Am J Transplant, Volume 18, Suppl 3 Archives - Page 156 of 211 - ATC Abstracts

2018 American Transplant Congress
Successful Desensitization with Carfilzomib-Based Regimen to Facilitate Lung Transplantation: Initial Experience
C. Ensor,¹ A. Zeevi,¹ M. Mangiola,¹ C. Iasella,¹ M. Marrari,¹ M. Morrell,¹ E. Lendermon,¹ S. Kilaru,¹ N. Shigemura,² J. DCunha,¹ J. McDyer.¹
¹University of Pittsburgh, Pittsburgh, PA; ²Temple University, Philadelphia, PA.
Purpose:We describe the successful desensitization of highly sensitized lung transplant candidates (LTCs) using plasma exchange (PLEX),intravenous immunoglobulin G(IVIg),and carfilzomib.Methods:5-patient case series of successful desensitization of…
2018 American Transplant Congress
Preventing of Rejection of Vascularized Composite Allografts by Targeting T Cell Metabolism
B. Oh,¹ C. Cheng,² G. Furtmüller,¹ K. Donovan,¹ W. Lee,¹ J. Powell,² G. Brandacher.¹
¹Plastic and Reconstructive Surgery, Johns Hopkins SOM, Baltimore; ²Oncology, Johns Hopkins SOM, Baltimore.
[Background] Upon antigen recognition and co-stimulation, T lymphocytes upregulate the metabolic machinery necessary to proliferate and sustain effector function. This metabolic reprogramming in T cells…
2018 American Transplant Congress
Evaluation of the Use of Oral Valganciclovir for the Treatment of Cytomegalovirus Infections in Pediatric Intestinal Transplant Recipients: A Single Center Review
M. Henry, M. Vacha, M. Keck, D. Florescu.
Nebraska Medicine, Omaha, NE.
Purpose: To evaluate the safety and efficacy of oral valganciclovir in treating cytomegalovirus (CMV) infections in pediatric intestinal transplant recipients (pITR).Methods: This retrospective review included…
2018 American Transplant Congress
Impact of Influenza Vaccine Implementation by Transplant Pharmacy in Solid Organ Transplant Recipients
S. Gattis,¹ I. Yildirim,^1,2 S. Serluco,¹ C. McCracken,² R. Liverman.¹
¹Children's Healthcare of Atlanta, Atlanta, GA; ²Emory University School of Medicine, Atlanta, GA.
Background: In solid organ transplant (SOT) recipients, influenza infection can lead to subsequent graft dysfunction and mortality. In an effort to increase vaccination rates, transplant…
2018 American Transplant Congress
Bacterial Complications in Liver Transplant Recipients Undergoing Biliary Tract Manipulation: Effect of an Antibiotic Prophylaxis Protocol
C. Clifford, N. Theodoropoulos, J. Daly, L. Gibson, S. Mehta, H. Malik, A. Bozorgzadeh.
University of Massachusetts Medical School, Worcester, MA.
Purpose: The purpose of this study was to evaluate incidence of bacteremia and outcomes in liver transplant recipients that had biliary tract manipulation before and…
2018 American Transplant Congress
In Vivo Administration of Plerixafor and Bortezomib Results in Bone Marrow Plasma Cell Mobilization and Death While Inducing Biphasic Plasma Cell Apoptosis in Peripheral Blood
E. Woodle,¹ S. Tremblay,¹ C. Castro-Rojas,² S. Knechtle,³ A. Shields,¹ R. Alloway,¹ H. Singh,² J. Driscoll,¹ D. Hildeman.²
¹U Cincinnati, Cincinnati; ²Cincinnati Children's, Cincinnati; ³Duke, Durham.
Bone marrow (BM) plasma cells (PC) secreting HLA antibody (Ab) remain a persistent reservoir of donor specific Ab and present a significant hurdle to allograft…
2018 American Transplant Congress
Potential Impact of DCD Donor Recoveries on Heart Transplantation: Retrospective Analysis of a Limited UNOS Dataset
J. Lindower,² M. Farr,¹ S. Taylor,² U. Jorde,³ L. Chen,⁴ A. Gass,⁵ L. Truby,¹ S. Delair,² S. Pinney.⁶
¹New York Cardio-Thoracic Transplant Consortium, Troy, NY; ²Columbia/New York Presbyterian Hospital, New York; ³Montefiore Medical Center, Bronx, NY; ⁴Rochester University Medical Center, Rochester, NY; ⁵Westchester Medical Center, Valhalla, NY; ⁶Mount Sinai Medical Center, New York, NY.
Purpose: To review the volume and quality of potential DCD (Donation after Cardiac Death) Heart Transplant (HT) donors in the US, evaluate trends over time…
2018 American Transplant Congress
Evaluation of Drug Action on IgM Memory B Cell Survival and Growth In Vitro; -Application for Individualized Immunosuppression after Kidney Transplants-
Y. Matsuda,¹ K. Takahashi,¹ R. Imamura,² N. Nonomura,² Y. Yuzawa.¹
¹Nephrology, Fujita Health University, Toyoake, Aichi, Japan; ²Urology, Osaka University, Suita, Osaka, Japan.
(Background)Recently, the establishment of early diagnosis and treatment methods for antibody-mediated rejection (ABMR) has garnered much attention.Strong immunosuppression including desensitization is accompanied by severe side…
2018 American Transplant Congress
Factors Predicting Viability Achievement on Discarded Donor Livers Submitted to Extra-Corporeal Machine Perfusion
Y. Boteon,^1,2 R. Laing,^1,2 A. Schlegel,² J. Attard,^1,2 L. Wallace,¹ A. Smith,² T. Perera,² J. Isaac,² D. Mirza,² S. Afford,¹ H. Mergental.²
¹National Institute for Health Research, Birmingham Liver Biomedical Research Centre, University of Birmingham, Institute of Immunology and Immunotherapy, Birmingham, United Kingdom; ²Liver Unit, Queen Elizabeth Hospital, University Hospitals Birmingham, Birmingham, United Kingdom.
Background: Ex-vivo machine perfusion of livers (MP) may offer superior preservation for marginal donor organs. During normothermic machine perfusion (NMP) is possible to assess liver…
2018 American Transplant Congress
Comparison of Outcomes in African-American and White Primary Kidney Transplant Recipients: A Matched-Pair Analysis
F. Tedla, A. Brar, D. John, N. Sumrani, R. Gruessner, A. Gruessner, M. Salifu.
SUNY Downstate Medical Center, Brooklyn, NY.
Background: Racial differences in clinical and sociodemographic characteristics have been well recognized. This study aims to assess outcomes in African-American (AA) and white primary deceased…