Am J Transplant, Volume 18, Suppl 3 Archives - Page 17 of 211 - ATC Abstracts

2018 American Transplant Congress
Time in Therapeutic Range Predicts DSA Development and Acute Rejection in Kidney Recipients with High Tacrolimus Coefficient of Variation
S. Davis, J. Gralla, P. Klem, A. Wiseman, J. Cooper.
University of Colorado, Aurora, CO.
High tacrolimus trough coefficient of variation (TAC CV) has been associated with an increased risk of de novo donor-specific antibody (dnDSA) and acute rejection (AR).…
2018 American Transplant Congress
What Deceased Donors Do KPD Candidates Accept?
A. Toll,¹ R. Leishman,¹ V. Casingal,² M. Aeder,³ T. Sandholm,⁴ N. Turgeon.⁵
¹UNOS, Richmond, VA; ²Carolinas HealthCare Sys, Charlotte, NC; ³Univ Hosp Med Ctr, Cleveland, OH; ⁴Carnegie Mellon Univ, Pittsburgh, PA; ⁵Emory Univ, Atlanta, GA.
Background: Possible utilization of deceased donors (DDs) to initiate KPD chains has been of interest to the transplant community. OPTN KPD candidates are required to…
2018 American Transplant Congress
Liver Transplant Survival Index for Recipients with High MELD Score: A Model for Post-Transplant Survival in Severely Ill Patients
J. Steggerda,¹ M. Bloom,¹ C. Bresee,² D. Malinoski,³ A. Klein,¹ K. Kim.¹
¹Surgery, Cedars-Sinai Medical Center, Los Angeles, CA; ²Biostatistics, Cedars-Sinai Medical Center, Los Angeles, CA; ³Surgery, Oregon Health Science University, Portland, OR.
Background: SHARE-35 prioritizes patients with MELD scores ≥35 for regional sharing of liver allografts. Because this policy incentivizes transplantation of sicker patients, this study examines…
2018 American Transplant Congress
Enteric Conversion after Bladder-Drained Pancreas Transplantation: The Wisconsin Experience
J. Adler, R. Redfield, D. Kaufman, J. Odorico, H. Sollinger.
Surgery, University of Wisconsin School of Medicine and Public Health, Madison, WI.
INTRODUCTION: In the early experience of pancreas transplantation, bladder drainage was favored. However, this often caused metabolic and infectious complications that necessitated conversion to enteric…
2018 American Transplant Congress
Urinary C5b-9 is an Independent Predictor of Graft Failure in Renal Transplant Recipients
R. Lammerts, M. Eisenga, M. Alyami, M. Seelen, M. Daha, J. van den Born, S. Bakker, S. Berger, On behalf of the COMBAT Comsortium.
Department of Nephrology, University Medical Centre Groningen, Groningen, Netherlands.
IntroductionChronic antibody-mediated rejection is thought to be the main cause of late kidney-allograft loss, involving donor-specific antibody–mediated activation of the complement system. Activation of filtered…
2018 American Transplant Congress
Not All HLA Mismatches Are Equal: Determining the Relative De Novo DSA Induction Capacity of HLA Mismatches
V. Jucaud,¹ L. Rebellato,² K. Briley,² A. Maldonado,³ C. Haisch,² P. Bolin,² S. Kendrick,⁴ H. Jones,⁴ K. McLawhorn,⁴ D. Leeser,² M. Everly.¹
¹Terasaki Research Institute, Los Angeles, CA; ²East Carolina University, Greenville, NC; ³Vidant Medical Center, Greenville, NC; ⁴Eastern Nephrology Associates, Greenville, NC.
We studied the immunogenicity, defined as the development of de novo DSA (dnDSA), of HLA-A, -B, -DR and -DQ MM (serological) in a cohort of…
2018 American Transplant Congress
Center Variation in Six-Month Post-Donation Follow-Up of Obese Living Kidney Donors
R. Reed,¹ P. MacLennan,¹ B. Shelton,¹ M. Mustian,¹ D. McWilliams,¹ J. Blackburn,² D. Sawinski,³ J. Locke.¹
¹Surgery, University of Alabama at Birmingham, Birmingham, AL; ²Health Care Organization & Policy, University of Alabama at Birmingham, Birmingham, AL; ³Medicine, University of Pennsylvania, Philadelphia, PA.
Introduction: While post-donation follow-up in the United States has improved since implementation of minimum center compliance standards, it is still suboptimal and brief (only 2…
2018 American Transplant Congress
Long-Term Risk of Solid Organ De Novo Malignancies after Liver Transplantation: A French National Study on 11226 Patients
O. Seree, M. Altieri, J. Dumortier, GReF2.
Réseau Régional de Cancérologie Onco-Basse Normandie, Herouville St-Clair, France; Service d'Hépato-Gastroentérologie, Nutrition et Oncologie Digestive, CHU CAEN Hôpital Côte de Nacre, Caen, France; Hospices Civils de Lyon, Lyon, France.
Background and aims: De novo malignancies are one of the major late complications and cause of death after liver transplantation (LT). Using extensive data from…
2018 American Transplant Congress
In-Vivo Visualization of Regulatory B Cells Reveals Ag-Dependent T Cell Interactions That Suppress Subsequent T Cell:DC Interactions
K. Mohib, A. Cherukuri, Y. Zhou, R. David.
Starzl Transplantation Institute, Univ. of Pittsburgh, Pittsburgh, PA.
We showed that regulatory B cells (Bregs) promote long-term islet allograft survival. Using mice with a novel inducible B cell-specific deletion of IL-10 (IL-10fl/flXhCD20TAM-Cre) we…
2018 American Transplant Congress
Hospital Readmissions Following ABO-Incompatible Live Donor Kidney Transplantation: A National Study
B. Orandi,¹ X. Luo,² S. Bae,² E. King,² J. Garonzik-Wang,² D. Segev.²
¹UCSF, San Francisco; ²Hopkins, Baltimore.
30% of kidney transplant recipients are readmitted in the first month post-transplant. ABO-incompatible (ABO-I) recipients constitute a unique subpopulation that might be at higher readmission…