ATC Abstracts

American Transplant Congress abstracts

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  • 2018 American Transplant Congress

    IgG De Novo HLA Antibody Subclass Analysis in Patients Undergoing Allograft Nephrectomy after Transplant Failure

    G. Lucisano,1 A. Gueret-Wardle,1 P. Brookes,2 E. Santos-Nunez,2 N. Firmin,2 N. Gunby,2 S. Hassan,1 M. Willicombe,1 D. Taube.1

    1Renal and Transplant Centre, Imperial College Healthcare NHS Trust, London, United Kingdom; 2Histocompatibility and Immunogenetics, Imperial College Healthcare NHS Trust, London, United Kingdom.

    Introduction: different immunising events can stimulate the production of disparate antibody subclass profiles, reflecting a diverse extent of T-cell activation. Transplant nephrectomy (NX) is a…
  • 2018 American Transplant Congress

    Failure to Remove De Novo Donor-Specific HLA Antibodies is Influenced by Antibody Properties and Identifies Kidney Recipients with Late Antibody-Mediated Rejection Destined to Graft Loss

    A. Nocera,1 M. Cioni,1 A. Tagliamacco,2 S. Basso,3 A. Innocente,4 I. Fontana,5 A. Magnasco,1 A. Trivelli,1 A. Gurrado,3 M. Ramondetta,4 S. Boghen,3 L. Catenacci,3 E. Verrina,1 G. Garibotto,2 G. Ghiggeri,1 M. Cardillo,4 F. Ginevri,1 P. Comoli.3

    1Pediatric Nephrology Unit, IRCCS G. Gaslini, Genova, Italy; 2Clinical Nephrology Unit, University of Genova, Genova, Italy; 3Transplant Immunology and Pediatric Hematology/Oncology, IRCCS Policlinico S. Matteo, Pavia, Italy; 4Transplantation Immunology, Ospedale Maggiore Policlinico, Milano, Italy; 5Kidney Transplant Surgery Unit, Ospedale Policlinico San Martino, Genova, Italy.

    Late antibody-mediated rejection (AMR) is the major cause of renal allograft loss. Current research is focusing on identifying a performant risk stratification in order to…
  • 2018 American Transplant Congress

    Flow DSA-XM: Better Crossmatch or Just Different Problems?

    P. Kimball, F. McDougan.

    Surgery, VCUHealth Systems, Richmond, VA.

    Background. Despite the positive impact of flow crossmatching(FCXM) upon alloantibody detection, its inability to distinguish anti-Class I from Class II or non-HLA from HLA-antibodies remain…
  • 2018 American Transplant Congress

    Identification of Novel Genetic Variants Associated with Tacrolimus Metabolism in Kidney Transplant Recipients Using Next Generation Sequencing

    C. Dorr,1,2,3 B. Wu,2 R. Remmel,2 A. Muthusamy,1 D. Schladt,1 J. Abrahante,2 W. Guan,2 R. Mannon,4 A. Matas,2 W. Oetting,2 P. Jacobson,2 A. Israni.1,2,3

    1Minneapolis Medical Research Foundation, Minneapolis; 2Univ. of MN, Minneapolis; 3Hennepin County Medical Center, Minneapolis; 4Univ. of AL, Birmingham.

    Tacrolimus (Tac) pharmacogenomics studies have identified common genetic variants that alter Tac troughs and developed specific dosing strategies for specific populations. Known common variants and…
  • 2018 American Transplant Congress

    Sirolimus Use Improves Cancer-Free Survival Following Transplantation: A Single Center 10-Year Analysis

    P. Chen,2 L. Nair,2 A. Ata,2 D. Conti,1 R. Lopez-Soler.1

    1Surgery, Section of Transplantation, Albany Medical College, Albany, NY; 2Surgery, Albany Medical College, Albany, NY.

    Introduction:In previous published results, we showed that the use of Sirolimus-based immunosuppression regimens had equivalent patient and graft 10-year survival compared to historical controls maintained…
  • 2018 American Transplant Congress

    Cognition after Belatacept Conversion

    C. Ogbejesi, E. Cohen, K. Belfield, W. Asch.

    Yale University, New Haven, CT.

    Intro: Kidney Transplant Recipients (KTRs) taking calcineurin inhibitors (CNIs) can experience varying drug toxicities. Less well studied compared to the metabolic consequences, many patients report…
  • 2018 American Transplant Congress

    Outcomes of Early Steroid Withdrawal in 6-Antigen Human Leukocyte Antigen (HLA)-Matched Kidney Transplant Recipients

    H. Champion, K. Holdener, B. Astor, F. Aziz, D. Mandelbrot.

    UW Health, Madison, WI.

    Background: Steroids are often used as part of standard immunosuppressant therapy to help prevent acute rejection in renal transplant patients. However, the long term adverse…
  • 2018 American Transplant Congress

    Estimated GFR for Living Kidney Donor Evaluation before and after Donor Nephrectomy

    Y. Kakuta,1 M. Okumi,1 R. Imamura,2 N. Ichimaru,2 S. Takahara,2 H. Ishida,1 K. Tanabe.1

    1Urology, Tokyo Women's Medical University, Tokyo, Japan; 2Urology, Osaka Graduate School of Medicine, Suita, Osaka, Japan.

    BackgroundKidney transplantation from living donors is an important treatment for patients with kidney failure. An accurate evaluation of renal function must be conducted before and…
  • 2018 American Transplant Congress

    Shortening Length of Post-Operative In-Patient Stay for Living Kidney Donors

    M. Loiselle, H. Bruschwein, J. Jacobs, S. Gulin, T. Rose, H. Arora, R. Nash, A. Toledo, T. Kozlowski.

    Department of Surgery, University of North Carolina, Chapel Hill.

    Purpose. The study analyzes the impact of psychiatric history on postoperative length of hospital stay (LOS) of living kidney donors (LD) and initial assessment of…
  • 2018 American Transplant Congress

    Pinching an Inch in Kidney Transplantation: Subcutaneous Depth as a Risk Factor for Wound Complications

    R. Ruiz, T. Cox, K. Wicklund, N. Jennings, N. Onaca, G. Testa, T. Anthony, H. Fernandez, J. Bayer, G. McKenna.

    Baylor All Saints Medical Center, Fort Worth.

    Wound complications after kidney transplant (KTx) consume valuable resources, including prolonged hospital stays and increased costs. Known risk factors include immunosuppression exposure, diabetes, and obesity…
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