ATC Abstracts

American Transplant Congress abstracts

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  • 2018 American Transplant Congress

    APRIL/BLyS Blockade Improves Depletion of Antibody Secreting B Cells Compared to BLyS Blockade Alone in Sensitized Murine Kidney Transplant Model

    N. Bath,1 X. Ding,1 N. Wilson,2 B. Verhoven,1 A. Sukhwal,1 L. Coons,1 S. Panzer,2 A. Djamali,2 R. Redfield.1

    1Surgery, University of Wisconsin, Madison, WI; 2Medicine, University of Wisconsin, Madison, WI.

    Introduction: Antibody mediated rejection (AMR) remains a significant problem in highly sensitized individuals undergoing kidney transplantation. APRIL (A Proliferation Inducing Ligand) and BLyS (B Lymphocyte…
  • 2018 American Transplant Congress

    QPI-1002, a siRNA Targeting p53: Improvement in Outcomes Following Acute Kidney Injury (AKI): Cardiac Surgery to AKI Donors

    J. Tchervenkov,2 E. Squiers,1 R. Stratta,3 D. Odenheimer,2 D. Rothenstein,2 QPI-1002 DGF Study Group.

    1Quark Pharmaceuticals, Fremont; 2McGill University Health, Montreal, Canada; 3Wake Forest School of Medicine Centre, Winston-Salem.

    Background: QPI-1002 has been observed to statistically reduce the incidence, severity and duration of AKI in a large Phase 2 study of AKI following cardiac…
  • 2018 American Transplant Congress

    Effect of Induction Therapy on CD4 Cell Count Recovery Following Renal Transplantation in HIV Positive Recipients – A Single Center Experience

    J. Chique Figueroa, M. Prendergast, H. Wadei, M. Mai, K. Oshel, D. Leonard.

    Department of Transplantation, Mayo Clinic College of Medicine, Jacksonville, FL.

    The feasibility, complications and outcomes of solid organ transplantation in the HIV positive population are well documented and have had excellent outcomes with a slight…
  • 2018 American Transplant Congress

    Efficacy of At-Home Transplant Education on Transplant Knowledge and Pursuit in Low-Income and Black Dialysis Patients with Varying Educational Characteristics

    A. Waterman,1,2 J. Peipert,1,2 J. Beaumont.2

    1Division of Nephrology, David Geffen School of Medicine at UCLA, Los Angeles, CA; 2Terasaki Research Institute, Los Angeles, CA.

    The Explore Transplant @ Home (ETH) randomized controlled trial assessed the efficacy of two supplementary education strategies for kidney transplant (KT) in dialysis centers: 1)…
  • 2018 American Transplant Congress

    Diagnostic Accuracy of Non-Invasive Test of Hepatic Fibrosis in Liver Transplant Recipients

    D. Galvez,1 C. Bhati,1 M. Siddiqui,2 C. Schmoyer,2 T. Arshad,2 A. Sharma,1 A. Cotterell,1 K. Yadav,1 T. Reichman,1 M. Levy.1

    1Department of Surgery, Virginia Commonwealth University Hospital, Richmond, VA; 2Department of Medicine, Virginia Commonwealth University Hospital, Richmond, VA.

    Background & Aims: Hepatic fibrosis is an important predictor of liver- and non-liver related outcomes in patients with chronic liver disease (CLD) and liver transplantation…
  • 2018 American Transplant Congress

    Identification of Human SIRPa Diversity That Could Regulate Innate Allorecognition

    A. Friday,1 H. Dai,1 A. Williams,1 M. Oberbarnscheidt,1 J. Danska,2 F. Lakkis.1

    1Starzl Transplantation Institute, University of Pittsburgh, Pittsburgh, PA; 2Immunology and Medical Biophysics, University of Toronto, Toronto, ON, Canada.

    Innate allorecognition is a process by which myeloid cells, such as monocytes, distinguish syngeneic from allogeneic cells. Monocytes that recognize donor cells as non-self differentiate…
  • 2018 American Transplant Congress

    Evaluating the Impact of Pre-Transplant Malignancy on Outcomes after Kidney Transplantation: A National Database Analysis over a Twenty-Two Year Period

    D. Livingston-Rosanoff, L. Wilke, G. Leverson, D. Foley.

    Dept. of Surgery, University of Wisconsin, Madison, WI.

    Introduction: Patients with a history of malignancy prior to kidney transplantation are known to develop more post-transplant malignancies and have inferior outcomes. However, there have…
  • 2018 American Transplant Congress

    Autophagy Impacts Specificity and Characteristics of Innate Alloimmune Responses in Aging

    T. Heinbokel, K. Minami, Y. Nian, A. Elkhal, S. Tullius.

    Transplant Surgery Research Lab, Brigham and Women's Hospital, Boston, MA.

    Aging and chronic antigen exposure shape the balance of innate and adaptive immunity. We hypothesized that autophagy will impact the homeostasis of innate and adaptive…
  • 2018 American Transplant Congress

    C5aR Regulates Myeloid Derived Suppressor Cells (MDSCs) in Transplantation

    I. Llaudo, J. Ochando, P. Heeger.

    Medicine, Icahn School of Medicine at Mount Sinai, New York, NY.

    Prolonged survival of anti-CD154-(MR1)-treated murine heart transplant recipients is dependent on regulatory T cells (Treg) and MDSC. Based on studies in the tumor literature suggesting…
  • 2018 American Transplant Congress

    Molecular Analysis of Acute Cellular Rejection in Clinical Face Transplants

    T. Win, B. Dyring-Andersen, J. Teague, N. Murakami, A. Chandraker, B. Pomahac, L. Riella, R. Clark.

    Brigham and Women's Hospital, Boston.

    Although monitoring and immunosuppression of vascularized composite allografts (VCA) draw experience from solid organ transplantation, VCAs pose unique challenges. A deeper understanding of mechanisms underlying…
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