Am J Transplant, Volume 18, Suppl 3 Archives - Page 183 of 211 - ATC Abstracts

2018 American Transplant Congress
Transplant Community Perceptions of the Benefits and Drawbacks of Alternative Quality Metrics for Regulation
S. Rasmussen, S. Zhou, A. Thomas, D. Segev, L. Hersch Nicholas.
JHU, Baltimore.
Background: Quality metrics are used to regulate transplant centers, inform patients, and improve quality of care. Currently graft and patient survival are used to regulate…
2018 American Transplant Congress
Development of Post-Transplant DSA Following Immunosuppression Minimization/Withdrawal in Liver Transplant Recipients
V. Jucaud,¹ A. Shaked,² M. DesMarais,³ P. Sayre,³ M. Everly.¹
¹Terasaki Research Institute, Los Angeles; ²University of Pennsylvania, Philadelphia, PA; ³Immune Tolerance Network, Seattle, WA.
Despite the allograft-risk associated with DSA, the development of post-transplant HLA donor-specific antibody (DSA) is not well described in liver transplant (LT) patients undergoing immunosuppression…
2018 American Transplant Congress
Tax1bp3 is Upregulated in the Ischemia/Reperfusion Injury of Kidney
W. Qiu, J. Lin, Y. Tian.
Department of Urology, Beijing Friendship Hospital, Capital Medical University, Beijing, China.
Objective The ischemia/reperfusion (I/R) injury plays an important role in delayed graft function (DGF) after kidney transplantation, however, the mechanism is not fully understood. Therefore,…
2018 American Transplant Congress
Association of Leptin with Cystatin C in Kidney Allograft Dysfunction
A. Bera,¹ M. Watson,² N. Gana,¹ J. Karaian,¹ S. Radhakrishnan,¹ M. Subramanian,¹ D. Little,² R. Nee,² A. Chatterjee,¹ S. Rothwell,¹ H. Pollard,¹ R. Jindal,³ M. Srivastava.¹
¹Anatomy, Physiology and Genetics, USU-School of Medicine, Bethesda, MD; ²Nephrology, USU-Walter Reed, Bethesda, MD; ³Surgery, USU-Walter Reed, Bethesda, MD.
Background: Non-invasive biomarkers are needed for monitoring recipients of kidney allografts to predict acute rejection (AR). We hypothesized that protein biomarkers released from rejecting allograft…
2018 American Transplant Congress
Time and Perfusate Dependent Molecular Response in Ex Vivo Lung Perfusion
P. Dromparis,¹ N. Aboelnazar,² S. Wagner,¹ S. Himmat,² C. White,² J. Luc,² D. Freed,² J. Nagendran,² M. Mengel,¹ B. Adam.¹
¹Department of Laboratory Medicine and Pathology, University of Alberta, Edmonton, Canada; ²Department of Surgery (Cardiac), University of Alberta, Edmonton, Canada.
Lung transplantation has limited organ utilization and high rates of primary graft dysfunction, in part due to acute lung injury (ALI). Cold static preservation (CSP)…
2018 American Transplant Congress
A Novel Preservation Solution for Lung That Improves Cell Viability and Tissue Architecture
J. Friedman,¹ M. Samamrco,¹ L. Marrero,¹ B. Bunnell,¹ D. Spyropoulos.²
¹Tulane University, New Orleans; ²MUSC, Charleston.
Backgroud: Only 20% of donor lungs are used for transplant and 10 y survival of recipients is low. Many patients die within 30 d of…
2018 American Transplant Congress
Gr1^– Macrophages Play Critical Roles in Liver Inflammation Resolution after IRI via Efferocytosis
M. Ni,^1,2 H. Wang,^1,2 R. Busuttil,¹ J. Kupiec-Weglinski,¹ X. Wang,² Y. Zhai.¹
¹Surgery, David Geffen School of Medicine-UCLA, Los Angeles, CA; ²Liver Surgery, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiansu, China.
Inflammation resolution is an integral part of liver ischemia reperfusion injury (IRI), which affects not only the severity of tissue damage, but more importantly its…
2018 American Transplant Congress
Histone Deacetylase-6 Inhibition Mitigates Liver Ischemia-Reperfusion Injury and Acetaminophen Toxicity in Mice
S. Concors,¹ D. Murken,¹ D. Aufhauser,¹ Z. Wang,¹ G. Ge,¹ T. Bhatti,⁴ W. Hancock,^3,4 M. Levine.^1,2
¹Surgery, University of Pennsylvania, Philadelphia, PA; ²Surgery, Children's Hospital of Philadelphia, Philadelphia, PA; ³Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA; ⁴Pathology and Laboratory Medicine, Children's Hospital of Philadelphia, Philadelphia, PA.
Introduction: Ischemia/reperfusion injury (IRI) leads to poor outcomes and early graft loss in liver transplantation. Understanding the mechanisms of liver IRI may aid in prevention…
2018 American Transplant Congress
CD19+ Cell Ratio as a Predictive Marker of Antibody Mediated Rejection in ABO Incompatible Kidney Transplantation
K. Unagami,¹ R. Maenosono,² M. Furusawa,² Y. Kakuta,² M. Okumi,² H. Ishida,² K. Tanabe,² K. Nitta.¹
¹Nephrology, Tokyo Women's Medical University, Tokyo, Japan; ²Urology, Tokyo Women's Medical University, Tokyo, Japan.
Background: Rituximab has been suggested to deplete B cells and decrease the possibility of antibody mediated rejection (AMR) in ABO-incompatible living kidney transplantation (ABO-ILKT). We…
2018 American Transplant Congress
The Impact of Pre-Transplant Donor Specific Antibodies (DSA) on AMR Rates in HIV-Infected Kidney Transplant Recipients Inducted with IL-2 RA
S. Farouk, B. Rollins, V. Delaney, N. Singh, V. Sehgal, R. Kent, M. Menon, R. Shapiro, S. Florman, G. DeBoccardo.
Recanati Miller Transplant Institute, Icahn School of Medicine at Mt. Sinai, New York, NY.
Background: 1-year rejection rates in HIV-infected kidney transplant recipients range from 15-40%, compared to overall rejection rates of 10% in HIV-negative patients. We report the…