Am J Transplant, Volume 18, Suppl 3 Archives - Page 178 of 211 - ATC Abstracts

2018 American Transplant Congress
Effect of Donor-Recipient Gender-Mismatch on Long Term Function after Pancreas Transplantation
F. Messner,¹ C. Bösmüller,¹ M. Maglione,¹ M. Riedmann,² R. Oberhuber,¹ B. Cardini,¹ T. Resch,¹ S. Schneeberger,¹ C. Margreiter.¹
¹Visceral, Transplant and Thoracic Surgery, Medical University of Innsbruck, Innsbruck, Austria; ²Medical Statistics, Informatics and Health Economics, Medical University of Innsbruck, Innsbruck, Austria.
Background: Several studies in solid organ transplantation have shown a correlation between gender-match and risk of graft loss. In this study we aimed to analyze…
2018 American Transplant Congress
The Effect of Steroid Maintenance in Recipients with Pancreas Transplant Alone: A Single Center Experience
J. Choi, J. Jung, H. Kwon, S. Shin, Y. Kim, D. Han.
Division of Kidney and Pancreas Transplantation, Department of Surgery, Asan Medical Center, University Ulsan College of Medicine, Seoul, Korea.
Background: In solid organ transplantation, the use of steroids for maintenance therapy is common. However, the appropriateness of steroid maintenance or withdrawal in pancreas transplantation…
2018 American Transplant Congress
Outcomes from Brain Death Donors with Cardiac Arrest Accepted for Pancreas Transplantation
P. Ventura-Aguiar,¹ J. Ferrer,² D. Paredes,³ C. Rodriguez,³ C. Fontdevilla,² E. Esmatjes,⁴ J. Garcia-Valdecasas,² F. Oppenheimer,¹ F. Diekmann,¹ M. Ricart.¹
¹Nephrology and Kidney Transplant Department, Hospital Clinic, Barcelona, Spain; ²Hepatobiliopancreatic and Liver Transplant Department, Hospital Clinic, Barcelona, Spain; ³Organ Transplantation Coordination Department, Hospital Clinic, Barcelona, Spain; ⁴Diabetes Unit, Department of Endocrinology and Nutrition, Hospital Clinic, Barcelona, Spain.
Donor selection has a major impact on pancreas transplantation. Cardiac arrest and hypoxemia produce an insult to endothelial cell and may increase the risk of…
2018 American Transplant Congress
Improving and Delivering Medical Education about Organ Donation and Transplantation to Medical Students Could Play a Fundamental Role in Organ Donation Expansion: Its Time to Get the Basics Right.
A. Ghazanfar, E. Vyra.
Transplant Surgery, St Georges University Hospitals NHS Foundation Trust, London, United Kingdom.
Background: Education and knowledge about organ donation and transplantation are the most important tools required by all doctors to become ambassador for it irrespective of…
2018 American Transplant Congress
Type-1 Interferon Impairs the Immunoregulatory Activity of IL-10: Understanding the Mechanisms of Abrogation of Transplant Tolerance
M. Iglesias, A. Arun, M. Chicco, B. Lam, V. Ivanova, W. Lee, G. Brandacher, G. Raimondi.
Plastic Surgery, Johns Hopkins UIniversity, Baltimore, MD.
A growing body of evidence shows that induction of long term transplant survival by costimulation blockade (CoB) regimens is impaired by inflammatory responses (e.g. engagement…
2018 American Transplant Congress
Prolongation of Skin Allograft Survival through Dietary Supplementation of Ayrl Hydrocarbon Receptor Ligands
A. Afrazi, L. Owens, J. Fechner, C. O'Driscoll, J. Mezrich.
Transplant Surgery, University of Wisconsin, Madison, WI.
The Aryl Hydrocarbon Receptor (AHR) is a cytosolic transcription factor with numerous endogenous and xenobiotic ligands playing a key role in a number of cellular…
2018 American Transplant Congress
Donor T Cells Undermine the Graft-Protective Effect of DST Plus Anti-CD154
M. Iglesias, M. Chicco, W. Lee, G. Brandacher, G. Raimondi.
Plastic Surgery, Johns Hopkins University, Baltimore, MD.
Costimulation blockade (CoB) regimens are a promising immunomodulatory strategy to prevent transplant rejection. However, their efficacy is affected by multiple factors, including still unknown ones.…
2018 American Transplant Congress
Thymic Irradiation as a Maneuver for Repertoire Exchange in Costimulatory-Blockade-Based Immunotherapy
M. Mulvihill,¹ B. Ezekian,¹ Q. Gao,¹ K. Samy,¹ R. Davis,¹ F. Leopardi,¹ W. Giles,² F-.F. Yin,² C. Willett,² B. Collins,¹ A. Kirk.¹
¹Department of Surgery, Duke University, Durham, NC; ²Department of Radiation Oncology, Duke University, Durham, NC.
Background All successful, prospective clinical tolerance-induction strategies have employed thymic irradiation to achieve chimerism. However, evidence suggests durable chimerism is not required to attain tolerance.…
2018 American Transplant Congress
Human Endothelial-Like Cells Transdifferentiated from Peripheral CD14⁺ Monocytes Inhibit T Cells in Response to Allo-Stimulation
Y. Tanaka, H. Ohdan.
Gastroenterological and Transplant Surgery, Hiroshima University, Hiroshima, Japan.
We have previously demonstrated that the endothelial cells located in immune-privilege sites, such as livers, suppress T-cells in response to both of direct and indirect…
2018 American Transplant Congress
Heart Transplant across Low or Moderate Level Donor-Specific Antibodies Have Acceptable Outcome
M. Olymbios, J. Patel, R. Levine, S. Dimbil, M. Kittleson, M. Rafiei, X. Zhang, J. Kobashigawa.
Cedars Sinai Medical Center, Los Angeles.
Purpose: The presence of pre-transplant donor specific antibodies (DSA) can reduce the likelihood of a patient (pt) obtaining a compatible donor heart. The proportion of…