Am J Transplant, Volume 18, Suppl 3 Archives - Page 18 of 211 - ATC Abstracts

2018 American Transplant Congress
Outcomes after HIV+ Liver Transplant: A HOPE in Action Study
C. Durand,¹ M. Bowring,¹ A. Tobian,^1,3 D. Brown,¹ A. Cameron,¹ S. Ottman,¹ K. Oshima,¹ D. Ostrander,¹ A. Redd,¹ S. Huprikar,² B. Haydel,² S. Lerner,² S. Florman,² S. Chandran,⁶ A. Chao,⁶ V. Kirchner,⁷ T. Pruett,⁷ A. Massie,¹ D. Segev.¹
¹JHU, Baltimore; ²Mount Sinai, New York; ³NIH, Bethesda; ⁴UCSF, San Francisco; ⁵UMN, Minneapolis.
The HOPE in Action Pilot Trial (NCT02602262) is assessing the safety and feasibility of HIV+ deceased donor (D+) kidney and liver transplantation for HIV+ recipients…
2018 American Transplant Congress
Impact of Ambulatory Transplant Pharmacy Services on Outcomes and Readmissions in Adult Abdominal Transplant Recipients
K. Joyal,¹ C. Rogers,² M. Cote,² M. Pavlakis,² A. Evenson,² V. Patwardhan,² K. Richards.²
¹Northeastern University, Boston, MA; ²Beth Israel Deaconess Medical Center, Boston, MA.
Over the past two decades, the role of transplant pharmacists (Txp Rx) has expanded following revised guidance from UNOS and CMS. There is little data…
2018 American Transplant Congress
Early Results from USHER: A Pilot Trial of Transplanting HCV-Infected Hearts into HCV-Negative Recipients Followed by Anti-Viral Therapy
R. McLean, P. P. Reese, M. Acker, P. Abt, A. Sicilia, N. Hornsby, P. Atluri, K. R. Reddy, E. Blumberg, V. Van Deerlin, D. S. Goldberg.
UPENN, Philadelphia.
Background: In 2016, over 600 hearts from deceased donors with active or prior hepatitis C virus (HCV) infection were discarded; most were otherwise good quality,…
2018 American Transplant Congress
The Inhibitory Effect of Plasma on Activation of Lymphocytes from Kidney Transplants is Significantly More Severe in Tacrolimus Based Regimen: What Implications for Plasma Exchange Role in Anti-Rejection Therapy?
A. Assounga,^1,2 S. Omarjee.¹
¹Dept of Nephrology, University of KwaZulu-Natal, Durban, South Africa; ²Inkosi Albert Luthuli Central Hospital, Durban, South Africa.
Background:Reduction of lymphocyte proliferation by human plasma has been previously reported. Reduced activation of lymphocytes of patients on immunosuppressive drugs is well documented. However, trial…
2018 American Transplant Congress
Patients Converted to Belatacept Show Different Immunophenotyping Compared with De Novo Belatacept-Treated Patients
M. Rial,¹ F. Caro,² A. Nella,² D. Guerrieri,² L. León,¹ P. Uva,¹ E. Chuluyan,² D. Casadei.¹
¹Instituto de Nefrología, Nephrology, Buenos Aires, Argentina; ²CEFYBO, UBA, CONICET, Buenos Aires, Argentina.
The incidence of adverse clinical events mainly in early, but not late post-transplantation such as an increased rate of acute rejection precludes the use of…
2018 American Transplant Congress
Stress-Related Exosomal MicroRNA Biomarkers Released by Human Islets during Transplantation
P. Saravanan,¹ P. Nguyen,¹ G. Yoshimatsu,¹ C. Chang,¹ C. Darden,¹ R. Bhattacharjee,¹ X. Wang,¹ J. Gu,¹ M. Lawrence,¹ B. Naziruddin.²
¹Baylor Scott & White Research Institute, Dallas; ²Baylor Simmons Transplant Institute, Dallas.
Purpose: Pancreatic islets release noncoding microRNAs (miRNAs) upon damage and stress during islet transplant procedures. In this study, we sought to identify miRNAs released by…
2018 American Transplant Congress
Ex Vivo Lung Perfusion Using the Portable OCS Maintains Endothelial Integrity in the Context of Reduced Severe PGD Rates
B. Wiegmann,¹ R. BellmasSanz,² C. Neudörfl,² C. Kühn,¹ I. Tudorache,¹ M. Avsar,¹ A. Haverich,¹ G. Warnecke,¹ C. Falk.²
¹Department of Cardiothoracic, Transplantation, Vascular Surgery, Hannover Medical School, Hannover, Germany; ²Institute of Transplant Immunology, Hannover Medical School, Hannover, Germany.
PurposeThe INSPIRE trial revealed significant reduction of PGD grade 3, i.e. less ischemia reperfusion injury (IRI) using the Organ Care System (OCS) compared to controls…
2018 American Transplant Congress
Endothelial Progenitor Cell-Derived Extracellular Vesicles Inhibit Kidney Ischemia-Reperfusion Injury through the Transfer of Specific microRNA and mRNA Coding for the Complement Inhibitors CD55, CD59, Factor H and for the Transcription Factor NRF2: Relevance for Delayed Kidney Graft Function
V. Cantaluppi,¹ D. Medica,¹ S. Dellepiane,¹ G. Merlotti,¹ A. Airoldi,¹ M. Quaglia,¹ G. Castellano,² L. Gesualdo,² G. Camussi.³
¹Nephrology and Kidney Transplantation Unit, University of Piemonte Orientale (UPO), Novara, Italy; ²Nephrology, Dialysis and Kidney Transplantation Unit, University of Bari, Bari, Italy; ³Department of Medical Sciences, University of Torino, Torino, Italy.
Complement activation and oxidative cell damage are hallmarks of delayed kidney graft function (DGF) due to ischemia-reperfusion injury (IRI). Endothelial progenitor cells (EPC) protect from…
2018 American Transplant Congress
An Integrative Approach for the Assessment of Peritubular Capillaritis Extent and Score in Microvascular Inflammation – Association with Transplant Glomerulopathy and Graft Loss
N. Kozakowski,¹ H. Herkner,² F. Eskandary,³ M. Eder,³ W. Winnicki,³ G. Bond,³ Ž. Kikić.³
¹Department of Pathology, Medical University of Vienna, Vienna, Austria; ²Department of Emergency Medicine, Medical University of Vienna, Vienna, Austria; ³Division of Nephrology and Dialysis, Department of Medicine III, Medical University of Vienna, Vienna, Austria.
Background:Banff Classification accepts two histomorphological features as surrogates of HLA Antibody-Antigen interaction on renal endothelium: C4d staining and microvascular inflammation scores (MVI sum score:ptc+g≥2) which…
2018 American Transplant Congress
Clinical Response to Salvage Bortezomib Therapy for Antibody Mediated Rejection and Mixed Acute Rejection in a High Immunologic Risk Renal Transplant Population
A. Lichvar, J. Benken, E. Benedetti.
University of Illinois at Chicago, Chicago, IL.
Background: Proteasome inhibitor (PI) containing regimens treat antibody mediated rejection (AMR) and mixed acute rejection (MAR) due to elimination of donor specific antibody (DSA). Commonly,…