ATC Abstracts

American Transplant Congress abstracts

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  • 2018 American Transplant Congress

    Reliability of Bronchiolitis Obliterans Syndrome Reporting to the OPTN

    R. Carrico,1 R. Lehman,1 K. Uccellini,1 K. Chan,2 T. Whelan.3

    1United Network for Organ Sharing, Richmond; 2Univ of Michigan, Ann Arbor; 3Medical Univ of South Carolina, Charleston.

    Background: Chronic rejection of the lung allograft is traditionally classified as bronchiolitis obliterans syndrome (BOS) diagnosed by obstructive airway physiology. The OPTN requires the reporting…
  • 2018 American Transplant Congress

    Evaluation of Survival and Maintenance Immunosuppression in Elderly Lung Transplant Recipients

    P. Nguyen,1 R. Girgis,1,2 E. Murphy,1,2 R. Hadley,1,2 M. Leacche,1,2 A. Kumar,1,2 G. Sathiyamoorthy,1,2 J. McDermott.1,2

    1Spectrum Health, Grand Rapids, MI; 2Michigan State University College of Human Medicine, Grand Rapids, MI.

    Background: Lung transplantation in the elderly is controversial given increased risks and the optimal immunosuppression regimen is not fully understood.Methods: A retrospective cohort study was…
  • 2018 American Transplant Congress

    TLR2 with TCR Signaling Mobilizes Treg Lymphatic Migration

    W. Piao, Y. Xiong, L. Li, V. Saxena, J. Bromberg.

    UMB, MD.

    Background: Regulatory T cells (Treg) express high levels of lymphotoxin (LT) and bind the LT receptor (LTβR) on lymphatic endothelial cells (LEC). This receptor-ligand interaction…
  • 2018 American Transplant Congress

    How the Spouses (Husbands) of Living Kidney Donors View Kidney Donation: A Grounded Theory Study

    J. Kieffer.

    Division of Nursing, University of Mount Olive, Mount Olive, NC.

    The purpose of this study was to explore the question: What is the process of experiencing living kidney transplant by the spouse of a living…
  • 2018 American Transplant Congress

    Efficacy of Two Valganciclovir Dosing Strategies in Intermediate and High-Risk Liver Transplant Recipients

    K. Belfield,1 M. Malinis,2 E. Cohen.1

    1Department of Pharmacy, Yale New Haven Hospital, New Haven, CT; 2Section of Infectious Diseases, Yale School of Medicine, New Haven, CT.

    Purpose: There is interest in reduced dosing and duration of valganciclovir (VGCV) for cytomegalovirus (CMV) prophylaxis in liver transplant (LT) recipients to minimize side effects…
  • 2018 American Transplant Congress

    In Vitro Evaluation of Antibiotic Persistence in Pseudomonas aeruginosa and Staphylococcus aureus Isolates from Cystic Fibrosis Patients

    J. Fose, D. Bruckbauer, M. Jorgenson, W. Rose.

    UW Hospital & Clinics, Madison; UW School of Pharmacy, Madison.

    Purpose: The mechanisms of antibiotic persistence in immunosuppressed populations are not fully understood. Patients with cystic fibrosis (CF), both the pre-transplant and post-transplant phase often…
  • 2018 American Transplant Congress

    Multi-Targeting Desensitization Therapy Alters Peripheral B-Cell Homeostasis and Suppresses Recall Alloantibody Responses

    I. Kim, G. Wu, N-.N. Chai, A. Klein, S. Jordan.

    CTC/Surgery, Cedars-Sinai Medical Center, Los Angeles, CA.

    Purpose: Occurring of donor specific antibodies (DSA) is injurious to organ transplant. Development of immunotherapies to suppress DSA, therefore, has been one of the strategic…
  • 2018 American Transplant Congress

    Pharmacologic Donor Management Influences Liver Transplant Graft Survival and Transplant Admission Length of Stay: An Update

    J. Brandenberger,1 J. Perkins,2 A. Cantafio,3 A. Dick,2 J. Halldorson,4 J. Reyes.2

    1General Surgery; Urology and Renal Transplantation, Virginia Mason Medical Center, Seattle, WA; 2Division of Transplant Surgery, University of Washington, Seattle, WA; 3Division of Transplant Surgery, University of Tennessee Medical Center, Knoxville, TN; 4Division of Transplant Surgery, UCSD, San Diego, CA.

    In liver transplantation, donor management is an area that can be modified to improve survival and lower cost. We reviewed the UNOS Standard Transplant Analysis…
  • 2018 American Transplant Congress

    Characterization of Mesenchymal Stem Cell Phenotype and Its Immunomodulatory Effects during Allo-Specific T Cell Immune-Responses

    Q. Gao, A. Kirk, H. Xu.

    Department of Surgery, Duke University Medical Center, Durham, NC.

    Mesenchymal stem cells (MSCs) have been suggested play an important role in modulating cell-mediated immunity. In the setting of transplantation, allogeneic MSCs could mediate suppressive…
  • 2018 American Transplant Congress

    The Impact of Pre-Operative Opioid Use on Delayed Graft Function in Adult Kidney Transplant Recipients

    N. Patel, B. O'Brien, D. Taber, N. Pilch, P. Baliga, Z. Elmaasarani, S. Ball, P. Mauldin, L. Wilson, R. Gilbert, J. Fleming.

    MUSC, Charleston, SC.

    Background and Objectives: Opioid use is associated with AKI and ATN through both direct and indirect mechanisms, including alterations in the autonomic nervous system, the…
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