ATC Abstracts

American Transplant Congress abstracts

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  • 2018 American Transplant Congress

    Inflammatory Frailty Index and Mortality after Kidney Transplantation

    C. Haugen, H. Ying, M. McAdams-DeMarco, D. Segev.

    Surgery, JHU, Baltimore.

    Frailty is a phenotype of decreased physiologic reserve and is associated with a pro-inflammatory state. Fried frailty (slow walk speed, weight loss, decreased grip, low…
  • 2018 American Transplant Congress

    Use of Hepatitis-C Treatments after Kidney Transplantation: Impact of the Direct-Acting Antiviral Era

    K. Lentine, D. Axelrod,2 R. Bloom,3 H. Xiao,1 D. Segev,4 T. Alhamad,5 H. Randall,1 R. Ouseph,1 V. Dharnidharka,5 D. Brennan,4 N. Lam,6 A. Naik,7 G. Hess,8 B. Kaiske,9 M. Schnitzler.1

    1Saint Louis U, St. Louis; 2Lahey, Burlington; 3U Penn, Philadelphia; 4Johns Hopkins, Baltimore; 5Washington U, St. Louis; 6U Alberta, Edmonton, Canada; 7U Michigan, Ann Arbor; 8Hennepin, Minneapolis; 9Symphony Health, Conshohocken.

    Hepatitis C virus (HCV) infection in kidney transplant (KTx) donors or recipients has correlated with adverse outcomes, partly due to limited treatment options. Development of…
  • 2018 American Transplant Congress

    Feasibility of a National Class II Matching Strategy for Pediatric Kidney Transplant Candidates

    T. Blydt-Hansen,1 W. Klement,2 K. Tinckam,3 J. Gill.1

    1University of British Columbia, Vancouver, Canada; 2Canadian Blood Services, Ottawa, Canada; 3University of Toronto, Toronto, Canada.

    Antibody-mediated rejection (AMR) is a major concern for allograft failure, which could be mitigated by allocation of Class II matched donors. Since children have priority,…
  • 2018 American Transplant Congress

    The Transplant-Death Index: A Novel Method to Identify Disenfranchised Liver Transplant Waitlist Candidates

    M. Kueht, J. Goss, N. Galvan, A. Rana.

    Surgery, Division of Abdominal Transplantation, Baylor College of Medicine, Houston, TX.

    The transplant field is seeing a shift in outcome priorities from just 1-year survival to include waitlist metrics such as the transplant rate. Identifying disenfranchised…
  • 2018 American Transplant Congress

    Prevention of an Adaptive Immune Response by FDA-Approved Immunosuppressive Agents in Baboons with Pig Artery Patch Xenografts

    T. Yamamoto,1 H. Hara,1 L. Wang,1 Q. Li,1 J. Li,1 H. Zhou,1 D. Eckhoff,1 A. Tector,1 D. Ayares,2 D. Cooper,1 H. Iwase.1

    1Xenotransplantation Program, Department of Surgery, University of Alabama at Birmingham, Birmingham; 2Revivicor, Blacksburg.

    Background: In the pig-to-baboon artery patch model with no immunosuppressive therapy, a graft from a GTKO pig elicits a significant anti-nonGal IgG response, indicating sensitization…
  • 2018 American Transplant Congress

    IgA Recurrence in a Single Center with a Protocol Biopsy Program

    M. Merzkani, N. Lepori, M. El Ters, F. Cosio, H. Amer.

    Mayo Clinic, Rochester, MN.

    The objective of this study was to determine the rate of recurrence of IgA nephropathy in our program aided by protocol biopsies and protocol driven…
  • 2018 American Transplant Congress

    Tissue Talks: Graft´s Histological Findings 10 Years after Belatacept or CNI

    G. Mondragon-Ramirez,1 N. Uribe-Uribe,2 J. Arreola-Guerra,5 R. Reyes-Acevedo,5 M. Vilatoba,3 J. Furuzawa-Carballeda,4 A. Lopez-Toledo,1 G. Mondragon-Salgado,1 J. Alberu.3

    1Inst Mex de Trasplantes, Cuernavaca, Mexico; 2Pathology, Inst Nal de C. Médicas y Nutrición SZ, Mexico City, Mexico; 3Transplantation, Inst Nal de C. Médicas y Nutrición SZ, Mexico City, Mexico; 4Immunology, Inst Nal de C. Médicas y Nutrición SZ, Mexico City, Mexico; 5Transplantation, C Hospital Miguel Hidalgo, Aguascalientes, Mexico.

    The BENEFIT study demonstrated that 7 yrs after kidney transplantation (KT), mean eGFR, patient and graft survival, were significantly higher in the belatacept group than…
  • 2018 American Transplant Congress

    Evolving Etiologies for Readmissions and Their Impact on Graft Survival in Kidney Transplantation

    D. Taber, N. Pilch, Z. Su, C. Mardis, J. Fleming, N. Patel, H. Meadows, P. Mauldin, V. Rao, D. Dubay.

    MUSC, Charleston, SC.

    Background: Although readmissions after kidney transplant are a well-known risk factor for graft loss, it is unclear if certain etiologies are associated with poorer outcomes…
  • 2018 American Transplant Congress

    Impact of Local Liver Supply on Liver Offer Acceptance

    M. Bowring,1 S. Zhou,1 A. Massie,1 S. Gentry,1,2 D. Segev.1

    1JHU, Baltimore; 2US Naval Academy, Annapolis.

    Geographic disparity in access to deceased-donor liver transplantation is well described. The available liver supply in a DSA may affect patient and provider decisions on…
  • 2018 American Transplant Congress

    T Cell-Mediated Rejection Poses Greater Risk to Graft Survival Than Antibody-Mediated Rejection in Heart Transplants

    M. Parkes, K. Famulski, P. Halloran, The INTERHEART Study Group.

    University of Alberta, Edmonton, Canada.

    Purpose: In kidney transplants, failure post-biopsy is associated with acute injury transcript expression reflecting the histologically silent tissue response-to-wounding (JCI 120:1862) and antibody-mediated rejection (ABMR),…
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