ATC Abstracts

American Transplant Congress abstracts

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  • 2018 American Transplant Congress

    Predicting Survival after Deceased-Donor Kidney Transplants by Donor-Recipient Match: Who Can Tolerate a High-KDPI Kidney?

    S. Bae, J. Garonzik Wang, K. Jackson, A. Thomas, X. Luo, A. Massie, D. Segev.

    Johns Hopkins School of Medicine, Baltimore, MD.

    Deceased-donor kidney transplantation (DDKT) with high-KDPI kidneys carries an additional risk of mortality and graft failure, which could be tolerable for some candidates but detrimental…
  • 2018 American Transplant Congress

    Transplantation of Kidneys from Hepatitis C Virus (HCV) Antibody (Ab) Positive, NAT Negative Donors to HCV Negative Patients Results in Seroconversion but Not Viral Transmission

    M. de Vera, M. Volk, Z. Ncube, A. Kore, M. Robinson, P. Wai, S. Blais, P. Baron, R. Villicana.

    Transplant Surgery, Loma Linda University Health, Loma Linda, CA.

    Anecdotal reports have suggested that transplantation of HCV Ab+/NAT- donor kidneys into HCV negative recipients is safe and not associated with HCV transmission. With the…
  • 2018 American Transplant Congress

    Endothelin-1 Type A Receptor Antibodies Are Associated with Elevated Il-8, Arteritis and Decline in Renal Function in Pediatric Renal Transplant Recipients

    M. Pearl,1 J. Grotts,1 M. Rossetti,1 Q. Zhang,1 P. Weng,1 E. Reed,1 E. Tsai Chambers.2

    1University of California, Los Angeles, Los Angeles, CA; 2Duke University, Durham, NC.

    Background: We have recently shown that the non-HLA antibody, AT1R-Ab, is prevalent and associated with poor outcomes in pediatric kidney transplant recipients (KTRs). The prevalence…
  • 2018 American Transplant Congress

    Impact of Changes to the LAS Calculation

    R. Lehman,1 R. Carrico,1 K. Uccellini,1 K. Chan,2 T. Whelan.3

    1United Network for Organ Sharing, Richmond, VA; 2Univ of Michigan, Ann Arbor, MI; 3Medical Univ of South Carolina, Charleston, SC.

    Purpose: On 2/19/2015 major revisions to the Lung Allocation Score (LAS) calculation were made to more appropriately reflect candidates' waiting list urgency and post-transplant survival.…
  • 2018 American Transplant Congress

    Human Thrombomodulin Expression on Genetically Modified Donor Pigs is Required to Maintain the Anti-Coagulation Profile

    A. Singh, L. DiChiacchio, J. Chan, P. Corcoran, B. Lewis, M. Thomas, D. Ayares, K. Horvath, M. Mohiuddin.

    CSRP/NHLBI and DVR/ORS, NIH, Bethesda, MD; Revivicor Inc., Blacksburg, VA; Dept of Surgery, University of Maryland, Baltimore, MD.

    Introduction: Coagulation dysregulation is major limitation for xenotransplantation but it is resolved to some extent by making genetically engineered (GE) pigs, which express complement inhibitors…
  • 2018 American Transplant Congress

    Treatment Outcomes of Recurrent Primary Focal Segmental Glomerulosclerosis (FSGS) after Kidney Transplantation

    R. Aguiar,1 F. Pereira,2 A. Gasparini,3 P. Chowdhury,1 D. Game,1 D. Moutzouris.1

    1Department of Nephrology and Transplantation, Guy's and St. Thomas' NHS Foundation Trust, London, United Kingdom; 2Department of Renal Medicine, Hospital Dr. Fernando Fonseca, Lisbon, Portugal; 3Department of Health Sciences, University of Leicester, Leicester, United Kingdom.

    Introduction: Primary FSGS can recur in the renal allograft and is associated with poor graft outcomes. There is no established therapeutic intervention to prevent or…
  • 2018 American Transplant Congress

    Precision Medicine for Determining the Efficacy of a Novel Belatacept Regimen

    J. Shoji, J. Leung, E. Tavares, Q. Tang, F. Vincenti.

    Transplant Nephrology, UCSF, San Francisco, CA.

    IntroBelatacept is increasingly used as maintenance immunosuppression to improve long term outcomes in kidney transplant. Since acute rejection in patients on belatacept have been noted…
  • 2018 American Transplant Congress

    Use of Proton-Pump Inhibitors is Associated with Lower Magnesium and Iron Status and Excess Mortality in Renal Transplant Recipients

    A. Gomes-Neto,1 R. Douwes,1 M. Eisenga,1 S. Berger,1 R. Gans,1 E. Berg,1 G. Navis,1 H. Blokzijl,2 S. Bakker.1

    1Nephrology, UMCG, Groningen, Netherlands; 2Gastroenterology and Hepatology, UMCG, Groningen, Netherlands.

    BackgroundProton-pump inhibitor (PPI) use is common in renal transplant recipients (RTR). However, PPI use may induce micronutrient deficiencies and has been associated with increased mortality…
  • 2018 American Transplant Congress

    Worsening Racial/Ethnic Disparities in Pediatric Kidney Transplant Outcomes in the US

    T. Purnell, X. Luo, L. Cooper, D. Crews, K. Covarrubias, A. Massie, D. Segev.

    Johns Hopkins, Baltimore.

    Purpose: We recently demonstrated narrowed racial/ethnic disparities in adult kidney transplant (KT) outcomes in the US. The goal of this study was to examine twenty-year…
  • 2018 American Transplant Congress

    Elevated Serum Penteraxin in Cardiac Allograft Antibody Mediated Rejection: From Cytokine Arrays to Patients with ABMR

    O. Moussa,3 M. Kavarana,2 L. Klingman,1 J. Felius,1 S. Hall,1 M. Askar.1

    1Baylor Research Institute, Dallas; 2Medical University of South Carolina, Charleston; 3University of Michigan, Ann Arbor, MI.

    Pentraxin 3 (PTX3) is soluble protein that has been implicated in in atherosclerosis, endothelial function, hypertension, myocardial infarction and angiogenesis (Fornai et al., 2016). We…
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