Am J Transplant, Volume 18, Suppl 3 Archives - Page 187 of 211 - ATC Abstracts

2018 American Transplant Congress
Factor Analysis (FA) Identifies 5 Major Axes of Kidney Transplant Biopsy (KTxBx) Pathology
L. Hunsicker,¹ J. Grande,² J. Cecka,³ A. Matas,⁴ The DeKaf Consortium.
¹Int. Med., U. Iowa, Iowa City, IA; ²Pathology, Mayo Clinic, Rochester, MN; ³Immunogenetics, UCLA, Los Angeles, CA; ⁴Surgery, U. Minnesota, Minneapolis, MN.
Definitions for acute rejection (ACR) and antibody mediated rejection (AMR) in KTxBx exist, but no data driven methods exist for quantitative analysis of all Banff,…
2018 American Transplant Congress
Preformed Donor-Reactive T-Cells That Persist after ABO Desensitization Independently Predict Severe Acute Cellular Rejection after Living Donor Kidney Transplantation
T. Schachtner,^1,2,3 M. Stein,² P. Reinke.^1,2
¹Nephrology and Internal Intensive Care, Charite Campus Virchow Clinic, Berlin, Germany; ²Berlin-Brandenburg Center for Regenerative Therapie (BCRT), Charite Campus Virchow Clinic, Berlin, Germany; ³Berlin Institute of Health (BIH), Charite and Max Delbrueck Center, Berlin, Germany.
Donor-reactive T-cells have been suggested to impact allograft outcome due to a higher incidence of acute celluar rejection. These donor-reactive memory T-cells rapidly acquire effector…
2018 American Transplant Congress
Robotic Assisted Live Donor Kidney Transplantation – Technique and Outcomes
H. Pahari,¹ B. Waldman,² J. Stracke,¹ L. Malinzak,¹ J. Denny,¹ D. Kim,¹ W. Jeong,³ M. Menon,³ A. Yoshida.¹
¹Transplant Surgery, Henry Ford Hospital, Detroit, MI; ²Wayne State University, Detroit, MI; ³Urology, Henry Ford Hospital, Detroit, MI.
Background: Robotic assisted kidney transplantation (RAKT) is now a feasible minimally invasive option in place of open living donor kidney transplant (OKT). Here, we briefly…
2018 American Transplant Congress
Frequency of Whole-Organ in Lieu of Split-Liver Transplantation over the Last Decade: Children Experienced Increased Wait Time and Death
P. Valentino,¹ S. Emre,² L. Li,³ Y. Deng,³ G. Gan,³ D. Mulligan,² U. Ekong,¹ M. Rodriguez-Davalos.⁴
¹Pediatrics, Hepatology, Yale University, New Haven, CT; ²Surgery, Transplant, Yale University, New Haven, CT; ³Yale Center for Analytical Sciences, Yale University, New Haven, CT; ⁴Surgery, Transplant, Primary Children's Hospital, Salt Lake City, UT.
Background: Organ shortage is a barrier in liver transplantation (LT). Split liver transplantation (SLT) increases organ utilization where a donor provides segmental grafts to 2…
2018 American Transplant Congress
Pancreas Transplant in the Elderly Patient – Should It Be Done?
A. Gruessner,¹ M. Laftavi,² O. Pankewycz,² R. Gruessner.¹
¹SUNY Downstate Medical Center, Brooklyn, NY; ²SUNY Upstate Medical University, Syracuse, NY.
Introduction: While kidney transplantation in the elderly diabetic patient is an accepted treatment of the secondary complication, pancreas transplants are controversial. Many centers have an…
2018 American Transplant Congress
Ablation of IRF4 Induces Transplant Tolerance by Driving Intrinsic T Cell Dysfunction
J. Wu,^1,2 H. Zhang,¹ X. Shi,¹ X. Xiao,¹ Y. Fan,¹ J. Xia,² R. Sciammas,^1,3 X. Li,^1,3 W. Chen.^1,3
¹Center for Immunobiology & Transplant Science, Houston Methodist Research Institute, Houston, TX; ²Department of Cardiovascular Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China; ³Department of Surgery, Weill Cornell Medical College of Cornell University, New York, NY.
How transplant rejection is regulated on a transcriptional level remains unclear. We found that T cell-specific conditional knockout (cKO) of the transcription factor IRF4 in…
2018 American Transplant Congress
Pro-Inflammatory B Cells Predict Progressive Minimal Early Renal Allograft Inflammation Which is Associated with Poor Graft Outcomes
A. Sharma, A. Cherukuri, D. Chittka, R. Mehta, S. Hariharan, D. Rothstein.
UPMC, Pittsburgh.
The clinical significance of minimal tubulointerstitial inflammation (MTI:'t'+'i'scores 0.5-1.5) and Banff Borderline changes (BBC:'t'+'i'scores 2-3) in early renal allograft biopsies is unclear. The rate and…
2018 American Transplant Congress
Parsing the 100% CPRA Kidney Transplant Candidates, Who Gets Transplanted?
D. Keith.
Medicine, Sacred Heart Hospital, Pensacola, FL.
Currently the United States kidney allocation system gives priority to candidates with a CPRA of 100% by giving them additional allocation points and providing national…
2018 American Transplant Congress
Cell Free DNA Sequencing for Diagnosing Infections, Estimating Growth Rates, and Characterizing Antibiotic Resistomes in Urine Supernatants
J. Lee,¹ P. Burnham,² D. Dadhania,¹ M. Heyang,² F. Chen,² M. Suthanthiran,¹ I. De Vlaminck.²
¹Weill Cornell Medicine, New York, NY; ²Cornell University, Ithaca, NY.
INTRODUCTION. We examined the utility of cell-free DNA (cfDNA) sequencing of urine supernatants in kidney transplant recipients for diagnosing rare and common urinary tract infections…
2018 American Transplant Congress
Early Microcirculation Inflammation Associated with TCMR Leads to Poor Graft Outcomes in Kidney Transplant Recipients (KTRs)
A. Cherukuri, D. Chittka, R. Mehta, A. Sharma, P. Sood, S. Hariharan.
UPMC, Pittsburgh.
Renal allograft microcirculation inflammation (MI) lesions including glomerulitis (g) and peritubular capillaritis (ptc) are associated with AMR and poor outcomes. The significance of MI lesions…