Am J Transplant, Volume 18, Suppl 3 Archives - Page 178 of 211 - ATC Abstracts

2018 American Transplant Congress
Evolutive Analysis of a 20-Year Pancreas Transplant Program
M. Perosa,¹ J. Branez,¹ L. Mota,¹ H. Noujaim,¹ B. Zeballos,¹ L. Ianhez,¹ L. Alvim,¹ D. Machado,¹ C. Watanabe,¹ F. Sergi,¹ M. Paredes,¹ T. Genzini-Miranda,² A. Silvestre,³ G. Martinho,⁴ T. Genzini.¹
¹Abdominal Organ Transplantation, Leforte Hospital, Sao Paulo, Brazil; ²Medical School, PUC Sorocaba, Sorocaba, Sao Paulo, Brazil; ³Medical School, Sao Camilo, Sao Paulo, Brazil; ⁴Medical School, Ciências Médicas Santa Casa, Sao Paulo, Brazil.
There is a worldwide trend towards a reduction in the annual number of pancreas transplants (PT). In Brazil, only two centers have performed more than…
2018 American Transplant Congress
Comparison of Glycemic Control in Type 1 and Type 2 Diabetic Patients after Pancreas Transplantation
O. Andacoglu,¹ A. Murthy,² J. Ahn,³ J. Verbesey,¹ S. Ghasemian,¹ M. Cooper,¹ P. Abrams.¹
¹Transplant, Medstar Georgetown Transplant Institute, Washington, DC; ²School of Medicine, Georgetown University, Washington, DC; ³Biopstatistics, Georgetown University, Washington, DC.
Background: Pancreas transplant remains controversial for type 2 diabetic (T2DM) patients.Aim: To compare glycemic control following pancreas transplantation between T1 and T2 DM patients.Methods: 52…
2018 American Transplant Congress
Trends in Safety Reporting to UNOS Related to Non-Recovery, Discard, or Delay
A. Doyle,¹ R. Urban,² S. Tlusty,² M. Marvin,³ E. Hollinger,⁴ D. Marshman,⁵ M. Green.⁶
¹Medicine, University of Virginia, Charlottesville, VA; ²UNOS, Richmond, VA; ³Surgery, Geisinger, Danville, PA; ⁴Surgery, Rush Medical Center, Chicago, IL; ⁵LifeLink Foundation, Norcross, GA; ⁶Surgery, University of Pittsburgh, Pittsburgh, PA.
The UNOS Operations and Safety Committee is charged with reviewing reported patient safety situations, identifying safety gaps, addressing high frequency and high impact events, and…
2018 American Transplant Congress
Evaluating Transplant Quality Staffing Models via a National Survey
M. Cook, I. Feurer, L. Smith, S. Rega, E. Zavala.
Vanderbilt Transplant Center, VUMC, Nashville, TN.
The 2007 CMS Final Rule included expectations that transplant centers implement data-driven quality assessment and performance improvement (QAPI) programs. Currently, insufficient data exists to guide…
2018 American Transplant Congress
LAG-3 Deletion Upregulates Memory in a Dendritic Cell-Dependent Process
S. Gibney,¹ M. Efre,¹ T. Ashry,¹ C. Yang,¹ T. O'Shea,^1,2 R. White,² P. Russell,¹ J. Madsen,¹ R. Colvin,² A. Alessandrini.^1,2
¹Center for Transplantation Sciences, Department of Surgery, Massachusetts General Hospital, Boston, MA; ²Department of Pathology, Massachusetts General Hospital, Boston, MA.
Introduction. Cardiac transplantation is critical for management of severe heart failure, but cardiac allografts frequently undergo chronic T-cell-mediated allograft rejection. Our research demonstrates that Lymphocyte…
2018 American Transplant Congress
Thymus Co-Transplantation Promotes Donor-Specific Tolerance in Allogeneic Heart Transplantation
J. Kwun,¹ J. Li,² C. Rouse,³ J. Park,¹ A. Kirk,¹ L. Markert.²
¹Surgery, Duke University, Durham, NC; ²Pediatrics, Duke University, Durham, NC; ³Laboratory Animal Resources, Duke University, Durham, NC.
Background: Allogeneic thymus has been investigated to achieve donor-specific tolerance in organ transplantation. Often thymus co-transplantation induces long-term graft survival in immunodeficient and total lymphoid…
2018 American Transplant Congress
The LncRNA MALAT1 Induces Tolerogenic DCs and Antigen Specific Tregs Subsequently Mediating Cardiac Allograft Tolerance in Mice via MiR-155/DC-SIGN/IL10 Axis
M. Zhang,^1,2 J. Wu,^1,2 H. Zhang,^1,2 M. Liu,^1,2 Y. Zheng,^1,2 X. Jin,^1,2 S. Li,^1,2 Q. Zhao,^1,2 X. Liu,^1,2 Y. Sun,^1,2 B. Yu.^1,2
¹Department of Cardiology, The Second Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang, China; ²The Key Laboratory of Myocardial Ischemia, Harbin Medical University, Ministry of Education, Harbin, Heilongjiang, China.
Background: Tolerogenic dendritic cells(DCs) by shaping T cells immunity and inducing Tregs play critical roles in the induction of allograft tolerance in transplantation. Long noncoding…
2018 American Transplant Congress
Regulation of Indoleamine 2,3-Dioxygenase in Porcine Kidney Transplants
Y. Wang,¹ X. Fang,¹ D. Kleven,¹ C. Ho,² S. Nahman,^1,3 T. Merchen.¹
¹Augusta University, Augusta, GA; ²Gift of Life Michigan, Ann Arbor, MI; ³Norwood VAMC, Augusta, GA.
Indoleamine 2,3-dioxygenase (IDO) is an endogenous immunosuppressant exerting its effects through tryptophan depletion and kynurenine generation. Kynurenine 3-monooxygenase (KMO) is a downstream enzyme from IDO…
2018 American Transplant Congress
Normothermic Ex-Vivo Kidney Perfusion Restores the Genetic Profile of Marginal Kidney Grafts Subjected to Warm Ischemia
P. Urbanellis,¹ M. Hamar,¹ I. Linares,¹ D. Kollmann,¹ S. Ganesh,¹ R. John,¹ P. Yip,¹ I. Mucsi,¹ A. Ghanekar,¹ D. Bagli,² A. Konvalinka,¹ D. Grant,¹ L. Robinson,² M. Selzner.¹
¹University Health Network, Toronto, ON, Canada; ²SickKids Hospital, Toronto, ON, Canada.
Background: Increasing evidence demonstrates the superiority of normothermic ex-vivo kidney perfusion (NEVKP) over cold storage (CS) for marginal renal grafts. To account for this improvement,…
2018 American Transplant Congress
The Overriding Importance of HLA-DR Donor-Specific Antibody That is Correlated to CAV after Heart Transplant
E. Kransdorf, J. Patel, M. Kittleson, S. Dimbil, R. Levine, D. Geft, D. Chang, L. Czer, J. Kobashigawa.
Cedars Sinai Medical Center, Los Angeles.
Purpose: Class II donor specific anti-HLA antibodies (DSA) have been correlated to subsequent CAV development. More specifically, HLA-DQ has been most reported for CAV development.…