Am J Transplant, Volume 18, Suppl 3 Archives - Page 152 of 211 - ATC Abstracts

2018 American Transplant Congress
Improving Organ Donation Rates through a Primary Care Physician Office-Based Intervention
R. Kashyap,¹ M. Dokus,¹ N. Ryan,³ A. James,³ R. Kochik,³ R. Hernandez,¹ J. Dolan,² P. Veazie,² M. Orloff,¹ S. McIntosh.²
¹Surgery, Transplant, University of Rochester Medical Center, Rochester, NY; ²Public Health Sciences, URMC, Rochester, NY; ³Finger Lake Donor Recovery Network, URMC, Rochester, NY.
Background: The inadequate supply of suitable deceased donor organs is well documented. Studies have suggested that Primary Care Providers (PCPs) could help improve donor registration…
2018 American Transplant Congress
Preoperative Patient Education to Improve the Inpatient Experience for Living Donors
K. Ventura, K. Sigafus.
Transplant Department, Hospital of the University of Pennsylvania, Philadelphia, PA.
Purpose: Although the number of living organ donors is small, their altruistic sacrifice requires a dedicated approach to meet their unique needs. Living donors (LD)…
2018 American Transplant Congress
Achieving Allograft Tolerance through Antigen-Specific Regulatory B Cells
C. Rickert,^1,2 S. Kimura,^1,2 L. Kojima,¹ K. Lee,¹ M. Aburawi,¹ F. Fontan,¹ K. Deng,¹ H. Yeh,^1,2 J. Markmann.^1,2
¹Center for Transplantation Sciences, Massachusetts General Hospital, Boston, MA; ²Transplantation Unit, Department of Surgery, Massachusetts General Hospital, Boston, MA.
IntroductionA complete understanding of the role of antigen-specificity in the development of B cell mediated allograft tolerance has remained elusive. Previous work in our lab…
2018 American Transplant Congress
Heart En Bloc Thymus Cotransplantation in NHPs Controls Cellular but Not Humoral Alloreactivity
W. Sommer, J. O., K. Pruner, J. Paster, M. Hanekamp, A. Dehnadi, I. Rosales, R. Smith, R. Colvin, G. Benichou, J. Allan, J. Madsen.
Massachusetts General Hospital, Boston.
Background: We have achieved tolerance of cardiac allografts in Cynomolgus monkeys for the first time by using a mixed chimerism-based conditioning protocol and by co-transplanting…
2018 American Transplant Congress
Hsp70 Inhibitor Could Induce Transplant Tolerance through mTORC2/Akt Pathway
G. Gu, T. Lu, N. Xu, Q. Xia.
Department of Liver Surgery, Renji Hospital, Affiliated by Shanghai Jiaotong University School of Medicine, Shanghai, China.
Hsp70, a highly conserved protein, has been shown to induce strong immune responses and to reduce inflammation. However, its mechanism is not clear, especially in…
2018 American Transplant Congress
Intensified Immunosuppression Improves Early Renal Allograft Function after Transplantation in a Porcine Model with Extended Asystolic Warm Ischemic Time
M. Xu,¹ X. Wang,¹ S. Garcia-Aroz,¹ B. Banan,¹ B. Rabe,¹ Z. Zhang,¹ J. Jia,¹ G. Upadhya,¹ P. Manning,² J. Gaut,³ Y. Lin,¹ W. Chapman.¹
¹Department of Surgery, Section of Abdominal Transplantation, Washington University School of Medicine, St. Louis, MO; ²Arch Oncology, St. Louis, MO; ³Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO.
PURPOSE: Extensive ischemia-reperfusion injury significantly increases the immunogenicity of renal allograft which may be associated with increased risk of acute rejection (AR). This study investigated…
2018 American Transplant Congress
Targeting LTβR Classical NFκB Signaling Facilitates Inflammation Resolution
W. Piao, Y. Xiong, L. Li, V. Saxena, J. Bromberg.
UMB, Baltimore.
Background:Contact hypersensitivity (CHS) is a reliable model to assess the immune cell-mediated cutaneous inflammatory response, which includes the three phases of priming/sensitization, elicitation, and resolution,…
2018 American Transplant Congress
Impact of Pre-Transplant Non-Dialysis Renal Dysfunction in Heart Transplant Recipients on Post-Transplant ESRD: A UNOS Database Analysis
S. Akkina, A. Desai, J. Yoo, S. Hou, R. Parasuraman.
Medicine, Loyola University Medical Center, Maywood, IL.
Dialysis prior to heart transplant (HTx) is a strong predictor of patient death and is a common indication for simultaneous heart/kidney transplantation (SHK). The association…
2018 American Transplant Congress
Safety and Efficacy of Rabbit Anti-Thymocyte Globulin Induction in Pediatric Patients Undergoing Cardiac Transplantation
M. Sell,¹ A. Haney,¹ K. Sprott,¹ A. Burnette,² H. Henderson,² A. Savage.²
¹Pharmacy, Medical University of South Carolina, Charleston, SC; ²Cardiac Transplant, Medical University of South Carolina, Charleston, SC.
Purpose: Limited data are available in pediatric cardiac transplant patients that focus on the safety and efficacy of rabbit anti-thymocyte globulin (rATG) induction therapy. The…
2018 American Transplant Congress
Outcomes after Cardiac Transplantation for Adult Congenital Heart Disease in the Modern Era
X. Zeng,¹ R. Vela,² J. Pruszynski,² J. Martinez,² S. Ring,² M. Peltz.²
¹Surgery, University of Texas Southwestern Medical Center, Dallas, TX; ²Cardiovascular and Thoracic Surgery, University of Texas Southwestern Medical Center, Dallss, TX.
Background: More patients with congenital heart disease (CHD) are surviving into adulthood and require heart transplantation. These patients historically experienced worse survival early after transplantation.…