2018 American Transplant Congress
The ATHENA Study: 12 Months Safety and Efficacy Data from Everolimus Combined with Tacrolimus or Cyclosporine Compared to a Standard Tacrolimus-Mycophenolate Regimen in De Novo Kidney Transplant Patients
1Athena Study Group, Germany; 2Athena Study Group, France; 3Novartis, Pharma, Germany.
The ATHENA study was set up to compare efficacy and safety of everolimus [EVR] combined with tacrolimus [TAC] or cyclosporine A [CyA] vs. a mycophenolic…2018 American Transplant Congress
Factors Related to Suboptimal Recovery of Renal Function after Living Donor Nephrectomy
Japanease Red Cross Kumamoto Hospital, Kidney Center, Kumamoto, Japan.
Introduction:Renal function of the living donor usually recovers to 60~70 percent of baseline function by compensatory hypertrophy mechanism. However, the degree of this compensatory hypertrophy…2018 American Transplant Congress
Opiate Use Trends after Liver Transplantation and the Factors Associated with Post-Transplant Opiate Dependence
1Henry Ford Hospital, Detroit, MI; 2Wayne State University SOM, Detroit, MI.
AimsOur study aims to determine predictive factors leading to post-liver transplant (LT) opioid dependence.MethodsA retrospective chart review was conducted including LT recipients from July 2013-June…2018 American Transplant Congress
CD8+ Tissue Resident Memory T Cells Are Key Effector Cells in Intestinal Transplantation Patients with GvHD
Medstar Georgetown Transplant Institute, Medstar Georgetown University Hospital, Washington, DC.
A. As the pathophysiologic role of Tissue Resident Memory T Cells (TRM) in intestinal transplantation (ITx) is unknown, this study aims to test the hypothesis…2018 American Transplant Congress
VLA-4 Blockade Inhibits Early Endogenous Memory CD8 T Cell Infiltration into Higher Risk Cardiac Allografts and Donor-Reactive T Cell Priming
Endogenous memory CD8 T cells infiltrate MHC-mismatched cardiac allografts within 24 hrs after graft reperfusion in mice. Our recent studies indicate that prolonged cold ischemic…2018 American Transplant Congress
Immunophenotype of Cells Infiltrating the Graft Explains the Benefits of Belatacept
Previously, we found greater amounts of FoxP3 cells and lower amounts of CD4+/IL-17A+ and senescent cells in belatacept (Bela) patients compared to patients under cyclosporine…2018 American Transplant Congress
Clinical Outcomes of Patients with BK Viremia in ABO-Incompatible Kidney Transplantation and Comparison with ABO-Compatible Kidney Transplantation
Internal Medicine, Asan Medical Center, Seoul, Republic of Korea.
Background and Aim:ABO-incompatible kidney transplantation (ABOiKT) recipients may have an increased risk of BK virus allograft nephropathy (BKVAN), a major cause of renal dysfunction and…2018 American Transplant Congress
Influence of Liver Allograft Steatosis on Postoperative Acute Kidney Injury
1Mayo Clinic, Phoenix, AZ; 2Mayo Clinic, Rochester, MN.
With the ongoing organ shortage, there has been an increased interest in using moderately steatotic liver allografts. The impact of such allografts on recipients' post-liver…2018 American Transplant Congress
Alveolar Macrophages Derived from MCMV Latently Infected Donors Drives the Viral Reactivation and Dissemination Following the Orthotopic Left Lung Transplantation in Mice
Background: The incidence of cytomegalovirus (CMV) disease is higher in lung transplants, than in other SOT recipients, especially in high-risk D+/R- recipients. Using a murine…2018 American Transplant Congress
Mitochondrial Autophagy Proteins Bnip3 and Nix Maintain Memory B Cell Survival
Despite the use of immunosuppressive drugs, allograft rejection remains a major hurdle for the long-term success of organ transplants. Burgeoning evidence implicates memory B cells…
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