Am J Transplant, Volume 18, Suppl 3 Archives - Page 173 of 211 - ATC Abstracts

2018 American Transplant Congress
Should More Donation after Cardiac Death Livers Be Used in Pediatric Transplantation?
C. Hwang,¹ S. Levea,² M. MacConmara.¹
¹Surgery, UT Southwestern Medical Center, Dallas, TX; ²Medicine, UT Southwestern Medical Center, Dallas, TX.
Introduction: Multiple strategies exist to increase the organ pool for livers in pediatric recipients, including using split livers, high risk livers, and donation after cardiac…
2018 American Transplant Congress
Risk Factors for Chronic Opioid Use after Liver Transplantation
J. Fleming, D. Taber, B. O'Brien, N. Patel, N. Pilch, R. Gilbert, L. Wilson, Z. Elmaasarani, S. Ball, P. Mauldin, P. Baliga.
MUSC, Charleston, SC.
Opioid use is associated with increased readmissions and mortality in the liver transplant (OLTx) population. The aim of our study was to identify risk factors…
2018 American Transplant Congress
Identification of Anti-Inflammatory and Pro-Inflammatory Gut Microbiota That Determine Graft Survival
Y. Xiong, C. Brinkman, L. Hittle, W. Fricke, E. Mongodin, J. Bromberg.
UMB, MD.
Introduction: The gut microbiota induce and train the host immune system. Whether microbiota from contrasting environments of colitic or pregnant mice are pro- or anti-inflammatory…
2018 American Transplant Congress
IL-17 is Critical for Airway Epithelial Injury after Transplantation
R. Zhang,¹ H. Fang,¹ Q. Chen,² J. Ochando,³ Y. Ding,¹ J. Xu.¹
¹Department of Immunology, Capital Medical University, Beijing, China; ²Department of Thoracic Surgery, Chaoyang Hospital, Beijing, China; ³Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY.
Background: Obliterative bronchiolitis is the major obstacle limiting long-term allograft survival of lung transplantation. Airway epithelium is the primary target in obliterative airway diseases. Th17…
2018 American Transplant Congress
Estimated Impact of the Number of Simultaneous Offers on Kidney Delay and Discard
M. Mankowski,¹ S. Raghavan,³ C. Holscher,² M. Kosztowski,² D. Segev,² S. Gentry.⁴
¹King Abdullah University of Science and Technology, Thuwal, Saudi Arabia; ²Johns Hopkins University, Baltimore; ³University of Maryland, College Park; ⁴US Naval Academy, Annapolis.
Following local decline of a recovered kidney, making regional and national offers in larger simultaneous batches might decrease discards. We simulated varying batch sizes for…
2018 American Transplant Congress
The Etiologies and Impact of Hospitalization in Older Kidney Transplant Recipients
M. Posadas Salas, R. Rodriguez, P. Amaechi, V. Rao, D. Taber.
Medical University of South Carolina, Charleston, SC.
Older kidney transplant recipients (KTR) face challenges of post-transplant complications related to frailty and comorbidities. They are particularly vulnerable to infectious complications. This study elucidates…
2018 American Transplant Congress
The Risk Factors of Acute Rejection in Patients with BK Nephropathy after the Reduction of Immunosuppression
C. Baek,¹ H. Kim,¹ W. Yang,¹ D. Han,² S-.K. Park.¹
¹Department of Internal Medicine, Division of Nephrology, Asan Medical Center, Seoul, Republic of Korea; ²Department of Surgery, Asan Medical Center, Seoul, Republic of Korea.
Background: BK nephropathy (BKN) affects graft function and increases the risk of graft failure. The reduction of immunosuppression is the main treatment for BKN. However,…
2018 American Transplant Congress
Cost Effectiveness of Lifelong Medicare Immunosuppressant Drug Coverage for Kidney Transplant Recipients in the Current Era
M. Kadatz,¹ J. Gill,² J. Gill,² K. Scott.³
¹Clinician Investigator Program, University of British Columbia, Vancouver, BC, Canada; ²Division of Nephrology, Department of Medicine, University of British Columbia, Vancouver, BC, Canada; ³Division of Nephrology, Department of Medicine, University of Alberta, Edmonton, AB, Canada.
While there is no Medicare time limit for dialysis patients, kidney transplant recipients lose their Medicare coverage 36 months after they receive their transplant. The…
2018 American Transplant Congress
Recipient IFNAR1 Signaling Supports Costimulation Independent Rejection by Promoting T Cell Activation
D. Mathews, A. Ghosh, Y. Dong, K. Polireddy, A. Stephenson, C. Breeden, Y. Liu, A. Adams.
Department of Surgery, Emory University, Atlanta, GA.
Costimulation blockade (CoB) is a promising strategy for more targeted/less toxic transplant immunosuppression which has led to the first improvement in long-term outcomes for transplant…
2018 American Transplant Congress
Curative Correction of FAH Deficiency by Chimeric Stem Cells Transplantation
D. Joo,^1,2 E. Nelson,¹ Y. Zhang,¹ B. Amiot,¹ S. Ho,³ C. Lancto,⁴ D. Carlson,⁴ L. Queiroz,⁵ S. Nyberg.¹
¹Division of Transplant Surgery, Mayo Clinic, Rochester, MN; ²Department of Surgery, Yonsei University College of Medicine, Seoul, Korea; ³Department of Pathology, University of Michigan, Ann Arbor, MI; ⁴Recombinetics Inc, Saint Paul, MN; ⁵International Center for Biotechnology, Cooperative Resources International, Mount Horeb, WI.
Fumarylacetoacetate hydrolase (FAH) deficient pigs have been proposed as surrogate hosts for large scale in vivo expansion of normal FAH+ hepatocytes. However, immunologic rejection prevents…