transplant
H. Bohorquez,^1,2 H. Sharma,¹ D. Bruce,¹ A. Cohen,^1,2 C. Carmody,^1,2 J. Seal,¹ E. Bugeaud,¹ D. Sonnier,¹ A. Mathur,¹ D. Marroquin,¹ M. Voltz,¹ D. Lucia,¹ G. Loss.^1,2
¹Multi-Organ Transplant Institute, Ochsner Helath System, New Orleans, LA; ²School of Medicine, University of Queensland, New Orleans, LA.
Background: Liver transplant (LT) varies greatly in technical complexity due to factors such as prior surgery, obesity, and portal vein thrombosis (PVT). This must be…
2018 American Transplant Congress
Circulating Exosomes with Lung Self-Antigens, Kα1Tubulin and Collagen V, and Immunoregulatory Molecules Are Present in Bronchiolitis Obliterans Syndrome Following Pediatric Lung Transplantation
M. Sharma,¹ L. Danziger-Isakov,² P. Heeger,³ S. Sweet,⁴ T. Mohanakumar.¹
¹Norton Thoracic Insitute, St. Joseph's Hosp & Med Ctr, Phoenix; ²Cincinnati Children's Hosp Med Ctr, Cincinnati; ³Icahn Sch Med at Mt Sinai, New York; ⁴Washington Univ Sch Med, St. Louis.
Exosomes containing mismatched donor HLA and lung restricted self-antigens (SAgs), Kα1 Tubulin (Kα1T) and Collagen V (Col-V), have demonstrated in sera and bronchoalveolar lavage fluid…
2018 American Transplant Congress
Efficacy of Bronchoscopically-Administered Surfactant in the Setting of Primary Graft Dysfunction after Lung Transplantation
S. Ahmed,¹ M. Soto-Arenall,¹ D. Jackson,¹ D. Erasmus.²
¹Department of Pharmacy, Mayo Clinic in Florida, Jacksonville, FL; ²Department of Transplantation, Mayo Clinic in Florida, Jacksonville, FL.
Primary graft dysfunction (PGD) is a severe form of ischemia and reperfusion acute lung injury presenting within the first 72 hours post-lung transplant. PGD is…
2018 American Transplant Congress
Activation Requirements of Costimulation Blockade-Resistant CD4 T Cells
J. Espinosa, B. Adams, J. Kearns, F. Shaw, R. Osborne, T. Woody, M. Ellis, J. Cheeseman, A. Kirk.
Duke University, Durham.
T cells lose costimulation dependence following primary activation and many phenotypes of terminally differentiated cells have been identified as contributing to costimulation blockade (CoB)-resistant rejection…
2018 American Transplant Congress
Immunomonitoring of Operational Tolerance in Intestinal Transplantation
O. Aguirre, B. Houlihan, T. Fishbein, A. Kroemer.
Medstar Georgetown Transplant Institute, Medstar Georgetown University Hospital, Washington, DC.
A. The purpose of this study is to immunocharacterize the first reported case of intestinal transplant (ITx) operational tolerance, in parallel with a stable ITx…
2018 American Transplant Congress
The Clinical Efficacy of Seasonal Influenza Vaccination – Characteristics of Two Outbreaks of Influenza A(H1N1) in Immunocompromised Patients
I. Helanterä,¹ R. Janes,² V-.J. Anttila.³
¹Transplantation and Liver Surgery, Helsinki University Hospital, Helsinki, Finland; ²Department of Oncology, Helsinki University Hospital, Helsinki, Finland; ³Department of Infectious Diseases, Helsinki University Hospital, Helsinki, Finland.
A. Background. Influenza A(H1N1) causes serious complications in immunocompromised patients. The efficacy of seasonal influenza vaccination in transplant recipients and patients receiving chemotherapy has been…
2018 American Transplant Congress
Clostridium difficile Recurrence in Abdominal Organ Transplant Recipients: Metronidazole versus Oral Vancomycin
A. Moorman,¹ S. Todd,¹ G. Lyon III,² H. Triemer.¹
¹Department of Pharmaceutical Services, Emory University Hospital, Atlanta, GA; ²Division of Infectious Diseases, Emory University, Atlanta, GA.
Clostridium difficile infection (CDI) is one of the most common hospital-acquired infections among the general inpatient population with recurrence rates of 20-30% despite appropriate treatment.…
2018 American Transplant Congress
TACI Polymorphisms Associated with Allograft Rejection in Mice and in Man
M. Barbosa,¹ E. Farkash,² J. Platt,³ M. Cascalho.³
¹Surgery, University of Michigan, Ann Arbor, MI; ²Pathology, University of Michigan, Ann Arbor, MI; ³Surgery/Microbiology and Immunology, University of Michigan, Ann Arbor, MI.
Trans-membrane Activator and CAML Interactor (TACI) controls B cell differentiation and memory and exists as numerous allelic variants in healthy individuals. In fact, TACI is…
2018 American Transplant Congress
UPMC Living Donor Champion Program
C. Caruso, C. Zell, G. Swaytha, B. Angela, S. Sarah, L. Elaine, P. Susan, W. Travis, H. Abhinav.
Transplant Services, University of Pittsburgh Medical Center, Pittsburgh, PA.
Aims: Living donation is a good option to address organ shortage and waitlist mortality, but finding a living donor can be a challenge. The goal…
2018 American Transplant Congress
Persistence and Homing of Autologous Donor-Reactive Ex-Vivo Expanded Regulatory T Cells to Heart Allografts in Lymphodepleted Recipient Monkeys
M. Ezzelarab, Z. Hong, A. Zahorchak, L. Lien, T. Nakao, H. Dai, D. van der Windt, A. Perez-Gutierrez, J. Bhama, A. Thomson.
Surgery, Starzl Transplantation Institute, Pittsburgh, PA.
Background:Infusion of ex vivo expanded regulatory T cells (Treg) is a promising therapy to prevent allograft rejection. Trafficking of Treg to allografts and secondary (2ry)…