Am J Transplant, Volume 18, Suppl 3 Archives - Page 161 of 211 - ATC Abstracts

2018 American Transplant Congress
Analysis of Circulating CD38+/CD138+ Plasma Cells during Development of De Novo Donor Specific Antibody Responses
N-.N. Chai, G. Wu, I. Kim, S. Jordan, A. Klein.
CTC/Surgery, Cedars-Sinai Medical Center, Los Angeles, CA.
Purpose: Donor specific antibodies (DSA) that emerge following transplantation are indicative of allogenic sensitization and a predisposing factor for antibody mediated rejection. Though various methods…
2018 American Transplant Congress
Assessing Necroptosis in Brain Dead Kidney Donors: Implications for Predicting Recipient Outcomes
A. Zmijewska, J. Murphy, J. Chen, J. Zmijewski, R. Mannon.
Medicine, University of Alabama at Birmingham, Birmingham, AL.
Introduction: Kidney graft transplant obtained from Brain Dead Donors (BDD) is more frequently associated with development of delayed graft function (DGF) and higher risk of…
2018 American Transplant Congress
Targeting Calcium Release-Activated Calcium (CRAC) Channel in Non-Human Primate Kidney Transplantation
J. Kwun,¹ B. Ezekian,¹ M. Manook,¹ J. Park,¹ J. Yoon,¹ J. Sloan-Lancaster,² C. Fortier,³ P. Rao,⁴ S. Knechtle.¹
¹Surgery, Duke University, Durham, NC; ²Eli Lilly and Company, Indianapolis, IN, Canada; ³PRCL Research Inc, Montreal, QC, Canada; ⁴Synta Pharmaceuticals Inc., Lexington, MA.
[Background] Long-term administration of calcineurin inhibitors (CNIs) successfully controls rejection of transplanted organs. However, the chronic use of these drugs causes organ damage often resulting…
2018 American Transplant Congress
Preoperative Antibiotics Treatment Decreases Endoplasmic Reticulum Stress and Protects Liver Transplant from Ischemia-Reperfusion Injury
T. Ito, F. Kaldas, K. Nakamura, S. Kageyama, A. Aziz, R. Busuttil, J. Kupiec-Weglinski.
Department of Surgery, The Dumont-UCLA Transplant Center, Los Angeles, CA.
Ischemia-reperfusion injury (IRI) represents a major risk factor of graft dysfunction in liver transplantation (LT). We have reported a critical role of endoplasmic reticulum (ER)…
2018 American Transplant Congress
Donor Specific Antibodies Increase the Risk of Preeclampsia in Pregnant Kidney Transplant Recipients
M. Lubetzky, T. Muthukumar, J. Lee, J. Lee, C. Hartono, L. Mahla, D. Serur, D. Dadhania.
Weill Cornell-New York Presbyterian, NY, NY.
Kidney transplant recipients are at an increased risk for pregnancy-associated complications including preeclampsia (PEC). Endothelial injury in the placenta is a hallmark of PEC. The…
2018 American Transplant Congress
Metabolic Acidosis after Kidney Transplantation: Prevalence, Risk Factors and Graft Outcome in a French Cohort
F. Garo, I. Szwarc, G. Mourad, M. Le Quintrec, J-.E. Serre.
Nephrology, University Hospital of Montpellier, Montpellier, France.
Background: Metabolic acidosis (MA) lead to several complications in more advanced stages of chronic kidney diseases (CKD) and promotes CKD progression. Acidosis is a common…
2018 American Transplant Congress
Outcome Analysis of Renal Re-Transplantation Compared to a Matched Control Group of First Transplantation
A. Schwarz,¹ F. Schaefer,¹ T. Framke,² S. Linnenweber,¹ H. Haller.¹
¹Nephrology, Hannover Medical School, Hannover, Germany; ²Biostatistics, Hannover Medical School, Hannover, Germany.
Background: 15% of our renal transplant program is re-transplantation (Tx2). We aimed to know if Tx2 has a higher risk than first transplantation (Tx1) and…
2018 American Transplant Congress
Pump Resistive Index Values and Not Preimplantation Kidney Biopsy Predict Kidney Allograft Survival
J. Liu,¹ A. Blumfield,¹ M. Trivedi,¹ N. Mishra,¹ O. Mohammed,^1,2 J. Lin,³ M. Ajaimy,^1,2 J. Graham,^1,2 J. Rocca,^1,2 E. Akalin,^1,2 S. Greenstein.^1,2
¹Albert Einstein College of Medicine, Bronx, NY; ²Department of Surgery, Montefiore Medical Center, Bronx, NY; ³Department of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, NY.
AimTo investigate the relationship between histological findings of preimplantation kidney biopsies and pump resistive index (RI) values during machine preservation and subsequent allograft survival.MethodsWe retrospectively…
2018 American Transplant Congress
Elevated Donor Terminal Creatinine Does Not Appear to Be Associated with Worse Outcomes in Kidney Transplantation
S. Rayhill, J. Haldorson.
U Washington, Seattly.
There is justified reluctance to use kidneys from donors with significantly elevated creatinine as they may have severe, irreversible injury. Recently, thanks, in part to…
2018 American Transplant Congress
Safety and Efficacy of Sofosbuvir-Based Direct-Acting Antiviral Agents in Kidney Transplant Recipients with HCV: A Systematic Review and Meta-Analysis
X. Wang,¹ P. Tan,¹ T. Xiang,² Y. Qiu,¹ T. Song,¹ T. Lin.¹
¹Department of Urology/Institute of Urology/Organ Transplantation Center, West China Hospital, Sichuan University, Chengdu, Sichuan Province, China; ²West China School of Clinical Medicine, Sichuan University, Chengdu, Sichuan Province, China.
Background: Outcome data on sofosbuvir (SOF)-based therapy in patients with kidney transplantation (KTx) with hepatitis C virus infection are limited with individual studies having a…