Am J Transplant, Volume 18, Suppl 3 Archives - Page 153 of 211 - ATC Abstracts

2018 American Transplant Congress
Liver Stiffness Measurement, but Not Controlled Attenuation Parameter, is Increased in Deceased Liver Donors at the Time of Transplant Procurement
A. Duarte-Rojo,¹ G. Barone,¹ D. Borja-Cacho,¹ W. Concepcion,² M. Shaheen,³ J. Heimbach,³ W. Kim.²
¹University of Arkansas for Medical Sciences, Little Rock, AR; ²Stanford University, Palo Alto, CA; ³Mayo Clinic, Rochester, MN.
Background & Aims: The growing obesity rate and IV drug use in the USA presage a higher usage of liver allografts with NAFLD or active…
2018 American Transplant Congress
Clinical Impact of Denovo or Recurrent Donor Specific Antibodies in the First Year Post Kidney Transplant in Patients on Early Steroid Withdrawal Immunosupression Regimen
O. Adebiyi, T. Taber, W. Goggins, D. Mishler, M. Yaqub, A. Sharfuddin.
Division of Renal Disease and Hypertension, Indiana University Health, Indianapolis, IN.
Background: Immunologic risk monitoring of recipients of kidney transplant(Tx) using donor specific antibodies (DSA) has become a standard practice in most Tx centers in the…
2018 American Transplant Congress
400 Kidney Paired Donor Transplants at a Single Center; The Methodist San Antonio Experience
A. Bingaman,¹ M. Kapturczak,¹ I. Ashlagi,² C. Murphey.³
¹Methodist Specialty and Transplant Hospital, San Antonio, TX; ²Stanford University, Palo Alto, CA; ³Southwest Immunodiagnostics, San Antonio, TX.
Background: Kidney paired donation (KPD) has become the standard of care for incompatible living donor pairs. Several mature national KPD programs exist yet KPD transplants…
2018 American Transplant Congress
Origin and Pattern of Human Polyomaviruses Replication after Kidney Transplantation: A Prospective Study
E. Favi,¹ S. Delbue,² C. Colico,¹ P. Ferrante,² S. Villani,² I. Perna,² N. Mondoni,² A. Giussani,¹ L. Clementoni,¹ P. Messa,³ M. Ferraresso.¹
¹Kidney Transplantation, Fondazione IRCCS Ca' Granda, Milan, Italy; ²Biomedical, Surgical and Dental Sciences, University of Milan, Milan, Italy; ³Nephrology, Fondazione IRCCS Ca' Granda, Milan, Italy.
Background. Human Polyomaviruses (HPyVs) are able to establish latent infection in the kidney of the host. Immunosuppression is recognized risk factor for HPyVs reactivation. Besides…
2018 American Transplant Congress
Morphometric and Metabolic Correlates of Frailty in Pancreas Transplant Recipients
R. Parsons, J. Wolosyn, R. Lynch.
Surgery, Emory University, Atlanta, GA.
Background: Prediction of survival and health resource utilization in the pancreas transplant population requires novel approaches to risk stratification. We studied whether sarcopenia and osteopenia,…
2018 American Transplant Congress
A Novel Peripheral Blood mRNA Biomarker Predicts Subclinical Rejection and Kidney Transplant Outcomes
J. Friedewald,¹ S. Kurian,² T. Whisenant,² R. Heilman,³ E. Poggio,⁴ C. Marsh,² P. Baliga,⁵ N. Bridges,⁶ J. Odim,⁶ M. Brown,⁶ D. Ikle,⁷ B. Armstrong,⁷ J. Charette,¹ S. Brietigam,¹ N. Sustento-Reodica,¹ L. Zhao,¹ M. Kandpal,¹ D. Salomon,² M. Abecassis.¹
¹Northwestern Medicine, Chicago; ²Scripps, La Jolla; ³Mayo AZ, Scottsdale; ⁴Cleveland Clinic, Cleveland; ⁵MUSC, Charleston; ⁶NIAID, Bethesda; ⁷Rho, Chapel Hill.
BACKGROUNDSub-clinical acute rejection (subAR) in kidney transplant recipients (KTR), defined as histological rejection on surveillance biopsy (Bx) in a patient with stable renal function, signals…
2018 American Transplant Congress
Two Trajectories of Post-DSA eGFR after Kidney Transplant
J. Beaumont,¹ K. Briley,² A. Maldonado,³ C. Haisch,² P. Bolin,² S. Kendrick,⁴ H. Jones,⁴ K. McLawhorn,⁴ D. Leeser,² L. Rebellato,² M. Everly.¹
¹Terasaki Research Institute, Los Angeles, CA; ²East Carolina University, Greenville, NC; ³Vidant Medical Center, Greenville, NC; ⁴Eastern Nephrology Associates, Greenville, NC.
A clearer understanding of the patterns of glomerular filtration rate (GFR) decline following donor-specific antibody (DSA) development and the factors that might be associated with…
2018 American Transplant Congress
Meeting OPTN Requirements for Living Kidney Donation Follow-Up: Findings from the KDOC Study
J. Rodrigue,¹ C. Sokas,¹ A. Fleishman,¹ J. Schold,² P. Morrissey,³ J. Whiting,⁴ J. Vella,⁴ L. Kayler,⁵ D. Katz,⁶ J. Jones,⁶ B. Kaplan,⁷ M. Pavlakis,¹ D. Mandelbrot.⁸
¹Beth Israel Deaconess Medical Center, Boston; ²Cleveland Clinic, Cleveland; ³Rhode Island Hospital, Providence; ⁴Maine Medical Center, Portland; ⁵Erie County Medical Center, Buffalo; ⁶University of Iowa, Iowa City; ⁷Mayo Clinic, Scottsdale; ⁸University of Wisconsin, Madison.
The Organ Procurement and Transplantation Network (OPTN) requires programs to submit complete, accurate and timely clinical information for 80% and laboratory data for 70% of…
2018 American Transplant Congress
Influence of Initial Tumor Burden and Wait Times on Post-Transplant Outcomes after Down-Staging of Hepatocellular Carcinoma (HCC)
N. Mehta, J. Dodge, F. Yao.
UCSF, San Francisco.
Background: A new national policy has adopted the UNOS Region 5 down-staging protocol for liver transplant (LT) in HCC meeting the following inclusion criteria -…
2018 American Transplant Congress
OX40 Costimulation Prevents Induction of Foxp3⁺ Tregs through Upregulation of Novel Repressors of Foxp3 Gene Expression
X. Zhang,¹ X. Xiao,¹ P. Lan,¹ J. Li,¹ Y. Dou,¹ W. Chen,¹ N. Ishii,² S. Chen,¹ E. Taparowsky,³ X. Li.^1,4
¹Immunobiology & Transplant Research Center, Houston Methodist Hospital, Houston, TX; ²Department of Microbiology and Immunology, Tohoku University, Sendai, Japan; ³Department of Biological Sciences, Perdue University, Lafayette, IN; ⁴Department of Surgery, Weill Cornell Medical College of Cornell University, New York, NY.
Foxp3+ Tregs are essential for the induction of transplant tolerance and OX40 costimulation is known to break transplant tolerance. The exact mechanism of OX40 in…