2018 American Transplant Congress
The Role of Donor-Derived Cell-Free DNA in Identification of Injury in Kidney Allografts with Antibody-Mediated Rejection and De Novo DSA
Objectives: To evaluate the capacity of donor-derived cell-free DNA (dd-cfDNA) in the identification of injury in kidney allografts with antibody-mediated rejection and de novo DSA.Methods:…2018 American Transplant Congress
Allograft Function after 12 Months with Everolimus Plus Either Tacrolimus or Cyclosporine Compared to a Standard Regimen of Tacrolimus with MPA in De Novo Renal Transplant Recipients: The ATHENA Study
1Athena Study Group, Germany; 2Athena Study Group, France; 3Novartis, Pharma, Germany.
The ATHENA study was designed to compare efficacy, safety and outcomes on renal function [GFR] of everolimus [EVR] combined with tacrolimus [TAC] or cyclosporine A…2018 American Transplant Congress
Eplet Mismatches and De Novo Donor Surface Antibody Development in Pediatric Renal Transplant Recipients
1Seattle Children's Hospital, Seattle; 2Bloodworks Northwest, Seattle; 3UW Medicine, Seattle.
Background: De novo donor surface antibody (dnDSA) development is arguably the first step in the natural history of allograft injury secondary to humoral alloimmunity. This…2018 American Transplant Congress
Higher Early Post-Liver Transplant Mortality in Recipients with Severe Alcoholic Hepatitis versus Alcoholic Cirrhosis
INTRODUCTIONThe American Consortium of Early Liver Transplantation for Alcoholic Hepatitis (ACCELERATE-AH) is a multicenter cohort from 8 UNOS regions studying early liver transplant (LT) for…2018 American Transplant Congress
Development of a Novel Assay System for Ex Vivo T-Cell Mediated Rejection Responses in Intestinal Grafts
In intestinal transplantation, the intestinal allograft (IA) presents a formidable challenge for control of alloimmune responses due to constitutive MHC class II expression by intestinal…2018 American Transplant Congress
Hematopoietic Cell Kinase (Hck) Regulates Effector and Regulatory T Cell (Treg) Function
Background: We found that upregulation of Hck mRNA expression, an Src family tyrosine kinase, in surveillance graft biopsies of kidney transplant patients associates with an…2018 American Transplant Congress
The BEST Trial: A Prospective Randomized Multicenter Trial of Belatacept-Based CNI- and Corticosteroid-Free Immunosuppression
Previous large multicenter belatacept (BELA)-based CNI- and steroid-free immunosuppressive trials have not enrolled to completion due to safety concerns. The BEST Trial (Belatacept-based Early Steroid…2018 American Transplant Congress
Kidney Transplant Patients with Polycystic Kidney Disease Have a Lower Risk of Post-Transplant BK Infection Compared to Other Causes of ESRD
University of Wisconsin Madison, Madison, WI.
Purpose: Polyomavirus-associated nephropathy is associated with high rates of allograft loss among kidney transplant patients. Whether the cause of native end-stage renal disease (ESRD) impacts…2018 American Transplant Congress
Factors Associated with the Development of Chronic Kidney Disease after Liver Transplantation
Liver Unit, Queen Elizabeth Hospital, Birmingham, United Kingdom.
BackgroundRenal dysfunction is a common complication after liver transplantation. The increased use of DCD livers has been associated with postoperative acute kidney injury (AKI). However,…2018 American Transplant Congress
Comparing Outcomes between Induction Immunosuppressive Therapies in Simultaneous Heart/Kidney Transplantation
Virginia Commonwealth University, Richmond.
Introduction: There is no published data on the risks and benefits of Induction immunosuppression in simultaneous heart/kidney transplant (SHKT) patients.Methods: We analyzed all SHKT performed…
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