Am J Transplant, Volume 18, Suppl 3 Archives - Page 161 of 211 - ATC Abstracts

2018 American Transplant Congress
Human CD8⁺CD28^– Ts Cells Expanded by Common Gamma Chain (γc) Cytokines Keep Steady Allospecific Suppressive Capacity In Vivo
G. Liu,¹ F. Feng,¹ P. Zhu,¹ J. Liu,² Y. Liu,¹ Y. Yu.²
¹Department of Immunology, School of Basic Medical Science, Southern Medical University, Guangzhou, Guangdong, China; ²Department of Urology, Guangdong General Hospital, Guangdong Academy of Medical Sciences, Guangzhou, Guangdong, China.
Background: CD8+CD28- T suppressor (Ts) cells were recently reported to play a critical role in transplant tolerance, harnessing the potential for clinical use in transplantation.…
2018 American Transplant Congress
Standard Induction Immunosuppression Interferes with the Role of Vascularized Bone Marrow in Vascularized Composite Allograft Protection
N. Shockcor, E. Buckingham, W. Hassanein, A. Nam, S. Bartlett, R. Barth.
Department of Surgery, University of Maryland School of Medicine, Baltimore, MD.
Purpose: Clinical induction therapies have been demonstrated to interfere with the development of immunologic tolerance in experimental models. Vascularized bone marrow (VBM) has been demonstrated…
2018 American Transplant Congress
In Vitro α-Galactosylceramide Stimulation Expands CD4⁺CD25⁺Foxp3⁻ Regulatory T Cell Precursors in Murine Thymocytes
H. Katsumata,^1,2 M. Ikemiyagi,¹ T. Kanzawa,¹ H. Fukuda,¹ R. Ishii,¹ K. Saiga,^1,3 M. Okumi,¹ Y. Ishii,⁴ K. Tanabe.¹
¹Urology, Tokyo Women's Medical University, Tokyo, Japan; ²Division of Nephrology and Hypertension, Department of Internal Medicine, The Jikei University School of Medicine, Tokyo, Japan; ³Urology, Jyoban Hospital of Tokiwa Foundation, Fukushima, Japan; ⁴Laboratory for Immunotherapy, Center for Integrative Medical Sciences (IMS) RIKEN, Yokohama, Japan.
Background: We previously established mixed chimerism after invariant natural killer T-cell stimulation by administration of liposomal α-galactosylceramide (lipo-αGC) and costimulatory blockade, leading to regulatory T…
2018 American Transplant Congress
Application of RNA-Seq Derived Diagnostic Algorithms of T-Cell Mediated Kidney Rejection (TCMR) to DNA Microarray-Based Gene Expression Datasets
Z. Wang,¹ L. Pan,² Z. Lyu,² P. Liu,³ G. Tseng,³ P. Randhawa.¹
¹Department of Pathology, The Thomas E Starzl Transplantation Institute, University of Pittsburgh, School of Medicine, Pittsburgh, PA; ²Department of Nephrology, The First Affiliated Hospital of Guangxi Medical University, Nanning, China; ³Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA.
Recent years have seen the development of DNA microarray based tools for the diagnosis of TCMR using fresh frozen tissue. This study has accomplished the…
2018 American Transplant Congress
Assessing the Impact of Flow in Hypothermic Machine Perfusion on Human Venous Endothelium Using a Novel Ex Vivo Model
Y. Marie,¹ W. Ries,² K. Patel,¹ C. Turnbull,² N. Jamil,⁴ H. Caldwell,³ R. Telfer,² D. Neil,⁵ J. Nath,¹ N. Inston.¹
¹Department of Renal Surgery, Queen Elizabeth Hospital, Birmingham, West Midlands, United Kingdom; ²College of Medical and Dental Sciences, University of Birmingham, Birmingham, West Midlands, United Kingdom; ³Division of Pathology Laboratories, Western General Hospital, Edinburgh, United Kingdom; ⁴Department of Cellular Pathology, Durham and Darlington NHS Foundation Trust, Newcastle, Newcastle Upon Tyne, United Kingdom; ⁵Department of Histopathology, University Hospitals Birmingham NHS Trust, Birmingham, West Midlands, United Kingdom.
BACKGROUNDHypothermic machine perfusion (HMP) involves dynamic flow of chilled preservation fluid through an allograft's vasculature. This study describes a simple, reproducible, human model that allows…
2018 American Transplant Congress
The Combination of pAMR and Circulating Donor-Specific Antibodies is Even More Associated with Cardiac Allograft Vasculopathy after Heart Transplant
J. Patel, M. Kittleson, E. Kransdorf, S. Dimbil, R. Levine, D. Geft, D. Chang, L. Czer, J. Kobashigawa.
Cedars Sinai Medical Center, Los Angeles.
Purpose: Several reports have correlated the development of donor-specific antibody (DSA) to the development of cardiac allograft vasculopathy (CAV) after heart transplantation (HTx). Interestingly, patients…
2018 American Transplant Congress
Air Pollution Can Support the Development of Cardiac Allograft Vasculopathy
C. Bara,¹ M. Barten,² D. Boethig,¹ Y. Scheibner,¹ J. Tauber,² H. Reichenspurner,² A. Haverich.¹
¹Cardiothoracic, Transplantation and Vascular Surgery, Hannover Medical School, Hannover, Germany; ²Cardiovascular Surgery, University Heart Center, Hamburg, Germany.
Purpose:Cardiac allograft vasculopathy (CAV) remains one of most important factors leading to graft dysfunction and mortality after heart transplantation (HTx). Thus, the identification of risk…
2018 American Transplant Congress
Decreased Post Heart Transplant Survival with Epstein-Barr Virus Mismatch in the Current Era
M. Kittleson, J. Patel, E. Kransdorf, S. Dimbil, R. Levine, S. Mersola, D. Geft, D. Chang, L. Czer, J. Kobashigawa.
Cedars Sinai Medical Center, Los Angeles.
Purpose: Epstein-Barr virus (EBV) has been implicated in a multitude of cancers, including B-cell lymphoma, Burkitt's lymphoma, CNS lymphoma, gastric cancer and nasopharyngeal carcinoma. Previous…
2018 American Transplant Congress
Quantification of the Indirect Effect of Recipient Characteristics on Kidney Graft Function
S. Rao,¹ A. Gillespie,¹ J. Lee,¹ K. Lau,² S. Karhadkar,² A. Di Carlo,² S. Constantinescu.¹
¹Medicine, Lewis Katz School of Medicine, Temple University, Philadelphia, PA; ²Surgery, Lewis Katz School of Medicine, Temple University, Philadelphia, PA.
Recipient characteristics play an important role for donor selection in deceased donor kidney transplant recipients (DDKT). The current kidney allocation system (KAS) for deceased donors…
2018 American Transplant Congress
Two Decades of Eurotransplant Senior Program (ESP): Time on Dialysis Independently Impacts Patient Survival, Allograft Survival and Quality of Life after Kidney Transplantation
T. Schachtner,^1,2,3 N. Otto,¹ P. Reinke.^1,2
¹Nephrology and Internal Intensive Care, Charite Campus Virchow Clinic, Berlin, Germany; ²Berlin-Brandenburg Center for Regenerative Therapies (BCRT), Charite Campus Virchow Clinic, Berlin, Germany; ³Berlin Institute of Health (BIH), Charite and Max Delbrueck Center, Berlin, Germany.
In 1999, the Eurotransplant Senior Program (ESP) was implemented and allocates kidneys from deceased-donors ≥65 years to kidney transplant recipients ≥65 years (ESP-KTRs). The ESP…