2018 American Transplant Congress
Predicting Survival after Deceased-Donor Kidney Transplants by Donor-Recipient Match: Who Can Tolerate a High-KDPI Kidney?
Johns Hopkins School of Medicine, Baltimore, MD.
Deceased-donor kidney transplantation (DDKT) with high-KDPI kidneys carries an additional risk of mortality and graft failure, which could be tolerable for some candidates but detrimental…2018 American Transplant Congress
Transplantation of Kidneys from Hepatitis C Virus (HCV) Antibody (Ab) Positive, NAT Negative Donors to HCV Negative Patients Results in Seroconversion but Not Viral Transmission
Transplant Surgery, Loma Linda University Health, Loma Linda, CA.
Anecdotal reports have suggested that transplantation of HCV Ab+/NAT- donor kidneys into HCV negative recipients is safe and not associated with HCV transmission. With the…2018 American Transplant Congress
Endothelin-1 Type A Receptor Antibodies Are Associated with Elevated Il-8, Arteritis and Decline in Renal Function in Pediatric Renal Transplant Recipients
1University of California, Los Angeles, Los Angeles, CA; 2Duke University, Durham, NC.
Background: We have recently shown that the non-HLA antibody, AT1R-Ab, is prevalent and associated with poor outcomes in pediatric kidney transplant recipients (KTRs). The prevalence…2018 American Transplant Congress
Impact of Changes to the LAS Calculation
Purpose: On 2/19/2015 major revisions to the Lung Allocation Score (LAS) calculation were made to more appropriately reflect candidates' waiting list urgency and post-transplant survival.…2018 American Transplant Congress
Human Thrombomodulin Expression on Genetically Modified Donor Pigs is Required to Maintain the Anti-Coagulation Profile
Introduction: Coagulation dysregulation is major limitation for xenotransplantation but it is resolved to some extent by making genetically engineered (GE) pigs, which express complement inhibitors…2018 American Transplant Congress
Treatment Outcomes of Recurrent Primary Focal Segmental Glomerulosclerosis (FSGS) after Kidney Transplantation
Introduction: Primary FSGS can recur in the renal allograft and is associated with poor graft outcomes. There is no established therapeutic intervention to prevent or…2018 American Transplant Congress
Precision Medicine for Determining the Efficacy of a Novel Belatacept Regimen
Transplant Nephrology, UCSF, San Francisco, CA.
IntroBelatacept is increasingly used as maintenance immunosuppression to improve long term outcomes in kidney transplant. Since acute rejection in patients on belatacept have been noted…2018 American Transplant Congress
Use of Proton-Pump Inhibitors is Associated with Lower Magnesium and Iron Status and Excess Mortality in Renal Transplant Recipients
BackgroundProton-pump inhibitor (PPI) use is common in renal transplant recipients (RTR). However, PPI use may induce micronutrient deficiencies and has been associated with increased mortality…2018 American Transplant Congress
Worsening Racial/Ethnic Disparities in Pediatric Kidney Transplant Outcomes in the US
Purpose: We recently demonstrated narrowed racial/ethnic disparities in adult kidney transplant (KT) outcomes in the US. The goal of this study was to examine twenty-year…2018 American Transplant Congress
Elevated Serum Penteraxin in Cardiac Allograft Antibody Mediated Rejection: From Cytokine Arrays to Patients with ABMR
Pentraxin 3 (PTX3) is soluble protein that has been implicated in in atherosclerosis, endothelial function, hypertension, myocardial infarction and angiogenesis (Fornai et al., 2016). We…
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