Am J Transplant, Volume 18, Suppl 3 Archives - Page 165 of 211 - ATC Abstracts

2018 American Transplant Congress
Pancreas and Kidney Co-Transplantation in Type II Diabetes: A Single Center Experience
J. Choi, J. Jung, H. Kwon, S. Shin, Y. Kim, D. Han.
Division of Kidney and Pancreas Transplantation, Department of Surgery, Asan Medical Center, University Ulsan College of Medicine, Seoul, Korea.
Background: Diabetic CKD patients present increased morbidity and mortality due to cardiovascular complications. Pancreas transplantation can restore insulin independence in patients with type I diabetes…
2018 American Transplant Congress
Trends in Safety Reporting to UNOS by Event Type
A. Doyle,¹ S. Tlusty,² R. Urban,² M. Marvin,³ E. Hollinger,⁵ D. Marshman,⁴ M. Green.⁵
¹Medicine, University of Virginia, Charlottesville, VA; ²UNOS, Ichmond, VA; ³Surgery, Geisinger, Davville, PA; ⁴LifeLink Foundation, Norcross, GA; ⁵Surgery, University of Pittsbugh, Pittsburgh, PA; ⁶Surgery, Rush Medical Center, Chicago, IL.
The UNOS Operations and Safety Committee is charged with reviewing reported patient safety situations, identifying safety gaps, addressing high frequency and high impact events, and…
2018 American Transplant Congress
Four Eyes Are Better Than Two: Improving Laboratory Report Quality Control
S. Dionne,² K. Klama,² H. Rashid,² A. Niedzinski.²
¹Quality Assurance, LABS, Inc., Centennial, CO; ²Infectious Disease, LABS, Inc., Philadelphia, PA.
Background: Our STAT donor-screening lab implemented a new LIMS that is used to manage patient orders, testing and reporting. We intentionally customized the LIMS to…
2018 American Transplant Congress
The Regulatory Role of Plasma Cells (as Bregs) is Counterbalanced by a NOVEL Inflammatory Role in Murine Transplant and Autoimmune Models
Z. Song,^1,2 Y. Zhou,² Q. Ding,¹ D. Rothstein.¹
¹Thomas E. Starzl Transplantation Institute, University of Pittsburgh, Pittsburgh; ²School of Medicine, Tsinghua University, Beijing, China.
Plasma Cells (PCs; B220lowCD138hiBlimp1+Ig+) in LN and spleen were shown to be the major source of B cell lineage IL-10, and absence of PCs worsens…
2018 American Transplant Congress
CD4⁺CD25^bright Regulatory T Cells Prevent Acute Xenogeneic GVHD
Y. Huang, A. Merchak, H. Xu, A. Chhabra, A. Khalil, Y. Wen, M. Binion, M. Badder, L. Kahn, S. Ildstad.
Institute for Cellular Therapeutics, University of Louisville, Louisville, KY.
Graft-versus-host disease (GVHD) is a major complication and limitation to the broad application of hematopoietic stem cell transplantation. Cell therapy has emerged as a promising…
2018 American Transplant Congress
Galangin Promotes Treg Development and Function
F. Liang,¹ H. Fang,¹ R. Zhang,¹ Q. Chen,² J. Ochando,³ Y. Ding,¹ J. Xu.¹
¹Department of Immunology, Capital Medical University, Beijing, China; ²Department of Thoracic Surgery, Chaoyang Hospital, Beijing, China; ³Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY.
Introduction: FoxP3+ Treg cells are central in controlling immune responses and transplant tolerance. CD73 (ecto-5'-nucleotidase), which serves to convert AMP to adenosine, is essential for…
2018 American Transplant Congress
Comparative Analysis of Alloantigen-Stimulated Gene Expression in HIV(+) Liver Transplant Rejectors versus Non-Rejectors
S. Chu, K. Lee, C. Ward, P. Stock, Q. Tang.
Surgery, University of California, San Francisco, San Francisco, CA.
In a multi-center, prospective trial of solid-organ transplantation in persons with HIV, recipients had a 2-3x increased rejection rate when compared to historical data on…
2018 American Transplant Congress
Subnormothermic Machine Perfusion (SNMP) with Human Hemoglobin(Hb)-Based Oxygen Carriers (HBOCs)perfusate Decreased Hepatocellular Reperfusion Injury of Donation after Cardiac Death (DCD) Donor in Pig Model
T. Shonaka,¹ N. Matsuno,¹ H. Obara,² R. Yoshikawa,² Y. Nishikawa,³ M. Gochi,¹ M. Otani,¹ H. Takahashi,¹ H. Azuma,³ H. Sakai,⁴ H. Furukawa.¹
¹Department of Surgery, Asahikawa Medical University, Asahikawa, Japan; ²Tokyo Metroporitan University, Tokyo, Japan; ³Asahikawa Medical University, Asahikawa, Japan; ⁴Nara Medical University, Nara, Japan.
Subnormothermic machine perfusion (SNMP) alleviate hepatoceller injury during organ preservation. However more oxygen is required when perfusate SNMP. Some studies demonstrated that SNMP with hemoglobin-based…
2018 American Transplant Congress
Long-Term Success of Treatment for Cardiac Transplant AMR May Depend Upon Suppressing Class II Donor Specific Antibodies
J. Hofmann,¹ D. Weisshaar,² D. Kiprov.³
¹Dept of Medicine, California Pacific Medical Center, San Francisco, CA; ²Dept of Medicine, Kaiser Permanente, Santa Clara, CA.
Antibody mediated rejection (AMR) in cardiac transplant (tspt) patients (pts) is primarily mediated by donor specific antibodies (DSAs) and associated with reduced long-term graft survival.…
2018 American Transplant Congress
Is Renal Function after Heart Transplantation an Issue for Patients with Cardiac Amyloidosis?
J. Patel, M. Kittleson, E. Kransdorf, R. Levine, S. Dimbil, D. Geft, D. Chang, L. Czer, J. Kobashigawa.
Cedars Sinai Medical Center, Los Angeles.
Purpose: Cardiac amyloidosis (CA) (AL and ATTR) is an expanding indication for transplantation. Post-transplant renal function may be affected numerous factors including pre-transplant cardiorenal syndrome,…