2018 American Transplant Congress
Early Sub-Clinical and Clinical TCMR Are Associated with Progressive Renal Allograft Dysfunction
Background: The clinical course and significance of early sub-clinical (SCR) and clinical TCMR (ACR) vs. no rejection (NR) is unclear. In this prospective study, we…2018 American Transplant Congress
Liver Transplants from Older Donors Have Worse Outcomes in Elderly Recipients with Renal Dysfunction
Background: Most end stage liver disease patients suffer from concomitant renal insufficiency. We aimed to study influence of donor age on outcomes in elderly liver…2018 American Transplant Congress
Assessment of Donor Specific Anti-HLA Antibodies throughout SLK Transplantation
Simultaneous Liver-Kidney transplantation provides a mechanism to protect the transplanted kidney from recognition by the recipient's immune response compared to solitary kidney transplant alone. High…2018 American Transplant Congress
Pregnancy Outcomes after Living Liver Donation
Introduction: Women who have previously donated a kidney are at increased risk of pre-eclampsia. Nearly half of living liver donors are women of child-bearing age.…2018 American Transplant Congress
Enhancement of Muscle Regeneration and Function via Transplantation of Human Dystrophin Expressing Chimeric Cells as a Novel Myoblast Stem-Cell Based Therapy
PURPOSE: Allogeneic myogenic stem cell transplantation aims to restore muscle tissue after traumatic loss or to treat muscular dystrophies. Limited engraftment due to allogeneic rejection…2018 American Transplant Congress
Closing Pandora's Box: An Evidence Based Approach to Opioid-Tolerant Patients Following Transplantation. The Case for IV Methadone
Department of Surgery, Beaumont Health, Royal Oak, MI.
The purpose of this study is to explore the use of parenteral methadone in opioid-tolerant patients who are status-post transplantation. As an alternative to traditional…2018 American Transplant Congress
Depressive Symptoms, Medication Nonadherence, and Clinical Outcomes Following Lung Transplantation
Background:Elevated depressive symptoms have been associated with worse clinical outcomes following lung transplantation, including mortality. Few studies, however, have examined the mechanisms or clinical correlates…2018 American Transplant Congress
Liver Preservation with Machine Perfusion and a New Human-Derived Hemoglobin-Based Oxygen Carrier Solution (HDHBOC)
1VirTech Bio, Inc, Natick, MA; 2University of Pittsburgh, Pittsburgh, PA.
Introduction: Machine perfusion (MP) is becoming the new standard for liver preservation following the successful implementation of devices for kidney and lung preservation ex-vivo. Liver…2018 American Transplant Congress
Polyclonal Cellular Immune Function is Dose-Dependently Inhibited by Immunosuppressive Drugs but Has Limited Value in Predicting Infection or Rejection Episodes
1Saarland University, Homburg/Saar, Germany; 2Saarland University, Homburg/Saar, Germany.
Background: Dosage of immunosuppressive drugs in transplant patients must be balanced to prevent graft rejection and infectious complications. Knowledge on general immune function may therefore…2018 American Transplant Congress
Ultra Low Dose of IL-2 Produces Long-Term Drug-Free Survival of Cynomolgus Islets Allografts
1Medicine and Surgery, Beth Israel Deaconess Medical Center, Boston, MA; 2Surgery, MGH, Boston, MA.
Therapeutic principles established in non-human transplant models have value for clinical application despite cost related limitations on sample size. We have tested new therapies in…
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