Am J Transplant, Volume 18, Suppl 3 Archives - Page 178 of 211 - ATC Abstracts

2018 American Transplant Congress
Inter-Correlations between Psycho-Social Pre-Transplant Determinants of Post-Transplant Kidney Allograft Function
S. Shah, A. Gamilla-Crudo, B. Schreiber, C. Machner, O. Aleter, M. Mujtaba.
Transplant Services, UTMB, Galveston, TX.
Psycho-social factors are common in patients with advanced and end stage kidney disease and they may be associated with post kidney transplant outcomes. The aim…
2018 American Transplant Congress
Long-Term Nonhuman Primate Renal Allograft Survival without Ongoing Immunosuppression in Recipients of Delayed Donor Bone Marrow Transplantation
K. Hotta, T. Oura, A. Dehnadi, M. Matsunami, I. Rosales, R. Smith, R. Colvin, A. Cosimi, T. Kawai.
Center for Transplantation Sciences, Massachusetts General Hospital, Boston, MA.
Background: We have previously reported induction of renal allograft tolerance in nonhuman primates following an initial post-transplant period of conventional immunosuppression (IS) using a nonmyeloablative…
2018 American Transplant Congress
Post-Transplant High Dose Cyclophosphamide Treatment Induces Thymus-Independent Immune Tolerance of Vascularized Composite Allografts via Complete Depletion of the Alloreactive TCR Repertoire.
G. Furtmüller,¹ B. Oh,¹ J. Sidhom,² M. Fryer,¹ V. Malek,¹ X. Zhou,¹ D. Cooney,¹ C. Brayton,³ J. Dodd-o,⁴ S. Ganguly,² G. Raimondi,¹ W. Lee,¹ L. Luznik,² G. Brandacher.¹
¹Plastic and Reconstructive Surgery, Johns Hopkins University, Baltimore, MD; ²Sidney Kimmel Cancer Center, Johns Hopkins University, Baltimore, MD; ³Department for Comparative Pathobiology, Johns Hopkins University, Baltimore, MD; ⁴Department of Anesthesiology, Johns Hopkins University, Baltimore, MD.
Background: Treatment with PT/Cy in the setting of combined donor bone marrow transplantation and VCA has shown encouraging results with regards to chimerism induction and…
2018 American Transplant Congress
Tipping the “Immune Balance” towards Tolerance by Specific and Systematic Depletion of Donor and Host Effector Cells
R. Bascom, K. Tao, L. West.
Alberta Transplant Institute, Canadian National Transplant Research Program, University of Alberta, Edmonton, Canada.
Purpose: To induce robust transplant tolerance in neonates with fully allogeneic spleen and bone marrow cells (SC/BMC) it is crucial to define the complex interplay…
2018 American Transplant Congress
The Relative Immunogenicity of HLA Mismatches in Adult Liver Transplant Recipients
V. Jucaud,¹ A. Shaked,² M. DesMarais,³ P. Sayre,³ M. Everly.¹
¹Terasaki Research Institute, Los Angeles, CA; ²University of Pennsylvania, Philadelphia, PA; ³Immune Tolerance Network, Seattle, WA.
Determining the immunogenicity of HLA mismatches (MM) may help preventing the appearance of de novo DSA (dnDSA) and avoiding antibody-mediated injuries.We studied the development of…
2018 American Transplant Congress
An In Vitro Model of Human Antibody-Mediated Rejection Depicts Key Role for NK Cells
L. Hidalgo,¹ M. Racape,² A. Loupy,² C. Lefaucheur.²
¹Lab. Med. and Pathology, University of Alberta, Edmonton, AB, Canada; ²Paris Cardiovascular Research Center INSERM, Paris, France.
AIM: Antibody-mediated rejection (ABMR) is the leading cause of kidney allograft loss but its immune mechanisms are incompletely understood. We sought to examine key interactions…
2018 American Transplant Congress
Peripheral but Not Follicular T Helper Cells Are Activated by Allogeneic Human Endothelial Cells under IRI-Like Conditions and Promote Donor Specific Antibody
W. Fu,¹ P. Yoo,² J. Pober,³ D. Jane-wit.¹
¹Cardiovascular Medicine, Yale School of Medicine, New Haven, CT; ²Surgery, Yale School of Medicine, New Haven, CT; ³Immunobiology, Yale School of Medicine, New Haven, CT.
Background: Perioperative ischemia reperfusion injury (IRI) is a consequence of solid organ allograft transplantation that primes the graft for future rejection.Methods: We developed an in…
2018 American Transplant Congress
What Threshold MFI is the Luminex 1:8 Dilution the Poor Man's C1q for Patients Awaiting Heart Transplant?
M. Kittleson, J. Patel, E. Kransdorf, R. Levine, S. Dimbil, D. Geft, D. Chang, L. Czer, J. Kobashigawa.
Cedars Sinai Medical Center, Los Angeles.
Purpose: Heart transplant candidates are evaluated for anti-HLA antibodies by Luminex single-antigen bead testing to avoid donors that may harbor antigens that these antibodies are…
2018 American Transplant Congress
The Secret is Selection of Muscular Dystrophy for Success after Heart Transplant
M. Kittleson, J. Patel, E. Kransdorf, R. Levine, S. Dimbil, D. Geft, D. Chang, L. Czer, J. Kobashigawa.
Cedars Sinai Medical Center, Los Angeles.
Purpose: Patients with muscular dystrophy may have an associated cardiomyopathy, resulting in advanced heart failure requiring transplantation. However, the skeletal muscle dysfunction can result in…
2018 American Transplant Congress
Pancreas Decellularization Protocol – Comparison of Methods
A. Berman, K. Karzynski, M. Serwanska-Swientek, N. Pilka, M. Klak, K. Kosowska, J. Cichon, F. Ambrozkiewicz, M. Wszola.
Foundation of Research and Science Development, Otwock, Poland.
Background: Whole organ decellularization is gaining a lot of popularity since its development in tissue engineering. It is a process which allows to create complex…